Silica particles coated with zwitterionic polymer brush: Formation of colloidal crystals and anti-biofouling properties in aqueous medium

Suzuki, Hisatomo; Murou, Masanobu; Kitano, Hiromi; Ohno, Kohji; Saruwatari, Yoshiyuki

doi:10.1016/j.colsurfb.2010.12.023

Cited by 38 publications

(21 citation statements)

References 36 publications

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“…The most widely used method to graft zwitterionic polymers to bioceramic surfaces is the surface-initiated atom transfer radical polymerization (SI-ATRP) [38]. This method has been used to coat silica NPs with poly(sulfobetaine) (pSB) (structure 6, Figure 2) [39] and polycarboxybetaine (pCB) derivatives [40,41]. Alternatively, surface reversible addition-fragmentation chain transfer (RAFT) polymerization has been used to graft SB copolymers from mesoporous silica nanoparticles (MSNPs) [42].…”

Section: Functionalization With Zwitterionic Polymersmentioning

confidence: 99%

Zwitterionic ceramics for biomedical applications

2016

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Section: Functionalization With Zwitterionic Polymersmentioning

confidence: 99%

Zwitterionic ceramics for biomedical applications

2016

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“…Bare silica particles (bare SiP) and polyCMB (PCMB) brush-carrying silica particles (SiP-PCMB) reported previously [50] were also used in this study. Cholesteryl-2-bromoisobutyrate (Chol-BiB, Scheme 1a) and 1-O,3-O-dihexadecylglycerol (DHDG) were synthesized according to the literature [36,[51][52][53].…”

Section: Methodsmentioning

confidence: 99%

“…Such anti-aggregation behavior of Lipid-PCMB aggregates might be explained by the protective effect of hydrophilic and charge-neutralized PCMB chains [50]. Among the Lipid-PCMB conjugates examined, DHDG-PCMBs seemed to be more stably dispersed than Chol-PCMBs in salt solutions (Fig.…”

Section: Anti-aggregation Behavior In Salt Solution and Charge Distrimentioning

confidence: 97%

Self-association of zwitterionic polymer–lipid conjugates in water as examined by scattering measurements

Murou

Kitano

Fujita

et al. 2013

Journal of Colloid and Interface Science

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“…Although zwitterionic materials have proved to be also nonfouling (with values as low as 0.03 ng/cm 2 protein adsorption) [122,123], no zwitterionic brushes or layers were found for MSN or MSP coatings. Only SNP modified by ATRP with poly(carboxymethylbetaine) were found to be proposed as carrier for diagnosis, due to their self-assembling properties as colloidal crystals [124]. Other zwitterionic hybrid coatings with cellulose [125], SBA-15 [126] or PDA [127] but for flat surfaces were also found.…”

Section: Macromolecular Layersmentioning

confidence: 98%

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

Beltrán-Osuna

Perilla

2015

J Sol-Gel Sci Technol

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Continuous research in prominent fields such as biotechnology, biomedicine and nanopharmaceutics has brought the development of a widespread class of materials, and studies for mesoporous materials have been exponentially growing lately. The purpose of this review is to provide a useful guide for different materials, methods and configurations that have been reported in the last 5 years for the synthesis of spherical mesoporous silica particles (MSP), in the colloidal size range (1-1000 nm). MSP exhibit several limitations that must be overcome in order to enable their medical and clinical use. Surface modification of these particles will allow getting new promising characteristics of these materials, including better drug release control and biocompatibility improvement. These modified MSP could be potentially used in many biomedical applications, especially for drug delivery systems. Emphasis is made on the pore size, diameter and shape of the final particles since these parameters will establish key characteristics, i.e., drug delivery profile, loading capacity and efficiency. Graphical Abstract Spreading the use of mesoporous silica particles in biomedicine is possible by the improvement of its inner characteristics through surface modification. This may be done by chemical functionalization or by coating with macromolecular layers or brushes, thus creating novel responsive core-shell hybrid composites to be used as carriers for drug delivery applications.

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Silica particles coated with zwitterionic polymer brush: Formation of colloidal crystals and anti-biofouling properties in aqueous medium

Cited by 38 publications

References 36 publications

Zwitterionic ceramics for biomedical applications

Zwitterionic ceramics for biomedical applications

Self-association of zwitterionic polymer–lipid conjugates in water as examined by scattering measurements

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

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