Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine

Kavala, Mukaddes; Sudogan, Sibel; Zindancı, İlkin; Kocatürk, Emek; Can, Burçe; Türkoğlu, Zafer; Altintas, Sumeyye

doi:10.1111/j.1365-4632.2010.04149.x

Cited by 28 publications

(16 citation statements)

References 18 publications

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“…Microangiopathy, immune complex vasculitis with involvement of T cells, release of proinflammatory cytokines, and abnormal collagen production have all been implicated [11]. Several different therapies have been reported with limited success in the literature, including topical and systemic corticosteroids, nicotinamide, pentoxifylline, tretinoin, anti-TNF- α , mycophenolate mofetil, thalidomide, cyclosporine, tacrolimus, dipyridamole-aspirin, antimalarials, and PUVA [12–14]. …”

Section: Discussionmentioning

confidence: 99%

Remission of Ulcerated Necrobiosis Lipoidica Diabeticorum after Bariatric Surgery

Bozkurt

Coşkun

Kadıoğlu

et al. 2013

Case Reports in Dermatological Medicine

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A 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.

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Section: Discussionmentioning

confidence: 99%

Remission of Ulcerated Necrobiosis Lipoidica Diabeticorum after Bariatric Surgery

Bozkurt

Coşkun

Kadıoğlu

et al. 2013

Case Reports in Dermatological Medicine

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“…According to some reports, smoking cessation and blood glucose control is recommended [1, 2]. Other therapeutic options are antiplatelet agents [3], cyclosporine [1, 2, 3, 8], thalidomide [3, 8], clofazimine [2], anti-TNF agents [3, 8], fumaric acid esters [2, 8], PUVA [2, 3, 8], photodynamic therapy [8, 9], hydroxychloroquine [10] and tacrolimus [3, 11, 12, 13]. …”

Section: Discussionmentioning

confidence: 99%

Necrobiosis Lipoidica: Early Diagnosis and Treatment with Tacrolimus

Patsatsi¹,

Kyriakou²,

Sotiriadis³

2011

Case Rep Dermatol

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We present a case of necrobiosis lipoidica (NL) with atypical early lesions and good response to topical tacrolimus. NL is a disease with clinical features that are seldom misinterpreted. Often histology just confirms the clinician’s diagnosis. Only in rare cases, the clinical presentation and the involved body sites may be misleading. A 67-year-old diabetic woman was admitted to our department with a well-defined, persistent plaque on her left arm and on her right shin. Histologic examination of both lesions revealed features of NL despite the dissimilar clinical presentation. The patient was treated with 0.1% topical tacrolimus ointment twice daily for 8 weeks and once daily for 8 weeks. A significant improvement and no further lesions were observed after 1 year of follow-up. A high index of suspicion regarding NL lesions with atypical clinical presentation on different body sites is advised in order to avoid misdiagnosis, wrong treatment decisions and ulceration. Additionally, it appears that topical tacrolimus treatment is an effective therapeutic option in patients with recent, non-ulcerated NL lesions.

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“…These mechanisms may explain the response of NL to hydroxychloroquine and chloroquine. 77,78 Effects take 1 to 3 months to be fully realized, and long-term data are still lacking. The risk of irreversible retinopathy is rare with courses of less than 5 years, but visual haloes occur more commonly because of rapid deposition of medication in the cornea.…”

Section: Antimalarialmentioning

confidence: 99%

Necrobiosis Lipoidica

Sibbald¹,

Reid²,

Alavi³

2015

Dermatologic Clinics

110

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Necrobiosis lipoidica is a granulomatous condition presenting as indolent atrophic plaques, often on the lower extremities. There is a multitude of case reports suggesting possible associations and documenting different therapeutic alternatives with varied success. Important complications include ulceration and the development of squamous cell carcinoma. The disease course is often indolent and recurrent despite treatment. This article reviews the etiopathogenesis, clinical presentations, and evidence for treatment alternatives of this condition.

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Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine

Cited by 28 publications

References 18 publications

Remission of Ulcerated Necrobiosis Lipoidica Diabeticorum after Bariatric Surgery

Remission of Ulcerated Necrobiosis Lipoidica Diabeticorum after Bariatric Surgery

Necrobiosis Lipoidica: Early Diagnosis and Treatment with Tacrolimus

Necrobiosis Lipoidica

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