Sildenafil no tratamento da hipertensão pulmonar após cirurgia cardíaca

Abstract

Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery.Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In postoperative the newborn had pulmonary hypertension and persistent hypoxia, without response to nitric oxide, but with improved oxygenation after continuous intravenous infusion of prostaglandin E1. After several failed attempts to discontinue prostaglandin E1, oral sildenafil was used. There was a decrease in pulmonary vascular resistance with consequent oxygenation improvement and 48 hours later it was possible to discontinue prostaglandin E1 infusion.Comments: Sildenafil can be an alternative therapy for pulmonary hypertension, especially when there is no response to conventional therapy.J Pediatr (Rio J). 2005;81(2):175-8: Sildenafil, pulmonary hypertension, prostaglandin.

Hipertensão Pulmonar Em Cães: Artigo De Revisão

“…O tratamento objetiva a estabilização cardiovascular, melhora da oxigenação e redução da pressão arterial pulmonar (Bentlin et al, 2005). Sempre que possível o tratamento é direcionado à eliminação da causa primária.…”

Treatment of pulmonary arterial hypertension

“…Portanto, existem muitos questionamentos quanto à real eficácia do sildenafil no tratamento (agudo e crônico) de pacientes portadores de HP, bem como a necessidade do estabelecimento de dose, intervalo e segurança para sua utilização no paciente pediátrico. 65 .…”