Silipide: A New Bioavailable Complex of Silybin

Pifferi, G.

doi:10.1055/s-2006-960251

Cited by 4 publications

(2 citation statements)

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“…These factors lead to low bioavailability of some phytomedicines. The formulation of phytosomes (achieved by 14 linking phytoconstituents to phosphatidylcholine) and herbosomes provide better absorbed dosage forms with better pharmacokinetic profiles [83,84].…”

Section: Large Molecular Sizementioning

confidence: 99%

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Oga¹,

Singh

2016

CPD

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Malaria is a potentially lethal disease caused by species of the plasmodium parasite. Despite the advances in the interventions for its control and approaches to manage fatality, morbidity and mortality rates associated with malaria are still high. At present, artemisinin-based combination therapy is the first line of treatment. However, there is the need to explore newer approaches as reduced effectiveness and multi-drug resistance (even to artemisinin) has been reported in some regions and is expected to widen in scope. Phytomedicines have shown promise for the management of this debilitating disease and there are abundant resources in most of the areas where this disease is endemic. This report would systematically review the literature, emphasizing the challenges encountered in the control of malaria, active phytochemicals currently utilised in the management, drug delivery approaches as well as the nanotechnology-based systems that could be exploited in its treatment. These phytomedicines, either delivered conventionally or via the use of advanced delivery systems may suggest new strategies towards the better management of malaria.

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Section: Large Molecular Sizementioning

confidence: 99%

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Oga¹,

Singh

2016

CPD

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show abstract

“…This rotational movement is then transmitted upward, allowing for the rotation of the upper part of helices of the channel (called S6 in Figure 11). 116 According to topological models, the N-and C-terminal domains of bestrophins would be located at the intracellular side of the membrane and would be connected to four or five hydrophobic TM4 TM4 TM5 TM5 TM3 TM6 TM6 TM3 TM7 TM7 TM2 TM2 domains forming the channel. As a result, the pore lumen opens and sodium and calcium ions enter the channel.…”

Section: Odorant Receptorsmentioning

confidence: 99%