Silver and gold nanoparticles: Potential cancer theranostic applications, recent development, challenges, and future perspectives

Londhe, Swapnali; Haque, Shagufta; Patra, Chitta Ranjan

doi:10.1016/b978-0-323-99454-5.00006-8

Cited by 11 publications

(9 citation statements)

References 168 publications

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“…Recently, nanotechnology is emerging as a promising technology in several biomedical sectors for the treatment of various diseases such as cardiovascular diseases, wound healing, neurodegenerative diseases, microbial infections including cancer [72,73]. Among various nanomaterials, transition metal nanoformulations have been extensively used for cancer therapy because of their unique physiochemical properties [72,[74][75][76][77][78][79][80] These metal-based nanoformulations are advantageous over the conventionally treated anti-cancer drugs because of their site specific targeting, controlled release and less side effects. To this, scientists are focusing on the design, development and fabrication of economic, biocompatible, stable, ecofriendly nitroprusside-based metal nanocomplexes for the delivery of NO, metal ions or drugs in to the tumor microenvironment [10][11][12][13].…”

Section: Nitroprusside Based Nanomaterialsmentioning

confidence: 99%

“…The majority of conventionally prepared silver nanoparticles exhibit several drawbacks such as photobleaching, stability, increased concentration of Ag + , non specific targeting etc. that limits their therapeutic efficacy [76]. To this, Londhe et al designed and synthesized silver nitroprusside nanoparticles (AgNNPs) by the interaction between silver nitrate and FDA approved SNP as well as explored the anticancer activity in breast carcinoma [10].…”

Section: Silver Nitroprussidementioning

confidence: 99%

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Nitroprusside and metal nitroprusside nano analogues for cancer therapy

Tripathy,

Londhe,

Patra

2024

Biomed. Mater.

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Sodium nitroprusside (SNP), U.S approved drug has been used in clinical emergency as a hypertensive drug for more than a decade. It is well established for its various biomedical applications such as angiogenesis, wound healing, neurological disorders including anti-microbial applications etc. Apart from that, SNP have been considered as excellent biomedical materials for its use as anti-cancer agent because of its behavior as NO-donor. Recent reports suggest that incorporation of metals in SNP/encapsulation of SNP in metal nanoparticles (metal nitroprusside analogues) shows better therapeutic anti-cancer activity. Although there are numerous reports available regarding the biological applications of SNP and metal-based SNP analogue nanoparticles, unfortunately there is not a single comprehensive review which highlights the anti-cancer activity of SNP and its derivative metal analogues in detail along with the future perspective. To this end, the present review article focuses the recent development of anti-cancer activity of SNP and metal-based SNP analogues, their plausible mechanism of action, current status. Furthermore, the future perspectives and challenges of these biomedical materials are also discussed. Overall, this review article represents a new perspective in the area of cancer nanomedicine that will attract a wider spectrum of scientific community.

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Section: Nitroprusside Based Nanomaterialsmentioning

confidence: 99%

Section: Silver Nitroprussidementioning

confidence: 99%

Nitroprusside and metal nitroprusside nano analogues for cancer therapy

Tripathy,

Londhe,

Patra

2024

Biomed. Mater.

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“… 122 , 219 Furthermore, they can be used in a variety of scenarios, including cancer therapy, wound healing, biosensing, tissue engineering, and diagnostics. 220 , 221 …”

Section: Advantages Of Biomedical Applications Of Green Synthesized A...mentioning

confidence: 99%

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

Ahmad,

Ali

et al. 2024

IJN

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Green synthesis of silver (Ag) and gold (Au) nanoparticles (NPs) has acquired huge popularity owing to their potential applications in various fields. A large number of research articles exist in the literature describing the green synthesis of Ag and Au NPs for biomedical applications. However, these findings are scattered, making it time-consuming for researchers to locate promising advancements in Ag and Au NPs synthesis and their unexplored biomedical applications. Unlike other review articles, this systematic study not only highlights recent advancements in the green synthesis of Ag and Au NPs but also explores their potential unexplored biomedical applications. The article discusses the various synthesis approaches for the green synthesis of Ag and Au NPs highlighting the emerging developments and novel strategies. Then, the article reviews the important biomedical applications of green synthesized Ag and Au NPs by critically evaluating the expected advantages. To expose future research direction in the field, the article describes the unexplored biomedical applications of the NPs. Finally, the articles discuss the challenges and limitations in the green synthesis of Ag and Au NPs and their biomedical applications. This article will serve as a valuable reference for researchers, working on green synthesis of Ag and Au NPs for biomedical applications.

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“…[43][44][45] In addition, nanoparticles are employed in cancer theranostics, an approach where anticancer and imaging agents are combined in a single system. [46][47][48] In this review, conventional and emerging therapies for retinoblastoma were discussed, with an emphasis on the recent developments, challenges and prospects of the use of nanoparticles as novel delivery systems for chemotherapeutic drugs and imaging agents. The potential use of nanoparticles in active drug targeting and in the delivery of phytochemicals to the retinoblastoma cells was also discussed.…”

Section: Nanoscale Advances Reviewmentioning

confidence: 99%

“…43–45 In addition, nanoparticles are employed in cancer theranostics, an approach where anticancer and imaging agents are combined in a single system. 46–48…”

Section: Introductionmentioning

confidence: 99%