Silent information regulator 1 mediates hippocampal plasticity through presenilin1

A Novel Approach to Assess the Dynamics of Extra-Chromosomal Circular Ribosomal DNA in Human Cells

“…To draw first conclusions about rn5s1, we determined the transcriptional activity of rn5s1 and rna45s5, as well as sirt1, in HEK-293 cells in response to resveratrol (non-significant trends in MCF7 & SH-SY5Y) ( Figure 1A). Consistent with previous work [3,4], we found relevant transcriptional increases of sirt1 itself (1.9-fold) but also rna45s5 (1.8 fold) and rn5s1 (3.5 fold) suggesting parallel regulation and presence of SIRT protein at both rDNA loci.…”

“…Among the signaling cues that activate SIRT1 pathways, is the polyphenol molecule resveratrol. SIRT1 activation by resveratrol triggers a broad range of transcription factors and co-regulators that mediate key mechanisms in the cell cycle, cell growth and apoptotic and autophagic programs of cell death [2][3][4]. Other intracellular mechanisms activated by SIRT1-dependent *Correspondence: Leheste ISSN: pathways are those related to DNA stability and DNA replication.…”

Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation

“…This particular dose (i.e., 10 lM) of resveratrol was determined from in vitro studies using human cells (Torres et al, 2011). DMSO (the vehicle solution) was delivered at the same rate and at a similar volume to that of resveratrol to the STN of the non-resveratrol treated hemisphere.…”

“…To determine the effects of peripheral resveratrol administration on astrocytic gliosis and scar formation within the STN, expression changes of genes related to cell division cycle, apoptosis and neurodegeneration were assessed via QPCR (Torres et al, 2011). The following genes were selected: bcl-1 (cyclin D1), bad (BCL-2 antagonist of cell death), bak (BCL-2 antagonist killer 1), bcl-2 (oncogene B-cell leukemia 2), casp-3 (caspase 3), gpr-30 (G protein-coupled receptor 30), faim (Fas apoptotic inhibitory molecule), p53 (transformation-related protein 53), and park-2 (parkin).…”

Histone Acetylation and Deacetylation

“…However, a recent report has provided strong evidence that a reduced SIRT1 activity results in histone acetylation at the promoter region of the gene encoding presenilin1, thus increasing its transcription and the downstream expression of the protein, PSEN1. These effects are further thought to underlie Alzheimer's disease-related deficits in neuronal plasticity [195]. Similarly, the maintenance of transcriptional inactivity may be regulated by SIRT1 histone deacetylation through additional chromatin modification.…”