Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon

Roustit, Matthieu; Hellmann, Marcin; Cracowski, Claire; Blaise, S.

doi:10.1038/clpt.2011.302

Cited by 25 publications

(14 citation statements)

References 28 publications

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“…There is a continuous search for new car diovascular indications, and in animal studies PDE5 inhibitors have proven to be protective in congestive heart failure, ischaemic heart disease 199,200 , peripheral artery disease 201 and doxorubicin cardiomyopathy 202 . Moreover, in smaller clinical trials, PDE5 inhibitors have been shown to attenuate vasoconstriction in Raynaud phenomenon 203 .…”

Section: Ace Inhibitors and At1 Blockersmentioning

confidence: 99%

Strategies to increase nitric oxide signalling in cardiovascular disease

Lundberg

Gladwin

Weitzberg

2015

Nat Rev Drug Discov

476

381

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Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central nervous systems, and crucial steps in the regulation of NO bioavailability in health and disease are well characterized. Although early approaches to therapeutically modulate NO bioavailability failed in clinical trials, an enhanced understanding of fundamental subcellular signalling has enabled a range of novel therapeutic approaches to be identified. These include the identification of: new pathways for enhancing NO synthase activity; ways to amplify the nitrate-nitrite-NO pathway; novel classes of NO-donating drugs; drugs that limit NO metabolism through effects on reactive oxygen species; and ways to modulate downstream phosphodiesterases and soluble guanylyl cyclases. In this Review, we discuss these latest developments, with a focus on cardiovascular disease.

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Section: Ace Inhibitors and At1 Blockersmentioning

confidence: 99%

Strategies to increase nitric oxide signalling in cardiovascular disease

Lundberg

Gladwin

Weitzberg

2015

Nat Rev Drug Discov

476

381

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“…e subjects were asked not to drink any alcohol or not to use any other stimulants during the testing period. Women were excluded from the study because differences in the hormone economy induce differences in regular flows and the provoked ones [30]. e participants were randomly divided into two groups with 24 people in each of them.…”

Section: Methodsmentioning

confidence: 99%

Influence of 8-Week Aerobic Training on the Skin Microcirculation in Patients with Ischaemic Heart Disease

Szyguła

Wierzbicka

Sondel

2020

Journal of Aging Research

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Aim of the paper. Microvascular functional impairment in the skin is considered an early predictor of developing cardiovascular diseases and a recognised risk factor of IHD. This is why the aim of the study is investigating if 8-week aerobic training will improve reactivity of skin microcirculation and the function of endothelium in patients with IHD and if the potential improvement will last with lack of physical activity. Materials and Methods. In the study, 48 men took part with a stabilized and pharmacologically controlled ischaemic disease. The participants were randomly divided into two groups with 24 people in each of them. The research group participated in an aerobic march training. The march was taking place 3 times a week for 30–40 minutes over a period of 8 weeks. In the time of training, the subjects did not practise any other physical activity for 8 weeks. The measurement of skin microcirculation was done by using the laser Doppler flowmeter estimating the values of regular flow and the reactions provoked in response to occlusion and temperature. Signal frequency was also analysed which was received by means of laser Doppler flowmetry in the range from 0.01 to 2 Hz during the regular flow. Results. During the first measurement in relation to the initial values, a decrease in body mass was noted by 2.21 kg on average as well as reduction of systolic and diastolic pressure by 10.4 mmHg and 3.68 mmHg, respectively. The regular flow (RF) increased after the training by 2.21%. The provoked reactions were as follows: hyperemic (PRHmax): an increase occurred by 8.76% and hyperthermic (THmax): an increase occurred by 5.38%. The time needed to achieve PRHmax was reduced by 42% and to achieve THmax, by 22%. The heart rhythm and the signal strength of neurogenic rhythm decreased by approximately 8% and 24%, respectively. The signal strength of endothelial rhythm increased by 19%. In the second measurement, a recourse was noted in the values of indicators under investigation, which were assuming values close to the initial ones. In the control group, the measurement values did not change significantly. Conclusions. 8 weeks of systematic aerobic training provides a significant improvement of endothelium functioning, expressed by reactivity improvement in skin microcirculation in patients suffering from ischaemic heart disease. It points to aerobic training as a nonpharmacological effective cardioprotective factor. The improvement effects of skin vascular bed functioning in the group of patients with IHD are impermanent, and they disappear after the period in which patients did not exercise physical activity.

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“…This leads to increased endogenous nitric oxide levels, with subsequent vasodilation. 32 Several PDE5 inhibitors have been proposed in the treatment of SSc-associated vasculopathy, and in the literature three uncontrolled pilot studies have highlighted the beneficial effect of sildenafil on DU healing and its safety. [33][34][35] A meta-analysis of three RCTs investigated various selective PDE5 inhibitors:sildenafil 50 mg twice a day, 36 modified-release sildenafil 100 mg/day increased up to 200 mg/day, 37 and tadalafil 20 mg on alternate days.…”

Section: Prostanoidsmentioning

confidence: 99%

<p>Management of digital ulcers in systemic sclerosis</p>

Barsotti¹,

Battista²,

Venturini³

et al. 2019

CWCMR

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Systemic sclerosis (SSc) is a rare disease characterized by autoimmune pathogenesis, alterations to the vascular system, and fibrosis of the skin and internal organs. Digital ulcers (DUs) are common in SSc patients, and represent a major burden for the patients. The management of DUs in systemic sclerosis is difficult, because it needs a multimodal therapeutic approach, as local treatment alone is usually insufficient and also systemic treatment with vasoactive drugs and modification of the lifestyle are usually required for healing of the wounds. In this review, we describe the optimal management of DUs according to recent literature and our clinical practice for systemic and local treatment of chronic digital wounds in SSc patients.

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Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon

Cited by 25 publications

References 28 publications

Strategies to increase nitric oxide signalling in cardiovascular disease

Strategies to increase nitric oxide signalling in cardiovascular disease

Influence of 8-Week Aerobic Training on the Skin Microcirculation in Patients with Ischaemic Heart Disease

<p>Management of digital ulcers in systemic sclerosis</p>

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