2024
DOI: 10.1167/iovs.65.13.9
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Silencing METTL3 Increases HSP70 Expression and Alleviates Fibrosis in Keratocytes

Yapeng Jing,
Jun Li,
Peng Hao
et al.

Abstract: Purpose To explore the potential role of N 6 -methyladenosine (m6A) and its regulatory factors in corneal fibrosis response using both in vivo and in vitro models. Methods This study utilized the C57BL/6 mouse corneal alkali burn as an in vivo model and stimulated keratocytes with transforming growth factor beta 1 (TGF-β1) in vitro. Small interfering RNA (siRNA) was employed to downregulate the expression of YTH domain family me… Show more

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