Silicon micromachined hollow microneedles for transdermal liquid transport

Abstract

[999]Index Terms-Deep-reactive ion etching (DRIE), diagnostics, drug delivery, microneedle, point-of-care, transdermal.

Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

“…1) and the device can be attached to any standard luer tip or luer-lock syringe. The needles are 105 that is etched in a pattern to produce micropyramid-shaped microneedles, each having a very sharp tip that penetrates the epidermis followed by a conduit or through-channel for liquid delivery, and is produced using Micro Electro Mechanical System (MEMS) fabrication technology 106 in a semiconductor fabrication house. The microneedle chip is integrated with a plastic hub or female luer that attaches to any male luer tip or luer lock syringe, thereby enabling the delivery of liquid formulations from any standard (prefilled or disposable) syringe directly into the skin.…”

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

“…Different groups have investigated different types of microneedles, from in-plane [10] and out-ofplane [11], to hollow [12], solid [13], macroporous [14], dissolving and swelling [15]. They have been produced from a variety of materials such as glass [16], sugar [17], metal [18], metal coated [19], silicon [14], solid polymer [20], aqueous hydrogel [21] and dissolving polymers [15].…”

Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood

“…[19] Ito et al [13] have shown that plasma glucose level does not change significantly by reducing the 475 number of microneedles from 5 to 1 microneedle. Gardeniers et al [51] have demonstrated that plasma concentration of diclofenac increases by increasing the number of microneedles.…”