Silver Based Materials for Biomedical Applications

Nedelcu, Ioan-Avram; Ficai, Anton; Sönmez, Maria; Ficai, Denisa; Oprea, Ovidiu; Andronescu, Ecaterina

doi:10.2174/13852728113176660141

Cited by 48 publications

(31 citation statements)

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“…The mechanism of action of nanoparticles is very important and differ depending on the nature and characteristics of nanoparticles [11,13,31,[98][99][100][101][102][103][104]. In the case of silver nanoparticles, the antimicrobial and anti-fungal activity is mainly assured by the produced Reactive Oxygen Species (ROS) which are altering the normal, intracellular functions of these micro-organisms while, most of the metal oxides (ZnO, MgO and CaO) are inducing a cellular wall destruction and consequently these microorganisms are losing their integrity.…”

Section: Green Synthesis Of Silver Nanomaterialsmentioning

confidence: 99%

“…Such metal oxides are TiO2 and ZnO. These nanoparticles are effective in aqueous suspension but also many applications are known where these nanoparticles are dispersed into the bulk materials or deposited onto various surfaces [102,[105][106][107]. The properties can be designed also by developing heterogeneous core@shell structures as 1D (particles), usually dispersed in aqueous suspension or deposited as 2D…”

Section: Green Synthesis Of Silver Nanomaterialsmentioning

confidence: 99%

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Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Craciun³

et al. 2020

Preprint

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This paper aims to review the challenges, toxicity, and routes of synthesis and usage of silver nanoparticles in different medical applications but also highlighting their sustainability from both medical and environmental issues. Regarding their toxicity, it is known that silver nanoparticles can destroy over 650 microorganisms comparing with antibiotics. Supplementary, will be presented in a comparative manner some conventional synthesis routes (physical and chemical methods) and green synthesis routes using plant extracts. The approach using plant extracts have various advantages comparing with physical, chemical and microbial synthesis methods because there is no need to use chemicals, wasteful purifications and high energy requirements. The main focus in “green nanotechnology” was to use either biological micro-organisms or plant extracts which are an alternative to the classical chemical and physical methods. An important issue that is discussed in the paper is the potential toxicity of silver nanoparticles that may have on human health or on the environment, which powerfully indicates that, the usage and removal of silver nanoparticles must be carefully examined. Also, it needs to focus our attention on the dismissal of silver nanoparticles into the environment and especially in water systems, fact which suggests that this issue must be fully understood and apply accordingly the law.

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Section: Green Synthesis Of Silver Nanomaterialsmentioning

confidence: 99%

Section: Green Synthesis Of Silver Nanomaterialsmentioning

confidence: 99%

Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Craciun³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metal nanoparticles, such as silver and gold with the size of 1−100 nm, possess different chemical, physical, and optical properties compared to those of their bulk structures while due to relatively high surface areas could exhibit various properties and applications in diverse elds [17]. In particular, silver nanoparticles (AgNPs) have attracted impressive attention toward the biomedicinerelated assessment as unconventional antimicrobial agents [18][19][20]. Conjugation of drugs onto silver nanoparticles can protect them against the body's immune system, thereby extending their blood circulation time [21].…”

Section: Introductionmentioning

confidence: 99%

First Principle Study of Silver Nanoparticles Interactions with Antimalarial Drugs Extracted from Artemisia Annua Plant

Akbari

Morad

Mâaza

2020

Preprint

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Silver nanoparticles have a great potential in a broad range of applications such as drug-delivery carriers because of their antiviral and antibacterial properties. In this study, the coating properties of silver nanoparticle with three common anti-malarial drugs Artemisinin, Artemether, and Artesunate have been studied by using the quantum mechanical and classical atomistic molecular dynamics simulation in order to use as the drug delivery to treat Malaria and COVID-19 diseases. The optimized structure, frequencies, charge distribution and the electrostatic potential maps of three drug molecules were simulated by using the density functional theory (DFT) at the B3LYP/6-311++g(d,p) level of theory. Then molecular dynamics simulation was used to study the coating of AgNP with each of these drugs. The affinity of interaction was obtained as; Artesunate > Artemether > Artemisinin which is in agreement with the DFT results on the adsorption of drugs on the Ag(111) slab.

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“…The mechanism of action of nanoparticles is very important and differ depending on the nature and characteristics of nanoparticles [11,13,33,[100][101][102][103][104][105][106]. In the case of silver nanoparticles, the antimicrobial and anti-fungal activity is mainly assured by the produced Reactive Oxygen Species (ROS) which are altering the normal, intracellular functions of these micro-organisms while, most of the metal oxides (ZnO, MgO and CaO) are inducing a cellular wall destruction and consequently these microorganisms are losing their integrity.…”

mentioning

confidence: 99%

“…Such metal oxides are TiO2 and ZnO. These nanoparticles are effective in aqueous suspension but also many applications are known where these nanoparticles are dispersed into the bulk materials or deposited onto various surfaces [104,[107][108][109]. The properties can be designed also by developing heterogeneous core@shell structures as 1D (particles), usually dispersed in aqueous suspension or deposited as 2D antimicrobial coating (film) [110,111].…”

mentioning

confidence: 99%

Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Ficai³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

This paper aims to review the challenges, toxicity, and routes of synthesis and usage of silver nanoparticles in different applications but also highlighting their sustainability from both medical and environmental issues. Regarding their toxicity, it is known that silver nanoparticles can destroy over 650 microorganisms comparing with antibiotics. Supplementary, will be presented in a comparative manner some conventional synthesis routes (physical and chemical methods) and green synthesis routes using plant extracts. The approach using plant extracts have various advantages comparing with physical, chemical and microbial synthesis methods because there is no need to use chemicals, wasteful purifications and high energy requirements. The paper presents an overview on “green nanotechnology” focused on using either biological micro-organisms or plant extracts as an alternative to the classical chemical and physical methods. An important issue discussed in the paper is an overview of the synthesis routes of silver nanoparticles, some expected applications of silver based active agents and their toxicity and challenges that must be overcome. Also, it needs to focus our attention on the dismissal of silver nanoparticles into the environment and especially in water systems, fact which suggests that this issue must be fully understood and applied the law.

show abstract

Silver Based Materials for Biomedical Applications

Cited by 48 publications

References 0 publications

Toward Synthesis-derived Applications of Silver Nanoparticles

Toward Synthesis-derived Applications of Silver Nanoparticles

First Principle Study of Silver Nanoparticles Interactions with Antimalarial Drugs Extracted from Artemisia Annua Plant

Toward Synthesis-derived Applications of Silver Nanoparticles

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