Silicone breast prostheses: A cohort study of complaints, complications, and explantations between 2003 and 2015

Pool, Shariselle M. W.; Wolthuizen, Roos; Mouës-Vink, Chantal M

doi:10.1016/j.bjps.2018.07.010

Cited by 36 publications

(20 citation statements)

References 21 publications

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“…Capsular contracture is the most frequent complication after breast augmentation and reconstruction with breast implants [ 3 , 4 , [9] , [10] , [11] , [13] , [14] , [15] , 17 ]. Although the etiology of CC is largely unknown [ 38 ], many authors have focused the attention on different risk factors such as immunological factors, bacterial contamination, and surgical technique [ [39] , [40] , [41] , [42] , [43] ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the etiology of CC is largely unknown [ 38 ], many authors have focused the attention on different risk factors such as immunological factors, bacterial contamination, and surgical technique [ [39] , [40] , [41] , [42] , [43] ]. Although none of the proposed theories are definitive, there is a consensus on the fact that breast reconstruction procedure, implants surface, and adjuvant PMRT represent additional causative factors [ 3 , 4 , [9] , [10] , [11] , 14 , 15 , [18] , [19] , [20] , 22 , 23 , 26 , 28 , 30 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Breast implants are employed since 1962, when Cronin and Gerow performed the first breast augmentation [ 1 ]. Since then, capsular contracture (CC) has represented the most common complication after breast implants insertion, and the leading cause for re-intervention [ [2] , [3] , [4] ]. Capsular contracture represents a normal reaction against the breast implant forming fibrous scar tissue around it, creating a tissue capsule [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immediate Breast Reconstruction after mastectomy with polyurethane implants versus textured implants: A retrospective study with focus on capsular contracture

et al. 2020

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Background: Capsular contracture (CC) is the most common complication following Immediate Breast Reconstruction (IBR) with breast implants. Different implant surfaces were developed aiming to reduce the incidence of CC. We evaluated the incidence and degree of CC after Direct-to-Implant (DTI) IBR with insertion of textured (TE) or polyurethane (PU) covered implants. Methods: A retrospective review of consecutive patients treated at our Institution with mastectomy and one-stage IBR and implant reconstruction between 2013 and 2018, with or without post mastectomy radiation therapy (PMRT), was conducted. Immediate breast reconstruction was performed by implanting 186 PU covered implants and 172 TE implants. Results: Three-hundred-twelve women underwent 358 DTI IBR with PU or TE implants, were analyzed with a median follow-up time of 2.3 years (range 1.0e3.0). The overall rate of CC Baker grade III and IV was 11.8% (95%CI: 8.4e16.3), while, after PU and TE implant placement it was 8.1% (95% CI: 4.1e15.7) and 15.8% (95% CI: 4.1e15.7) [p ¼ 0.009]), respectively. Irradiated breasts developed CC more frequently rather than non-irradiated breasts (HR ¼ 12.5, p < 0.001), and the relative risk was higher in the TE group compared with the PU group (HR ¼ 0.3, p ¼ 0.003). Conclusions: After mastectomy and one-stage IBR, the use of PU covered implants is associated with a lower incidence of CC compared to TE implants. This advantage is amplified several folds for patients who necessitate PMRT. Footnote: Capsular contracture (CC); Immediate Breast Reconstruction (IBR); Directto-Implant (DTI); Textured (TE); Polyurethane (PU); Post mastectomy radiation therapy (PMRT); Nipple Sparing mastectomy (NSM).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immediate Breast Reconstruction after mastectomy with polyurethane implants versus textured implants: A retrospective study with focus on capsular contracture

et al. 2020

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“…Rupture of silicone breast implants is an uncommon complication of breast implant surgery, with macroscopic leakage identified in 3% of explants. 17 Rupture of implants or injection of silicone materials allows for dispersion of silicone into the surrounding tissues and lymph nodes, inducing a foreign body reaction (Figure 3, G and H). In cases of ruptured implant, a fibrous capsule may form around the implant.…”

Section: Silicone Granulomamentioning

confidence: 99%

Cellular Spindled Histiocytic Pseudotumor: A Benign Mimic of Spindle Cell Neoplasia of the Breast

East

Carter

Sciallis

2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Cellular spindled histiocytic pseudotumor (CSHPT) is an exuberant, dense histiocytic proliferation seen in the setting of mammary fat necrosis. CSHPT has a broad histologic differential diagnosis, including benign, malignant, and inflammatory etiologies. Objectives.— To highlight the most important histologic and immunohistochemical findings of CSHPT and provide comparisons to entities within the broad differential diagnosis. Data Sources.— Recently published literature regarding CSHPT and other diagnostic considerations. Conclusions.— CSHPT is a benign histiocytic proliferation with a broad differential diagnosis, for which comprehensive ancillary studies may be required to exclude malignant and infectious entities.

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“…Capsular contracture (CC) remains a challenge in plastic surgery and represents one of the most common postoperative complications following alloplastic breast reconstruction or breast augmentation associated with revisional surgery and implant replacement [1,2]. Various theories exist on the aetiology of CC but the exact causes are still unknown [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Size matters—in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes

Tolksdorf

Horch

Grüner

et al. 2020

J Mater Sci: Mater Med

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Capsular contracture remains a challenge in plastic surgery and represents one of the most common postoperative complications following alloplastic breast reconstruction. The impact of the surface structure of silicone implants on the foreign body reaction and the behaviour of connective tissue-producing cells has already been discussed. The aim of this study was to investigate different pore sizes of silicone surfaces and their influence on human fibroblasts in an in vitro model. Four different textures (no, fine, medium and coarse texture) produced with the salt-loss technique, have been assessed in an in vitro model. Human fibroblasts were seeded onto silicone sheets and evaluated after 1, 4 and 7 days microscopically, with viability assay and gene expression analysis. Comparing the growth behaviour and adhesion of the fibroblasts on the four different textures, a dense cell layer, good adhesion and bridge-building ability of the cells could be observed for the fine and medium texture. Cell number and viability of the cells were increasing during the time course of experiments on every texture. TGFß1 was lowest expressed on the fine and medium texture indicating a trend for decreased fibrotic activity. For silicone surfaces produced with the salt-loss technique, we were able to show an antifibrotic effect of smaller sized pores. These findings underline the hypothesis of a key role of the implant surface and the pore size and pore structure in preventing capsular contracture.

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Silicone breast prostheses: A cohort study of complaints, complications, and explantations between 2003 and 2015

Cited by 36 publications

References 21 publications

Immediate Breast Reconstruction after mastectomy with polyurethane implants versus textured implants: A retrospective study with focus on capsular contracture

Immediate Breast Reconstruction after mastectomy with polyurethane implants versus textured implants: A retrospective study with focus on capsular contracture

Cellular Spindled Histiocytic Pseudotumor: A Benign Mimic of Spindle Cell Neoplasia of the Breast

Size matters—in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes

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