Silver acetate coating promotes early vascularization of Dacron vascular grafts without inducing host tissue inflammation

Jeanmonod, Pascal; Laschke, Matthias W.; Gola, Nils; Heesen, Maximilian von; Glanemann, Matthias; Dold, Stefan; Menger, Michael D.; Moussavian, M. R.

doi:10.1016/j.jvs.2013.02.012

Cited by 21 publications

(17 citation statements)

References 28 publications

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“…In their report, Tautenhahn et al demonstrated that silver-coated vascular polyester grafts highly activate human neutrophils when compared with regular polyester grafts, causing the neutrophil to release high levels of elastase (a very destructive enzyme) in the absence of a bacterial trigger. 10 On the contrary, Jeanmonod et al 11 provide evidence in vivo that silver acetate (used in the Maquet graft), does not induce a leukocyte-mediated tissue inflammatory response, but in fact stimulates ingrowth of microvessels, promoting implant incorporation.…”

Section: Discussionmentioning

confidence: 99%

Localized Argyria Caused by Metallic Silver Aortic Grafts: A Unique Adverse Effect

Berger

Ricco

Lung

et al. 2013

European Journal of Vascular and Endovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Localized Argyria Caused by Metallic Silver Aortic Grafts: A Unique Adverse Effect

Berger

Ricco

Lung

et al. 2013

European Journal of Vascular and Endovascular Surgery

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“…whereas the investigation of potential functions of silver in bone regeneration is a quite recent occurrence [239]. Analysis of the tissue response to silver acetate coated Dacron vascular grafts implanted into the dorsal skinfold chamber in mice revealed higher functional capillary density without affecting inflammatory host tissue response, collagen formation, apoptosis and cell proliferation as compared to uncoated grafts [240]. Furthermore, functionalization of silver nanoparticles in tissue regeneration has already been introduced into commercially available wound dressings, as the exhibit outstanding anti-microbial and anti-inflammatory properties [241][242][243].…”

Section: Silver (Ag + )mentioning

confidence: 99%

Applications of Metals for Bone Regeneration

Glenske¹,

Donkiewicz²,

Köwitsch³

et al. 2018

Preprint

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The regeneration of bone tissue is a main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, while it should be resorbed even in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated and it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also on osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between the formation of new bone tissue and material degradation has not been found until now. The addition of different substances such as collagen or growth factors and also of different cell types have already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are differently used as basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designated for bone regeneration with the aim to give an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.

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“…Silver acetate-coated polyester grafts rapidly release substantial amounts of silver into the surrounding tissue in the interval of 2-3 weeks after implantation. Vaporized metallic silver-coated polyester graft releases marginal amounts of silver in the perigraft tissue during the fi rst 12 months after implantation (55,56). The advantage of silver acetate-coated grafts in comparison with the second type of grafts lies in better perigraft vascularization and reduced perigraft infl ammation during the fi rst 14 days after implantation and it should be the reason of lower reinfection rate.…”

Section: Treatment Optionsmentioning

confidence: 99%

Management of aortic graft infections – the present strategy and future perspectives

Treska¹,

Certík²,

Moláček³

2016

BLL

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Aortic graft infections (AGI) are serious complications of open and endovascular types of surgery with an incidence rate of 0.6-3 %. AGI are associated with 30-60 % perioperative mortality and 40-60 % morbidity rate with limb amputation rates between 10 % and 40 %. The economic cost of AGI is substantial. At the time of aortic reconstruction, almost 90 % of patients have one or more predisposing factors for AGI. The diagnosis is based on clinical symptomatology, laboratory markers, microbial cultures, and imaging modalities. The general principle of surgical treatment lies in the removal of infected graft, debridement of infected periprosthetic tissues, and vascular reconstruction by in situ or extra-anatomic bypass with long-term antibiotic therapy. The conservative treatment is used only for selected patients with endograft infection. This review summarizes the current knowledge about the incidence, predisposing factors, etiology, diagnosis, treatment options, and prevention of aortic vascular graft and endograft infections. With the growing number of endovascular procedures we can expect more cases of infected aortic endografts in patients with severe comorbidities in the near future, where the recent radical surgical approach (graft excision, debridement, and new revascularization) cannot be used. Therefore the less invasive, sophisticated and individualized treatment strategies will have to be used in search of the best therapeutic approach to each specifi c patient (Fig. 4, Ref. 82). Text in PDF www.elis.sk.

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Silver acetate coating promotes early vascularization of Dacron vascular grafts without inducing host tissue inflammation

Cited by 21 publications

References 28 publications

Localized Argyria Caused by Metallic Silver Aortic Grafts: A Unique Adverse Effect

Localized Argyria Caused by Metallic Silver Aortic Grafts: A Unique Adverse Effect

Applications of Metals for Bone Regeneration

Management of aortic graft infections – the present strategy and future perspectives

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