Silk Fibroin-Based Scaffold for Bone Tissue Engineering

Choi, Joo Hee; Kim, Do Kyung; Song, Jeong Eun; Oliveira, Joaquím M.; Reis, Rui L.; Khang, Gilson

doi:10.1007/978-981-13-0947-2_20

Cited by 50 publications

(29 citation statements)

References 113 publications

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“…Silk fiber is a perfect blend of high strength, low weight, excellent durability, and elasticity (the strongest natural fiber). Silk is made up of two separate main proteins; one is silk fibroin (SF) made from the fibrous portion of the filament and another is sericin, which is a gluelike and water-soluble protein containing 18 different kinds of amino acids [62]. Studies have shown that, in addition to a tenable degradation rate and mechanical properties, the manufacturing of silk fibroin-based scaffolds of varying configurations yields attractive biocompatibility.…”

Section: Natural Biopolymer-based Scaffoldsmentioning

confidence: 99%

“…Silk fiber inclusion increases the compression strength in both in vivo and in vitro tests, minimizing setting time without adverse impact on injectability and cytocompatibility. Silk fibroin is one of the products that are favorable for bone tissue scaffolding applications due to its specific moderate mechanical properties, more controllable degradation rate than of many natural polymers, and high biological compatibility [62].…”

Section: Natural Biopolymer-based Scaffoldsmentioning

confidence: 99%

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A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

et al. 2021

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Tissue engineering (TE) and regenerative medicine integrate information and technology from various fields to restore/replace tissues and damaged organs for medical treatments. To achieve this, scaffolds act as delivery vectors or as cellular systems for drugs and cells; thereby, cellular material is able to colonize host cells sufficiently to meet up the requirements of regeneration and repair. This process is multi-stage and requires the development of various components to create the desired neo-tissue or organ. In several current TE strategies, biomaterials are essential components. While several polymers are established for their use as biomaterials, careful consideration of the cellular environment and interactions needed is required in selecting a polymer for a given application. Depending on this, scaffold materials can be of natural or synthetic origin, degradable or nondegradable. In this review, an overview of various natural and synthetic polymers and their possible composite scaffolds with their physicochemical properties including biocompatibility, biodegradability, morphology, mechanical strength, pore size, and porosity are discussed. The scaffolds fabrication techniques and a few commercially available biopolymers are also tabulated.

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Section: Natural Biopolymer-based Scaffoldsmentioning

confidence: 99%

Section: Natural Biopolymer-based Scaffoldsmentioning

confidence: 99%

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

et al. 2021

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“…It is the structural protein of silk fiber, characterized by high cytocompatibility, low immunogenicity, limited bacterial adhesion and outstanding mechanical properties able to support osteogenic differentiation. Moreover, its biodegradability can be tuned varying molecular weight, crystallinity, and β-sheet structure [39,45,51,52]. The silk fibroin versatility results evident from its several applications that range from the silk as bulk component to the silk as coating of non-cytocompatible scaffold or as reinforcing elements.…”

Section: Natural Polymersmentioning

confidence: 99%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.

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“…In addition to collagen, other natural biopolymers such as silk fibroin can also be effective in bone tissue engineering applications [ 79 , 80 ]. Silk fibroin is a fibrous protein produced by silkworms and spiders with outstanding mechanical characteristics, high biological compatibility, and an adjustable degradation rate that can support cell differentiation [ 81 , 82 ] and, thus, versatility in processing.…”

Section: Polymer Scaffolds For Gf Deliverymentioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

136

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Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

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Silk Fibroin-Based Scaffold for Bone Tissue Engineering

Cited by 50 publications

References 113 publications

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Advances in Growth Factor Delivery for Bone Tissue Engineering

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