Significant toxic role for single-walled carbon nanotubes during normal embryogenesis

Roman, D.; Yasmeen, Amber; Mireuta, Matei; Stiharu, Ion; Moustafa, Ala‐Eddin Al

doi:10.1016/j.nano.2013.03.010

Cited by 39 publications

(32 citation statements)

References 28 publications

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“…138 It was also found that both single-walled and multi-walled carbon nanotubes adversely affected embryonic development. 139,140 In a recent study using C. elegans as an animal model, acute toxicity, including retarded growth, shortened life span and defective embryogenesis, and accumulated chronic toxicity were observed. 141 It is proposed that the geometry and agglomeration of carbon nanotubes, in addition to their metallic impurities, contribute to their toxicity.…”

Section: Toxicity Of Spherical Nanocarbon Materials-are Spherical Nanmentioning

confidence: 99%

Therapeutic applications of low-toxicity spherical nanocarbon materials

Wang

et al. 2014

NPG Asia Mater

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Nanocarbon materials have received considerable attention due to their unique structure and properties, which make them promising candidate materials for use in biomedical applications. In this review, we discuss the therapeutic applications of spherical nanocarbon materials, including fullerene nanoparticles, carbon nanohorn aggregates, nanodiamonds and porous carbon nanospheres, and their toxicology in biological systems. We put special emphasis on the antitumor effects of these multifunctional nanoparticles, which operate via novel mechanisms in a highly efficient manner. The low toxicities of these spherical nanocarbon materials as well as the possible effects of shape on toxicity are discussed.

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Section: Toxicity Of Spherical Nanocarbon Materials-are Spherical Nanmentioning

confidence: 99%

Therapeutic applications of low-toxicity spherical nanocarbon materials

Wang

et al. 2014

NPG Asia Mater

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“…64 On the other hand, our group has investigated the effect of SWCNTs on the chicken embryo at the third day of incubation. 28 We deposited 25 μg of SWCNTs, diluted in 25 μL of phosphate-buffered saline, on the embryos. We reported that SWCNTs treatment inhibits the angiogenesis of the chorioallantoic membrane and in the chicken embryo, especially in the brain and the liver (Figure 2).…”

Section: Swcnts and Avian Embryomentioning

confidence: 99%

“…This gap is even larger when considering their effects on embryonic development, for which only sparse data are available. [25][26][27][28][29][30] Most of these studies have focused on zebrafish embryo because it is easy to manipulate. However, other models were used to explore the effect of CNTs in the embryo such…”

Section: Introductionmentioning

confidence: 99%

Impact of single-walled carbon nanotubes on the embryo: a brief review

Moustafa¹,

Mfoumou²,

Roman³

et al. 2016

IJN

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Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. However, in the last few years, questions have been raised regarding the potential toxicity of CNTs to humans and the environment; it is believed that the physiochemical characteristics of these materials are key determinants of CNT interaction with living cells and hence determine their toxicity in humans and other organisms as well as their embryos. Thus, several recent studies, including ours, pointed out that CNTs have cytotoxic effects on human and animal cells, which occur via the alteration of key regulator genes of cell proliferation, apoptosis, survival, cell–cell adhesion, and angiogenesis. Meanwhile, few investigations revealed that CNTs could also be harmful to the normal development of the embryo. In this review, we will discuss the toxic role of single-walled CNTs in the embryo, which was recently explored by several groups including ours.

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“…There have been several reports in the literature demonstrating the toxicity of different CNPs in various biological embryo models, such as chicken, [16][17][18][19] zebrafish, [20][21][22][23][24][25] and Xenopus laevis. 26,27 For example, carbon nanotubes inhibited angiogenesis of the chorioallantoic membrane in chicken embryos and caused death before day 12 of the incubation period.…”

Section: Introductionmentioning

confidence: 99%

“…26,27 For example, carbon nanotubes inhibited angiogenesis of the chorioallantoic membrane in chicken embryos and caused death before day 12 of the incubation period. 19 Zebrafish embryos treated with nanodiamond (ND) were malformed in a dose-dependent manner. 28 However, no toxic effects were observed for fluorescent ND.…”

Section: Introductionmentioning

confidence: 99%

Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model

Kurantowicz

Sawosz

Halik

et al. 2017

IJN

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In the present study, the toxicity of six different types of carbon nanoparticles (CNPs) was investigated using a chicken-embryo model. Fertilized chicken eggs were divided into the following treatment groups: placebo, diamond NPs, graphite NPs, pristine graphene, small graphene oxide, large graphene oxide, and reduced graphene oxide. Experimental solutions at a concentration of 500 μg/mL were administrated into the egg albumin. Gross pathology and the rate of survival were examined after 5, 10, 15, and 20 days of incubation. After 20 days of incubation, blood samples were collected and the weight of the body and organs measured. The relative ratio of embryo survival decreased after treatment all treatments except diamond NPs. There was no correlation between the rate of survival and the ζ-potential or the surface charge of the CNPs in solution. Body and organ weight, red blood-cell morphology, blood serum biochemical parameters, and oxidative damage in the liver did not differ among the groups. These results indicate that CNPs can remain in blood circulation without any major side effects, suggesting their potential applicability as vehicles for drug delivery or active compounds per se. However, there is a need for further investigation of their properties, which vary depending on production methods and surface functionalization.

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Significant toxic role for single-walled carbon nanotubes during normal embryogenesis

Cited by 39 publications

References 28 publications

Therapeutic applications of low-toxicity spherical nanocarbon materials

Therapeutic applications of low-toxicity spherical nanocarbon materials

Impact of single-walled carbon nanotubes on the embryo: a brief review

Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model

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