Significantly elevated phosphatidylethanol levels in recent suicide attempters, but not in depressed controls and healthy volunteers

Strumila, Robertas; Lengvenyte, Aiste; Zdanavičius, Linas; Badaras, Robertas; Dlugauskas, Edgaras; Lesinskiene, Sigita; Matiekus, Eimantas; Marcinkevicius, Martynas; Vencevičienė, Lina; Utkus, Algirdas; Kaminskas, Arvydas; Petrėnas, Tomas; Songailienė, Jurgita; Ambrozaitytė, Laima

doi:10.1016/j.jpsychires.2022.12.043

Cited by 6 publications

(4 citation statements)

References 63 publications

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“…Twenty-three studies comprising 34 unique comparisons of inflammatory biomarkers in HC and patients with SB were included. CRP levels were higher in patients with SB versus HC across studies ( Al-Amarei et al, 2019 ; Ekinci and Ekinci, 2017 ;Gökalp et al, 2021 ;Huang et al, 2022 ;Kumar et al, 2021 ;Melhem et al, 2017 ;Priya et al, 2016 ;Strumila et al, 2023 ;Toffol et al, 2022 ;Ventorp et al, 2015 ;Yagci and Avci, 2021 ) (k = 11, SMD = 1.42, 95% CI = 0.85 and 1.98, p < 0.0001, I 2 = 92%, very large effect size, Fig. 4 A).…”

Section: Comparison Of Inflammatory Biomarkers In Hc and Patients Wit...mentioning

confidence: 87%

Immune-Related Biomarkers and Suicidal Behaviors: A Meta-Analysis

et al. 2022

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Section: Comparison Of Inflammatory Biomarkers In Hc and Patients Wit...mentioning

confidence: 87%

Immune-Related Biomarkers and Suicidal Behaviors: A Meta-Analysis

et al. 2022

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“…The study also collected information about alcohol use, smoking status, and sociodemographic variables including the length of education, income, and relationship status. Given that suicide attempters often underreport alcohol use [ 33 ], plasma phosphatidylethanol (PEth) level was used to measure alcohol exposure.…”

Section: Methodsmentioning

confidence: 99%

Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity

Strumila,

Lengvenyte,

Zdanavicius

et al. 2024

Comprehensive Psychoneuroendocrinology

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“…weight decrease, self-outlook, and quality of mood . Anxious symptoms: anxious mood, somatic complaints, sympathetic arousal, panic/phobic symptoms, and gastrointestinal symptoms [0][1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]…”

Section: Supplementary Filesmentioning

confidence: 99%

“…Elevated blood concentrations of classic in ammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), are well-documented in MDD and BD 9,10 . Notably, these elevated pro-in ammatory markers have been speci cally linked with STB, above-and beyond the association with depression [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Plasma Inflammation and Plasticity Biomarkers Associated with Future Suicidal Ideation and Depression Severity in Mood Disorders: A Six-Month Prospective Study

Lengvenyte

Cognasse²,

Hamzeh‐Cognasse³

et al. 2023

Preprint

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Discerning potential associations between plasma biomarkers and the evolution of suicidal ideation (SI) in mood disorders could advance our understanding of disease progression. We evaluated a cohort of 149 mood disorder patients, assessing 32 plasma soluble proteins implicated in neuroplasticity and inflammation at baseline and six-month follow-up. The primary outcome was the occurrence of suicidal ideation during the six-month follow-up. Secondary outcomes included the presence of suicidal ideation and depression severity at six-month follow-up. We employed Principal Component Analysis and Elastic Net regression for feature extraction and selection. Selected markers were then examined in covariate-adjusted regression models. Our results showed that high baseline levels of interferon-γ and a pro-inflammatory principal component score were linked to the occurrence of SI during follow-up. At the six-month point, SI presence was associated with elevated interferon-γ, interleukin-1β, and diminished serotonin levels, with the latter connection dissipating post-adjustment. High interferon-γ, and low orexin-A at baseline were associated with increased depression severity at follow-up, with specific associations between interferon-γ and anxious symptoms, and orexin-A and atypical depressive symptoms. These findings identify elevated interferon-γ, interleukin-1β, and reduced orexin-A as potential biomarkers associated with the occurrence of SI and severity of depression in mood disorders over six months. With further validation in larger cohorts, these insights could enable more personalized risk assessment and intervention strategies, representing a step forward in improving therapeutic outcomes.

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Significantly elevated phosphatidylethanol levels in recent suicide attempters, but not in depressed controls and healthy volunteers

Cited by 6 publications

References 63 publications

Immune-Related Biomarkers and Suicidal Behaviors: A Meta-Analysis

Immune-Related Biomarkers and Suicidal Behaviors: A Meta-Analysis

Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity

Plasma Inflammation and Plasticity Biomarkers Associated with Future Suicidal Ideation and Depression Severity in Mood Disorders: A Six-Month Prospective Study

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