Significant Increase in the Solubility of Celecoxib in Presence of Some Deep Eutectic Solvents as Novel Sustainable Solvents and the Thermodynamic Analysis of These Systems

Abstract

Background: Deep eutectic solvents (DESs) exist a wide variety of potential and existing applications. Based on the fact that the choline chloride (ChCl) is a complex B vitamin and widely used as food additive, the choline-based DESs are generically regarded as being harmless and non-toxic. In this regard, the low aqueous solubility of celecoxib (CLX) have been increased by use of DESs as neoteric class of solvents at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the ChCl/EG, U and G with the molar ratios: 1:2 and ChCl/MA with 1:1. The shake flask method was used to measure the solubility of CLX in the aqueous DESs solutions at different temperatures. Results: The solubility of the CLX increased with increasing the weight fraction of DESs. The observed solubility data was subjected to evaluate the relative performance of a number of models including Apelblat, Yalkowsky and Jouyban–Acree models for their correlation efficacy. Moreover, the apparent dissolution enthalpy, entropy and Gibbs free energy were obtained from the experimental solubility values. Conclusion: It was found that the solubility data was satisfactorily fitted using the mentioned models at different temperatures. The dissolution process of CLX in the studied solvent mixtures within investigated temperature range was endothermic, and the driving mechanism is the positive entropy.

Extraction of Natural Products by Direct Formation of Eutectic Systems

“…In addition to their applications in catalysis, , electrochemistry, , and metal processing, DESs have been used in chemical and biological syntheses. In particular, the use of DESs in dissolution, extraction, and separation has drawn the most attention, including in gas adsorption, metal-oxide dissolution, drug dissolution, biodiesel purification, and natural-product extraction . The traditional approach is to synthesize DESs and subsequently use them for dissolution and separation.…”

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

“…The applications and potential applications of deep eutectic solvents are immense, highlighting their use as solvents [ 33 ], as extraction solvents [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ], as electrolytes for lithium batteries [ 43 ], in nanotechnology [ 44 ], in gas capture [ 45 ], for the synthesis of new materials [ 46 , 47 , 48 ], in chromatography [ 38 , 49 ], for electrochemical analysis [ 50 ], in biomedical applications [ 51 ], for removing excess glycerol in biodiesel [ 52 ], and to mediate organic reactions [ 53 ]. More recently, deep eutectic solvents have been applied in the pharmaceutical industry with the aim of improving the bioavailability of drugs [ 54 ].…”

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

“…The applications and potential applications of deep eutectic solvents are immense, highlighting their use as solvents [38], extraction solvents [31,44,[48][49][50][51][52][53][54], electrolytes for lithium batteries [55], in nanotechnology [56], gas capture [57], for the synthesis of new materials [58-60], in chromatography [44,61], for electrochemical analysis [62], in biomedical applications [63], for removing excess glycerol in biodiesel [64]. More recently, deep eutectic solvents have been applied in the pharmaceutical industry with the aim of improving the bioavailability of drugs [65].…”