Silencing long non-coding RNA zinc finger antisense 1 restricts secondary cerebral edema and neuron injuries after traumatic brain injury

Feng, Jingyuan; Zhou, Zhongwu; Feng, Ruizhi; Zeng, Chunhui; Wei, Minjun; Hong, Tao

doi:10.1016/j.neulet.2021.135958

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…Identically, it has been reported ZFAS1 triggers the aggravation of ischemia-induced cardiac function impairment [ 39 ]. Moreover, Yuan et al have reported that ZFAS1 is associated with bupivacaine-induced neurotoxicity [ 43 ]. Compared with such a finding, our research further demonstrated the repressive role of ZFAS1 in FCI development with the combination of miR- miR-144-5p/FGF7 axis, expanding the internal mechanism of ZFAS1 in neurological function.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Inhibition of Long non-coding RNA zinc finger antisense 1 improves functional recovery and angiogenesis after focal cerebral ischemia via microRNA-144-5p/fibroblast growth factor 7 axis

Qing

Deng

et al. 2022

Bioengineered

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Long non-coding RNA zinc finger antisense 1 (ZFAS1) has been probed in cerebral ischemia, while the regulatory mechanism of ZFAS1 in focal cerebral ischemia (FCI) via binding to microRNA (miR)-144-5p remains rarely explored. This study aims to decipher the function of ZFAS1 on FCI via sponging miR-144-5p to modulate fibroblast growth factor 7 (FGF7). The focal cerebral ischemia rat model was established by occlusion of the middle cerebral artery (MCAO) Lentivirus vectors altering ZFAS1, miR-144-5p or FGF7 expression were injected into rats before MCAO. Then, ZFAS1, miR-144-5p, and FGF7 levels were detected, the inflammatory factor level, oxidative stress level, angiogenesis, neurological function injury and neuronal apoptosis were assessed. The binding relations among ZFAS1, miR-144-5p and FGF7 were validated. ZFAS1 and FGF7 expression was elevated, while miR-144-5p expression was reduced in FCI rats. Decreased ZFAS1 or FGF7 or enriched miR-144-5p repressed the inflammatory response, oxidative stress, neuronal apoptosis, while it improved angiogenesis, and neurological function recovery; while up-regulated ZFAS1 exerted opposite effects. The augmented miR-144-5p or silenced FGF7 reversed the effects of enriched ZFAS1. ZFAS1 sponged miR-144-5p that targeted FGF7. Inhibition of lncRNA ZFAS1 improves functional recovery and angiogenesis after FCI via miR-144-5p/FGF7 axis. This study provides novel therapeutic targets for FCI treatment.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Inhibition of Long non-coding RNA zinc finger antisense 1 improves functional recovery and angiogenesis after focal cerebral ischemia via microRNA-144-5p/fibroblast growth factor 7 axis

Qing

Deng

et al. 2022

Bioengineered

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“… 24 Silencing lncRNA ZFAS1 regulates the recovery of neurological function in traumatic brain injury. 25 In the AIS cell model, lncRNA ZFAS1 attenuates cell damage by upregulating pro‐survival protein myeloid cell leukemia‐1 (MCL‐1) by sponging miR‐186‐5p. 19 However, the relationship between lncRNA ZFAS1 expression, disease risk, and neurological impairment in AIS patients is still not fully understood.…”

Section: Discussionmentioning

confidence: 99%

The role of blood lnc‐ZFAS1 in acute ischemic stroke: correlation with neurological impairment, inflammation, and survival profiles

Wang

Zhou

Zhong

et al. 2021

Clinical Laboratory Analysis

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“…The expression of ZFAS1 is upregulated in TBI mice ( Wang et al, 2017 ). The knockdown of ZFAS1 inhibited apoptosis and inflammation and attenuated brain edema and neuronal injury ( Feng et al, 2021 ). Brain edema, an important prognostic factor, is a key challenge in the treatment of TBI ( Winkler et al, 2016 ).…”

Section: Role Of Inflammation and Immune Responses In Traumatic Brain...mentioning

confidence: 99%

“…Long Non-coding RNA Zinc Finger X-Chromosomal Protein Antisense 1 Zinc finger X-chromosomal protein antisense 1 (ZFAS1) is derived from the antisense transcription of zinc-containing ferredoxin-1 (ZFX1) located on chromosome 20q13.13 (Dong et al, 2018). Previous studies have reported that ZFAS1 is associated with the development and progression of various cancers (Feng et al, 2021). ZFAS1 contains snoRNAs (Snord12, Snord12b, and Snord12c) (Askarian-Amiri et al, 2011).…”

Section: Long Non-coding Rna Colorectal Neoplasia Differentially Expr...mentioning

confidence: 99%

Research Progress on the Inflammatory Effects of Long Non-coding RNA in Traumatic Brain Injury

Wang

Ding

et al. 2022

Front. Mol. Neurosci.

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Globally, traumatic brain injury (TBI) is an acute clinical event and an important cause of death and long-term disability. However, the underlying mechanism of the pathophysiological has not been fully elucidated and the lack of effective treatment a huge burden to individuals, families, and society. Several studies have shown that long non-coding RNAs (lncRNAs) might play a crucial role in TBI; they are abundant in the central nervous system (CNS) and participate in a variety of pathophysiological processes, including oxidative stress, inflammation, apoptosis, blood-brain barrier protection, angiogenesis, and neurogenesis. Some lncRNAs modulate multiple therapeutic targets after TBI, including inflammation, thus, these lncRNAs have tremendous therapeutic potential for TBI, as they are promising biomarkers for TBI diagnosis, treatment, and prognosis prediction. This review discusses the differential expression of different lncRNAs in brain tissue during TBI, which is likely related to the physiological and pathological processes involved in TBI. These findings may provide new targets for further scientific research on the molecular mechanisms of TBI and potential therapeutic interventions.

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Silencing long non-coding RNA zinc finger antisense 1 restricts secondary cerebral edema and neuron injuries after traumatic brain injury

Cited by 13 publications

References 34 publications

RETRACTED ARTICLE: Inhibition of Long non-coding RNA zinc finger antisense 1 improves functional recovery and angiogenesis after focal cerebral ischemia via microRNA-144-5p/fibroblast growth factor 7 axis

RETRACTED ARTICLE: Inhibition of Long non-coding RNA zinc finger antisense 1 improves functional recovery and angiogenesis after focal cerebral ischemia via microRNA-144-5p/fibroblast growth factor 7 axis

The role of blood lnc‐ZFAS1 in acute ischemic stroke: correlation with neurological impairment, inflammation, and survival profiles

Research Progress on the Inflammatory Effects of Long Non-coding RNA in Traumatic Brain Injury

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