Significant publications on infectious diseases pharmacotherapy in 2013

Hunter, Andrew; Guervil, David J.; Perez, Katherine K.; Schilling, Amy N.; Verheyden, Collin N.; Vuong, Nancy N.; Xu, Ran

doi:10.2146/ajhp140148

Cited by 10 publications

(14 citation statements)

References 65 publications

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“…The low permeability shown by the outer membrane of Gram-negative bacteria, as well as the active efflux systems in the inner membrane generated by the pathogens to protect their intracellular functions, are known. However, the zwitterionic character of cefepime eases passage through the protein channels of the outer membrane, showing a broad spectrum against Gram-negative bacteria [3,4,5], and also good activity versus Gram-positive micro-organisms [6]. Alone, combined, or in a rotatory treatment, cefepime seems to be efficient against several bactericidal infections [7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of New Liposomes. Bactericidal Activity of Cefepime Encapsulated into Cationic Liposomes

et al. 2019

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Cefepime is an antibiotic with a broad spectrum of antimicrobial activity. However, this antibiotic has several side effects and a high degradation rate. For this reason, the preparation and characterization of new liposomes that are able to encapsulate this antibiotic seem to be an important research line in the pharmaceutical industry. Anionic and cationic liposomes were prepared and characterized. All cationic structures contained the same cationic surfactant, N,N,N-triethyl-N-(12-naphthoxydodecyl)ammonium. Results showed a better encapsulation-efficiency percentage (EE%) of cefepime in liposomes with phosphatidylcholine and cholesterol than with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). The presence of cholesterol and the quantity of egg-yolk phospholipid in the liposome increased the encapsulation percentage. The bactericidal activity against Escherichia coli of cefepime loaded into liposomes with phosphatidylcholine was measured. The inhibitory zone in an agar plate for free cefepime was similar to that obtained for loaded cefepime. The growth-rate constant of E. coli culture was also measured in working conditions. The liposome without any antibiotic exerted no influence in such a rate constant. All obtained results suggest that PC:CH:12NBr liposomes are biocompatible nanocarriers of cefepime that can be used in bacterial infections against Escherichia coli with high inhibitory activity.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of New Liposomes. Bactericidal Activity of Cefepime Encapsulated into Cationic Liposomes

et al. 2019

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“…Each year since 2009, the HIDN has led efforts to compile and review the top 10 significant publications in ID pharmacotherapy. [1][2][3][4][5][6][7][8][9] The purpose of this annual publication is to provide clinicians with an easily accessible summary of some of the most important developments in the field. Similar to previous years, at the end of 2018, HIDN members were asked to nominate articles thought to have most influenced ID pharmacotherapy practice in 2018, including those related to human immunodeficiency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

Significant Publications on Infectious Diseases Pharmacotherapy in 2018

Borjan

Gonzales-Luna

Carlson

et al. 2019

Journal of Pharmacy Practice

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Purpose: To summarize the top 10 most influential peer-reviewed infectious diseases (ID) pharmacotherapy articles published in the year 2018. Summary: Members of the Houston Infectious Diseases Network (HIDN) nominated articles that were thought to have most notably contributed to ID pharmacotherapy in 2018, including those related to human immunodeficiency virus (HIV). A total of 26 articles were nominated: 22 articles pertaining to general ID pharmacotherapy and 4 articles involving HIV/AIDS. To select the most significant articles of 2018, a survey was created and distributed to members of the Society of Infectious Diseases Pharmacists (SIDP) asking members to vote on their top 10 general ID publications and 1 HIV publication. Of the 462 members surveyed, 213 (46%) and 108 (23%) voted for general ID pharmacotherapy- and HIV-related articles, respectively. The top article(s) for both categories are summarized. Conclusion: With the increased emphasis on antimicrobial stewardship initiatives and the growing problem of multidrug-resistant (MDR) organisms, the amount of ID literature centered on stewardship, appropriate treatment durations, and newly approved antimicrobial agents continues to expand, making it challenging for clinicians to stay informed on the most relevant publications. This review summarizes significant ID-related publications in 2018 with the goal of aiding clinicians in staying up to date on the most noteworthy publications in ID pharmacotherapy.

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“…As a continuation of prior efforts to summarize important recent ID pharmacotherapy-related publications, [1][2][3][4][5][6][7][8] members were asked to nominate peer-reviewed articles that they believed most contributed to the practice of ID pharmacotherapy in 2017, including the areas of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). All nominated articles were published between January 1, 2017, and December 31, 2017, in prominent peerreviewed journals (eg, Antimicrobial Agents and Chemotherapy, Clinical Infectious Diseases, Journal of the American Medical Association).…”

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confidence: 99%