Significant Increase in the Incidence of Ventricular Arrhythmic Events After an Intrathoracic Impedance Change Measured With a Cardiac Resynchronization Therapy Defibrillator

Evaluation of Volume Depletion in Patients With Heart Failure Using Intrathoracic Impedance Monitoring

“…Another recent study in the Journal demonstrated that impedance monitoring may predict arrhythmic events, including life-threatening ventricular arrhythmias, in HF patients. 12 We look forward to the authors' future prospective study validating their results discussed here, which will expand the utility of non-invasive monitoring using implantable devices to deliver better patient care.…”

Trying to predict the unpredictable: Variations in device-based daily monitored diagnostic parameters can predict malignant arrhythmic events in patients undergoing cardiac resynchronization therapy

“…Gradually faster HRs together with progressively declining TI prior to arrhythmia suggest the second mechanism involved in arrhythmogenesis -hemodynamic decompensation [25]. Although in studied group only 6% of arrhythmias showed temporal relationship to HF exacerbation, subclinical decompensation with volume overload and compensatory elevated HR is a very likely mechanism of arrhythmogenesis [20][21][22]. A progressively decreasing TI with initial plateau and subsequent fast decline prior to arrhythmia is difficult to explain from physiological point of view.…”

“…All available analyses concentrated on a single parameter -TI and indicated, that its decline heralds upcoming arrhythmic event [20][21][22]. Our observations on daily variations in biologic parameters preceding arrhythmia can be explained by several mechanisms, two of which seem to be the most reasonable: transiently elevated sympathetic drive and subclinical hemodynamic decompensation.…”

Fragmented QRS Predicts Cardiovascular Death of Patients With Structural Heart Disease and Inducible Ventricular Tachyarrhythmia

“…A final limitation is that we analyzed 98 patients treated between 1996 and 2011, a long time span that has included changes in the techniques and technologies involved in defibrillator device therapy. 29, 30 Our study population included only 5 patients with CRT-D.…”