Silica-nanosphere-based organic–inorganic hybrid nanomaterials: synthesis, functionalization and applications in catalysis

Sharma, Rakesh Kumar; Sharma, Shivani; Dutta, Sriparna; Zbořil, Radek; Gawande, Manoj B.

doi:10.1039/c5gc00381d

Cited by 205 publications

(127 citation statements)

References 184 publications

(174 reference statements)

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“…In continuation of our efforts for synthesis of organic compounds using sustainable protocols (Gawande et al, 2013a,b,c,d, 2014a,b,c; Kale et al, 2013; Sharma et al, 2015), in this work, we have successfully developed a mild and ecofriendly synthesis of benzyl phosphonates using PEG/KI as a catalytic system. In this protocol, PEG not only acts as a reaction medium but also as a PTC.…”

Section: Resultsmentioning

confidence: 94%

A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System

et al. 2016

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An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K2CO3 as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K2CO3 in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations.

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Section: Resultsmentioning

confidence: 94%

A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System

et al. 2016

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“…Recently, the use of nanocatalysts has increased rapidly and has resulted in the development of several active and efficient nanocatalysts for various protocols [8][9][10][11][12][13][14][15][16][17][18]. These systems have several advantages over conventional catalysts, such as superior activity and improved stability.…”

Section: Introductionmentioning

confidence: 99%

Ionic liquid immobilized onto fibrous nano-silica: A highly active and reusable catalyst for the synthesis of quinazoline-2,4(1H,3H)-diones

Sadeghzadeh¹

2015

Catalysis Communications

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“…in situ removal of water and moisture absorbing materials are the two options [25][26][27], which were often observed with minimum success and inconsistent yields [25][26][27]. Recent mechanism studies had suggested that moisture was not the real problem and the catalysts offering more surface area have proven to be more useful [28][29][30][31]. The use of Fe 3 O 4 @SiO 2 was first of its sort and near doubling of reaction yield is in expected lines considering our similar observation with thiophenes, terpyridine, quinazoline and isoxazole [23].…”

Section: Synthesis Of 2-amino-5-carboethoxy-4-hydroxypyrimidine Withoutmentioning

confidence: 99%

Synthesis and Microbicidal Activity of Substituted 1,2,3-Triazoles having Amide and Hydroxy Functionality

Kaushik¹,

Luxmi²

2017

Asian J. Chem.

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Pyrimidines and pyridines are choice for modern day medicinal chemistry. Pyrimidine synthons are synthesized form guanidine and different substituted malonates. One of such pyrimidine ring synthon is 2-amino-5-carboethoxy-4-hydroxy pyrimidine. The commercially deployed synthesis involved a mixture of KOH and guanidine carbonate and gradual temperature controlled addition of diethylethoxy methylene melonate giving a yellow precipitate. The precipitate is cooled to around 5 °C and recrystallized from ethanol-water mixture. Though purity is never an issue in this popular process, yields are very low (70-75 %). The GC analysis of reaction mixture indicated that almost starting material was left unreacted and the first yellow precipitate formation is the rate determining step. We report silica functionalized magnetic particles as material support for synthesis of 2-amino-5carboethoxy-4-hydroxy pyrimidine. The cyclization reaction yields are reported to be enhanced due to presence of "near-homogeneous" nanomaterial catalyst. The prominent catalyst of interest to us is Fe3O4@SiO2 of 40 nm size. The particles are produced by modified Stober process giving consistent yields and coating of SiO2. The structural characterization is performed with SEM, TEM, IR and the data are consistent across multiple batches. The use of 40 nm size Fe3O4@SiO2 enabled higher yields of cyclization step in synthesis of 2-amino-5-carboethoxy-4-hydroxy pyrimidine. The mechanism of catalysis is stabilization of hetero atoms on the acidic silica surface and hence formation of pyrimidine. The study with different sized nanoparticles has indicated 40 nm size seems to be optimum and ability of catalysis is reduced as the size of nanoparticles has increased. The reaction performed at different batch sizes has indicated that 5 % (w/v) catalyst is optimal in the reaction. This process modification has far reaching applications in medicinal chemistry and bulk drug synthesis.

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Silica-nanosphere-based organic–inorganic hybrid nanomaterials: synthesis, functionalization and applications in catalysis

Abstract: SHARMA, S.; DUTTA, S.; ZBORIL, R.; GAWANDE, M. B.; Green Chem. 17 (2015) 6, 3207-3230, http://dx.doi.org/10.1039/C5GC00381D ; Dep. Chem., Univ. Delhi, Delhi 110 007, India; Eng.) -S. Adam 32-262

Cited by 205 publications

References 184 publications

A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System

A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System

Ionic liquid immobilized onto fibrous nano-silica: A highly active and reusable catalyst for the synthesis of quinazoline-2,4(1H,3H)-diones

Synthesis and Microbicidal Activity of Substituted 1,2,3-Triazoles having Amide and Hydroxy Functionality

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