Silver nano — A trove for retinal therapies

Kalishwaralal, Kalimuthu; BarathManiKanth, Selvaraj; Pandian, Sureshbabu Ram Kumar; Deepak, V.; Gurunathan, Sangiliyandi

doi:10.1016/j.jconrel.2010.03.022

Cited by 107 publications

(72 citation statements)

References 98 publications

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“…Selenuim is an antioxidant that stimulates the immune system and contributes to the formation of antibodies against infectious agents. Nickel activates some enzyme systems in the body [13]. The presence of these minerals reinforces the medicinal potentials of these study plants.…”

Section: Resultssupporting

confidence: 60%

Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Renuga¹

2018

IJRASET

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This rapidly developing field of nanoscience has raised the possibility of using therapeutic nanoparticles in the diagnosis and treatment of human cancers. The research demonstrates the efficiency of artemisinin is a sesquiterpene lactone isolated from the leaves of Artemisia pallens by using classical biochemical techniques and the purified molecules analyzed by HPLC. The artemisinin concentration has been reported to be higher at the top of the leaves Artemisia pallens plants, shown to be effective against Dalton's lymphoma ascites (DLA) cancer. Carboplatin, a platinum-containing anticancer drug treatment caused a significant increase in the life span of ascites Dalton's lymphoma tumor bearing mice. However, as compared to carboplatin, artemisinin and combination treatment with artemisinin plus carboplatin resulted in better therapeutic efficacy against Dalton's lymphoma tumor. Artemisinin loaded silver nanoparticles were administrated to ascites Dalton's lymphoma tumor induced mice 100µg/kg/day IP injection for 15 days at two days intervals, the antitumor efficiency of AgNPs significantly increased the survival time in the tumor mouse model in comparison with tumor controls also decreased the volume of ascitic fluid in tumor-bearing mice by 75%, thereby returning body weight closer to normal animals. Artemisinin may be especially effective in treating drug resistant cancers. These findings confirm the antitumor properties of AgNPs, and suggest that bioactive substance Artemisinin may be a cost-effective alternative in the treatment of cancer.

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Section: Resultssupporting

confidence: 60%

Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Renuga¹

2018

IJRASET

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“…40 Several studies have reported the use of AgNPs as anticancer 41 and antiangiogenic agents in retinal endothelial cells. AgNPs showed significant toxicity in various human cell lines such as human lung fibroblast cells (IMR-90) and human glioblastoma cells (U251), 42 endothelial cells, 43 and MDA-MB-231 human breast cancer cells. 44 However, Ag and graphene as individual agents both show weaker biological activity than graphene-silver nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy

Gurunathan¹,

Han²,

Park³

et al. 2015

IJN

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233

218

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Background Graphene and graphene-based nanocomposites are used in various research areas including sensing, energy storage, and catalysis. The mechanical, thermal, electrical, and biological properties render graphene-based nanocomposites of metallic nanoparticles useful for several biomedical applications. Epithelial ovarian carcinoma is the fifth most deadly cancer in women; most tumors initially respond to chemotherapy, but eventually acquire chemoresistance. Consequently, the development of novel molecules for cancer therapy is essential. This study was designed to develop a simple, non-toxic, environmentally friendly method for the synthesis of reduced graphene oxide–silver (rGO–Ag) nanoparticle nanocomposites using Tilia amurensis plant extracts as reducing and stabilizing agents. The anticancer properties of rGO–Ag were evaluated in ovarian cancer cells. Methods The synthesized rGO–Ag nanocomposite was characterized using various analytical techniques. The anticancer properties of the rGO–Ag nanocomposite were evaluated using a series of assays such as cell viability, lactate dehydrogenase leakage, reactive oxygen species generation, cellular levels of malonaldehyde and glutathione, caspase-3 activity, and DNA fragmentation in ovarian cancer cells (A2780). Results AgNPs with an average size of 20 nm were uniformly dispersed on graphene sheets. The data obtained from the biochemical assays indicate that the rGO–Ag nanocomposite significantly inhibited cell viability in A2780 ovarian cancer cells and increased lactate dehydrogenase leakage, reactive oxygen species generation, caspase-3 activity, and DNA fragmentation compared with other tested nanomaterials such as graphene oxide, rGO, and AgNPs. Conclusion T. amurensis plant extract-mediated rGO–Ag nanocomposites could facilitate the large-scale production of graphene-based nanocomposites; rGO–Ag showed a significant inhibiting effect on cell viability compared to graphene oxide, rGO, and silver nanoparticles. The nanocomposites could be effective non-toxic therapeutic agents for the treatment of both cancer and cancer stem cells.

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“…One of the most commonly used nanoparticles is silver nanoparticles (AgNPs) which have been applied to clothing, food industry, paints, and electronics [2][3][4][5][6]. Also, AgNPs used in medical applications as the constituent elements of catheters, implant surfaces, dental alloys and for treating wounds and burns-related infections as well as in drug delivery in cancer therapies [7][8][9][10]. Such an increasingly widespread usage of AgNPs leads to the exposure of humans, animals and plants through industrial or domestic waste which could produce harmful biological response [11].…”

Section: Introductionmentioning

confidence: 99%

Toxicogenomic Analysis for Livers from Sprague-Daley Rats Following 12-Week Inhalation Exposure to Silver Nanoparticles

2016

JNMR

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Silver nanoparticles (AgNPs) have been extensively applied to many industrial and biomedical fields due to their antibacterial effect. However, a large number of applications is also lead to health and environmental safety concerns. Up to date, it was well-known that AgNPs induced reactive oxygen species (ROS) production, cytotoxicity, pro-inflammatory effect, DNA damage, cell cycle disturb, necrosis and apoptosis by many researches. Also, several studies have been performed to investigate the microarray test for AgNPs in many cell types. However, no work reports the AgNPs toxicogenomic study in liver cell line and tissue until now. For this reason, we performed to in vivo toxicogenomic study for AgNPs inhalation exposed liver tissue. After 12 weeks inhalation exposure to AgNPs for the Sprague-Daley rats, we carried out silver concentration measurement for liver tissues and toxicogenomic analysis. As a result, we found that silver concentrations in livers were dose-dependently increased in male and female rats. However, a gender-different accumulation of silver in the livers did not observe. In toxicogenomic study, we observed that 109 and 150 genes significantly up-and down regulated by AgNPs inhalation exposure in male and female rats, respectively. The significantly altered male rat genes were involved in 54 biological pathways which were typically related with diabetes and metabolism. In female rat, the significantly expression changed genes were involved in 89 biological pathways which were mainly connected with metabolism and cell signaling. Plus, the gender-dependent gene expression changes of more than 2 fold were linked to 240 genes, with 114 genes in the male livers and 126 genes in the female livers. These were related to steroids and xenobiotics metabolism pathway.

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Silver nano — A trove for retinal therapies

Cited by 107 publications

References 98 publications

Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy

Toxicogenomic Analysis for Livers from Sprague-Daley Rats Following 12-Week Inhalation Exposure to Silver Nanoparticles

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Silver nano — A trove for retinal therapies

Cited by 107 publications

References 98 publications

Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Pharmaceutical Efficacy of Artemisinin from Artemisia Pallens with Reference to Antitumor Potential

Reduced graphene oxide&ndash;silver nanoparticle nanocomposite: a potential anticancer nanotherapy

Toxicogenomic Analysis for Livers from Sprague-Daley Rats Following 12-Week Inhalation Exposure to Silver Nanoparticles

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Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy