Silica Catalyst Promoted One-Pot Synthesis of 4-[(Dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione

Complex reaction kinetics of a Mannich reaction in droplets under electrospray conditions

“…52 Catalysts for this reaction range from strong inorganic acids or bases to transition metal complexes or organocatalysts, which reached high yields in one to several hours in a batch reaction. [53][54][55][56] Shorter reaction times for the Mannich reaction with high yields can be found under continuous-flow conditions (415 min), 57,58 for a thin film reaction at ambient surface (410 min) 50 and for the combination of a microchip with nanospray MS (43 min). 59 One example shows how the reaction pathway can even change by reducing the size the reaction vessel.…”