Silica Nanoparticles as a Potential Carrier for Doxycycline Hyclate

Abstract

S ILICA nanoparticles (SiO 2 NPs) have found applications in many advanced biomedical fields. This research work is concerned with the preparation of amorphous silica nanoparticles by the hydrolysis of tetraethyl orthosilicate (TEOS) in ethanol medium and different surfactants such as cetyltrimethylammonium bromide (CTAB) and polyvinylpyrrolidone (PVP) and study the final properties of the prepared silica nanoparticles. The synthesized nanoparticles were systematically characterized by XRD, FTIR, particle size analysis and TEM. The XRD results revealed the crystallinity of silica nanoparticles. FTIR spectroscopy confirmed the presence of Si-O in the sample. The data obtained from DLS showed that particles with size of 198 nm had prepared. Moreover, the cytotoxicity of blanked silica NPs and Doxycycline Hyclate (DOX) loaded silica NPs on Human bone osteosarcoma cells (Saos-2) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results approved that the fabricated Silica nano particles are biocompatible and have the potential to be a convenient drug carrier.

Application of Silica Nanoparticles in Combination with Two Bacterial Strains Improves the Growth, Antioxidant Capacity and Production of Barley Irrigated with Saline Water in Salt-Affected Soil

“…Yet, the combined application of PGPR and SiNPs showed greater potential regarding the activity of antioxidant enzymes, resulting in a further increase in the SOD, CAT, and POX activities. The conversion of H 2 O 2 into non-toxic compounds (i.e., H 2 O and O 2 ) protects the plants against the harmful impacts of H 2 O 2 on the cell membranes and macromolecules [ 46 , 47 ]. Our results illustrated a distinguished decrease in the H 2 O 2 contents due to the sole application of PGPR and SiNPs and a reduction in lipid peroxidation (MDA) compared to control plants [ 48 ].…”