Silver Compounds for Caries Management

Xu, Grace Y.; Zhao, Irene S.; Lung, Christie Y.K.; Yin, Iris X.; Lo, Edward C.M.; Chu, Chun Hung

doi:10.1016/j.identj.2023.10.013

International Dental Journal

2024

DOI: 10.1016/j.identj.2023.10.013

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Silver Compounds for Caries Management

Grace Y. Xu,

Irene S. Zhao,

Christie Y.K. Lung

et al.

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2024

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Cited by 8 publications

(2 citation statements)

References 70 publications

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“…Silbernitrat (AgNO 3 ) war die erste auf dem Dentalmarkt verfügbare Substanz zur Kariesbehandlung. Es wurde zur Reduktion der Kariesentstehung im Milchgebiss verwendet und später dann auch zum Kariesschutz an bleibenden Seitenzähnen, zur Kavitätendesinfektion und als Desensitizer[7,8]. Anfang des 20.…”

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“…Daher gab es Bestrebungen, die Kombination von Silber und Fluorid zur Kariesbehandlung weiterzuentwickeln, unter der Annahme einer kombinierten positiven Wirkung der Einzelkomponenten. Die heute unter den Silberfluoridpräparaten am weitesten verbreitete Substanzdas Silberdiaminfluorid [Ag(NH 3 ) 2 F] geht auf Entwicklungen in Japan Ende der 1970er Jahre zurück[7]. Es ist bereits seit längerer Zeit in mehreren Ländern, unter anderem Japan, China, Australien, Argentinien und Brasilien, für verschiedene Indikationen etabliert.…”

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Silberdiaminfluorid zum Kariesmanagement

Göstemeyer,

Bombeck,

Schlieker

2024

Zahnmedizin up2date

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Silberdiaminfluorid zum Kariesmanagement

Göstemeyer,

Bombeck,

Schlieker

2024

Zahnmedizin up2date

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Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna,

Donovan,

McKee

et al. 2024

The Journal of Prosthetic Dentistry

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Efficacy of silver diamine fluoride (SDF) in arresting dentin caries against inter-kingdom biofilms of Streptococcus mutans and Candida albicans

Kaewkamchai,

Thanyasrisung,

Sukarawan

et al. 2024

PLoS ONE

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Objectives To compare, in vitro, the efficacy of three proprietary silver diamine fluoride (SDF) products in mitigating progression of dentinal caries induced by an inter-kingdom, dual-species, bacterial-yeast biofilm. Methods Human dentin blocks were demineralized to create artificial caries lesions and randomized into three SDF test groups: Saforide, Topamine, T-SDF, and an aqueous control (n = 26 per group). After application of foregoing SDF variants, the blocks were incubated with Streptococcus mutans and Candida albicans for 24 h for biofilm development, and subsequently subjected to a microbe-induced, pH-cycling process for 7 days, to mimic the oral eco-system. The biofilm cell viability and surface topography were assessed by colony-forming units (CFUs) and scanning electron microscopy respectively. The lesion depth and mineral density were evaluated by micro-computer tomography. SDF precipitate and matrix-to-mineral ratio were evaluated by X-ray diffraction and Fourier transform infrared spectroscopy, respectively. Standard, accepted methodology was used for all these evaluations and procedures. Results After pH cycling, the SDF groups demonstrated comparable inhibition of the biofilm relative to the control. the log CFU of S. mutans for Saforide, Topamine, T-SDF, and control were 6.69±0.73, 6.48±0.56, 6.63±0.66, and 8.01±0.45, respectively. For C. albicans, the log CFU were 4.86±0.44, 4.72±0.53, 4.92±0.29, and 5.60±0.27, respectively. The log CFU of S. mutans and C. albicans in the SDF groups were significantly lower than the control group (p<0.001). Further, the lesion depth decreased by approximately 14.79±7.00% in the SDF groups, while it increased by 11.07±8.61% in the control (p<0.001), and the mineral density increased by 16.36±4.58% in the SDF group, as opposed to a 5.59±2.64% reduction in the control (p<0.001) implying their caries mitigating effect. These findings were corroborated by SEM images of the lesions. Conclusion SDF significantly mitigated dentin caries due to an assault by a polymicrobial plaque biofilm whilst arresting mineral loss and lesion growth. There was no difference in the caries-arresting efficacy of the compared SDF variants.

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Silver Compounds for Caries Management

Cited by 8 publications

References 70 publications

Silberdiaminfluorid zum Kariesmanagement

Silberdiaminfluorid zum Kariesmanagement

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Efficacy of silver diamine fluoride (SDF) in arresting dentin caries against inter-kingdom biofilms of Streptococcus mutans and Candida albicans

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