Silver-Coated Dressing Acticoat Caused Raised Liver Enzymes and Argyria-like Symptoms in Burn Patient

Trop, Marija; Novák, Michael; Rödl, Siegfried; Hellbom, B.; Kroell, Wolfgang; Goessler, Walter

doi:10.1097/01.ta.0000208126.22089.b6

Cited by 305 publications

(214 citation statements)

References 22 publications

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“…Furthermore, increased liver enzymes were reported in Sprague-Dawley rats after Twenty-eight-day oral exposure to nano-silver particles (60 nm) . It was reported that silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patients (Trop et al 2006). The in vitro and in vivo studies revealed toxicity effects of silver nanoparticles on immune system, especially cytokine excretion.…”

Section: Toxicity Of Nano-silver Particlesmentioning

confidence: 99%

Silver Nanoparticles

Korbekandi¹,

Iravani²

2012

The Delivery of Nanoparticles

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Section: Toxicity Of Nano-silver Particlesmentioning

confidence: 99%

Silver Nanoparticles

Korbekandi¹,

Iravani²

2012

The Delivery of Nanoparticles

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“…However, very recently Verano-Braga et al (2014) reported that the toxicity of AgNPs depends upon both dosage and particle size. Metal nanoparticles show large surface to volume ratio and exhibit antimicrobial properties due to their ability to interact with cellular membranes through disruption of cell wall structure (Ahmad et al 2013;Trop et al 2006). Especially silver has long been known for its strong toxicity against a wide range of micro organisms including bacteria and fungi (Narayanan and Park 2014).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of silver nanoparticles from Aloe vera leaf extract and antifungal activity against Rhizopus sp. and Aspergillus sp.

et al. 2014

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Silver nanoparticles are receiving increasing attention in the field of agriculture. This study aims at evaluating the antifungal properties of green synthesised silver nanoparticles (AgNPs) from Aloe vera leaf extract against two pathogenic fungus Rhizopus sp. and Aspergillus sp. Results revealed that synthesised nanoparticles showed strong absorption maximum at 400 nm corresponding to the surface plasmon resonance. The prepared nanoparticles were characterized by SEM, FT-IR and UVVis spectroscopy. From the scanning photograph it is clear that particles are heterogeneous in shape such as rectangular, triangular and spherical with uniform distribution. FT-IR study showed sharp absorption peaks at 1,631 and 3,433 cm -1 for amide and alcoholic hydroxide groups, respectively. On the other hand, synthesised silver nanoparticles showed highest antifungal activity against Aspergillus sp. than Rhizopus sp. by application of 100 lL of 1 M silver nanoparticles with maximum inhibition of the growth of fungal hyphae. However, microscopic observation revealed that synthesised nanoparticles caused detrimental effects on conidial germination along with other deformations such as structure of cell membrane and inhibited normal budding process of both the tested species. Therefore, it has been concluded that Aloe vera leaf extract origin silver nanoparticles have tremendous potentiality towards controlling pathogenic fungus. However, further research is needed to check the efficacy of sizedependent AgNPs on different species of fungus.

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“…Thus far a single case report has been published that describes a case of argyria occurring in a patient with 30% burns treated with a silver-coated wound dressing. 31 Our patient's leukopenia was attributed to the elevated silver levels resulting from the use of the silverimpregnated sponge. Initially it was thought that the patient might have a transient leukopenia from underlying sepsis and malignancy.…”

Section: Discussionmentioning

confidence: 99%

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

LaRiviere

Goldin

Avansino

2011

The Journal of the American College of Certified Wound Speciali

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Silver-containing topical agents are used to help prevent infectious complications in wound therapy. Toxicity from topical silver agent exposure was initially reported in 1975 and was clinically characterized by granulocytopenia. Currently, the data regarding potential toxicity associated with silver-impregnated devices are limited. A 23-year-old patient receiving chemotherapy for acute lymphoblastic leukemia presented with necrotizing fasciitis of the abdominal wall and scrotum from a Crohn disease-related psoas-enteric fistula. Surgical debridement of the soft-tissue and abdominal musculature was performed to the peritoneum. Silver-containing foam sponges and wound vacuumassisted closure were applied directly to the peritoneum 2 weeks after initial debridement. Subsequently, the patient developed leukopenia, and workup revealed the serum silver level was 4 times normal level. Silver-impregnated sponges were discontinued and silver-free sponges and wound vacuum-assisted closure therapy resumed, followed by leukopenia resolution. Silver toxicity associated with routine application of silver-impregnated sponges has not been previously reported.

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Silver-Coated Dressing Acticoat Caused Raised Liver Enzymes and Argyria-like Symptoms in Burn Patient

Cited by 305 publications

References 22 publications

Silver Nanoparticles

Silver Nanoparticles

Biosynthesis of silver nanoparticles from Aloe vera leaf extract and antifungal activity against Rhizopus sp. and Aspergillus sp.

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

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