Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy

Kamal, Mohamed M.; Ammar, Reham A.; Kassem, Dina H.

doi:10.1016/j.lfs.2024.122579

Life Sciences

2024

DOI: 10.1016/j.lfs.2024.122579

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Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy

Mohamed M. Kamal,

Reham A. Ammar,

Dina H. Kassem

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Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

Ghasemi Gojani,

Rai,

Norouzkhani

et al. 2024

CIMB

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The β-cells within the pancreas play a pivotal role in insulin production and secretion, responding to fluctuations in blood glucose levels. However, factors like obesity, dietary habits, and prolonged insulin resistance can compromise β-cell function, contributing to the development of Type 2 Diabetes (T2D). A critical aspect of this dysfunction involves β-cell dedifferentiation and transdifferentiation, wherein these cells lose their specialized characteristics and adopt different identities, notably transitioning towards progenitor or other pancreatic cell types like α-cells. This process significantly contributes to β-cell malfunction and the progression of T2D, often surpassing the impact of outright β-cell loss. Alterations in the expressions of specific genes and transcription factors unique to β-cells, along with epigenetic modifications and environmental factors such as inflammation, oxidative stress, and mitochondrial dysfunction, underpin the occurrence of β-cell dedifferentiation and the onset of T2D. Recent research underscores the potential therapeutic value for targeting β-cell dedifferentiation to manage T2D effectively. In this review, we aim to dissect the intricate mechanisms governing β-cell dedifferentiation and explore the therapeutic avenues stemming from these insights.

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Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

Ghasemi Gojani,

Rai,

Norouzkhani

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

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Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy

Cited by 1 publication

References 67 publications

Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

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