Silica‐based Ceramics: Mesoporous Silica

Colilla, Montserrat

doi:10.1002/9781118406748.ch5

Cited by 5 publications

(3 citation statements)

References 191 publications

(293 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ordered mesoporous silica (SiO 2 ) with pore sizes between 2 and 50 nm and silica-ceramic materials have attracted significant interest as porous sorbents for environmental applications due to their low toxicity, structural stability, and chemical resistance . Mesoporous silica functionalized with metal-chelate ligands showed excellent anion exchange behavior for arsenate, molybdate, and chromate. , Silica gels have been modified with siloxane (Si–O–Si) or silanol groups (Si–OH) to enhance hydroxyl functionalities and provide coordination sites for binding of phosphate.…”

Section: Nanoporous Sorbents For the Removal And Recovery Of Pmentioning

confidence: 99%

Nanoporous Sorbents for the Removal and Recovery of Phosphorus from Eutrophic Waters: Sustainability Challenges and Solutions

Othman

Dumitrescu

Andreescu

et al. 2018

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Increased industrial and agricultural activity has affected the availability of phosphorus (P) in nature and has caused a significant imbalance in the P cycle with long-term consequences on ecosystem health and sustainability. While P is an essential element for food production as well as plant and animal nutrition, it is also a limited nonrenewable resource whose availability is expected to decrease in the next century. Widespread application of P-based fertilizers and their excessive accumulation in water bodies leads to eutrophication which is associated with overgrowth of harmful algal blooms and degradation of water quality. This paper provides an overview of contemporary challenges and methodologies for improving P use efficiency and sustainability in the environment. Technologies and processes for the removal of P-containing compounds from water through the use of functional nanomaterial sorbents with tailored surface properties for capture, removal, and recycling are described. Various classes of materials including carbon-based, zeolites, mesoporous silica, metal organic frameworks, metal oxides and hydroxides, biomass-derived materials, and P-binding receptors are reviewed along with their properties, binding affinity, and adsorption capacity. The potential of these materials to control the amount of P in the environment and create decision support tools for water resource management is also discussed, with examples of applications.

show abstract

Section: Nanoporous Sorbents For the Removal And Recovery Of Pmentioning

confidence: 99%

Nanoporous Sorbents for the Removal and Recovery of Phosphorus from Eutrophic Waters: Sustainability Challenges and Solutions

Othman

Dumitrescu

Andreescu

et al. 2018

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…In addition, positively charged MSNs should be able to facilitate Hyal loading through electrostatic interactions. However, the average pore sizes of MSNs are usually in the range of 2−3 nm, 16 too small to allow Hyal to permeate into the mesoporous cavities. Furthermore, MSNs normally possess negative surface charges, hindering the effective loading of Hyal.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Biomimetic Nanosystem Based on Large-Pore Mesoporous Silica Nanoparticles with High Hyaluronidase Loading for Tumor Deep Penetration

Song

Qiu

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Loading hyaluronidase (Hyal) in a nanocarrier is a potent strategy to degrade the tumor extracellular matrix for tumor deep penetration and enhanced tumor therapy. Herein, a pH-sensitive biomimicking nanosystem with high Hyal loading, effective tumor targeting, and controllable release is constructed. Specifically, cationic mesoporous silica nanoparticles (CMSNs) with large pores 13.52 nm in diameter were synthesized in a one-pot manner by adding N-[3-trimethoxysilylpropyl]-N,N,N-trimethylammonium to a reversed microemulsion reaction system. The Hyal loading rate was as high as 19.47% owing to matched pore size and the cationic surface charge. Subsequently, a pH-sensitive biomimetic hybrid membrane (pHH) composed of pH-sensitive liposome (pHL), red blood cell membrane, and pancreatic cancer cell membrane was camouflaged on the pHL-coated and doxorubicin/Hyal-loaded CMSNs (shortened as DHCM). The DHCM@pHL@pHH is stable at neutral pH while it releases the payloads smoothly in the tumor acidic microenvironment. Consequently, it can escape from macrophage clearance, be specifically taken up by pancreatic cancer cells, and efficiently accumulate at the tumor site. More importantly, it can penetrate deeply in pancreatic tumors with a tumor growth inhibition ratio of 80.46%. The nanosystem is biocompatible and has potential for clinical transformation, and the nanocarrier is promisingly applicable as a platform for encapsulation of various macromolecules for smart and tumor-targeted delivery.

show abstract

“…Among inorganic nanomaterials, mesoporous silica NPs (MSNs) are one of the most promising drug carriers, and they have attracted increasing attention in fields such as drug delivery, diagnostic and medical imaging and engineering due their unique properties ( Figure 2 ) including: large surface area (~1000 m 2 ·g −1 for MCM-41 type particles) and large pore volumes (~1 cm 3 ·g −1 ) providing high loading capacity, high degree of tunability regarding size, morphology and pore diameter, biocompatibility, biodistribution, biodegradation and excretion [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Another added advantage is the ease of synthesis showing a great variety of morphologies and surface functionalities using different strategies which have been reviewed elsewhere [ 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Smart Mesoporous Nanomaterials for Antitumor Therapy

2015

Self Cite

View full text Add to dashboard Cite

Abstract:The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, transport and protect drug molecules until the target is reached. It is possible to incorporate different targeting ligands to the outermost surface of MSNs to selectively drive the drugs to the tumour tissues. To prevent the premature release of the cargo entrapped in the mesopores, it is feasible to cap the pore entrances using stimuli-responsive nanogates. Therefore, upon exposure to internal (pH, enzymes, glutathione, etc.) or external (temperature, light, magnetic field, etc.) stimuli, the pore opening takes place and the release of the entrapped cargo occurs. These smart MSNs are capable of selectively reaching and accumulating at the target tissue and releasing the entrapped drug in a specific and controlled fashion, constituting a promising alternative to conventional chemotherapy, which is typically associated with undesired side effects. In this review, we overview the recent advances reported by the scientific community in developing MSNs for antitumor therapy. We highlight the possibility to design multifunctional nanosystems using different therapeutic approaches aimed at increasing the efficacy of the antitumor treatment.

show abstract

Silica‐based Ceramics: Mesoporous Silica

Cited by 5 publications

References 191 publications

Nanoporous Sorbents for the Removal and Recovery of Phosphorus from Eutrophic Waters: Sustainability Challenges and Solutions

Nanoporous Sorbents for the Removal and Recovery of Phosphorus from Eutrophic Waters: Sustainability Challenges and Solutions

pH-Sensitive Biomimetic Nanosystem Based on Large-Pore Mesoporous Silica Nanoparticles with High Hyaluronidase Loading for Tumor Deep Penetration

Smart Mesoporous Nanomaterials for Antitumor Therapy

Contact Info

Product

Resources

About