Silver Nanomaterials for Wound Dressing Applications

Abstract

Silver nanoparticles (AgNPs) have recently become very attractive for the scientific community due to their broad spectrum of applications in the biomedical field. The main advantages of AgNPs include a simple method of synthesis, a simple way to change their morphology and high surface area to volume ratio. Much research has been carried out over the years to evaluate their possible effectivity against microbial organisms. The most important factors which influence the effectivity of AgNPs against microorganisms are the method of their preparation and the type of application. When incorporated into fabric wound dressings and other textiles, AgNPs have shown significant antibacterial activity against both Gram-positive and Gram-negative bacteria and inhibited biofilm formation. In this review, the different routes of synthesizing AgNPs with controlled size and geometry including chemical, green, irradiation and thermal synthesis, as well as the different types of application of AgNPs for wound dressings such as membrane immobilization, topical application, preparation of nanofibers and hydrogels, and the mechanism behind their antimicrobial activity, have been discussed elaborately.

New Protein-Coated Silver Nanoparticles: Characterization, Antitumor and Amoebicidal Activity, Antiproliferative Selectivity, Genotoxicity, and Biocompatibility Evaluation

“…The versatility of AgNPs in the biomedical field has been demonstrated and discussed in several recent reviews [ 6 , 41 , 42 , 43 ]. Their antimicrobial, antiviral, antiparasitic, and antiproliferative activity relies on physicochemical properties such as size, surface charge, and coating agent [ 39 , 44 , 45 , 46 , 47 ].…”

Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

“…Nanoparticles can be used in several areas, such as in tissue engineering, in the pharmaceutical, aerospace, and microelectronics industries, in production, processing, protection, and packaging of food, among others. For example, silver nanoparticles have been increasingly explored in this area due to their peculiar physical, chemical, and optical properties [6]. Silver nanoparticles (AgNPs) have intrinsic antibacterial and anticancer properties, through several mechanisms, like for example, due to silver ions or formation of radical species, released and formed respectively after the AgNPs are up took by the living cells or bacteria, which originates deregulation of important cellular mechanisms, leading to aggravated cellular damage and death.…”

State-of-the-Art of Eggshell Waste in Materials Science: Recent Advances in Catalysis, Pharmaceutical Applications, and Mechanochemistry

“…ESM was used as an integral component of various formulations, to enhance wound healing, facilitate rapid endothelialization and anticoagulation (Yan et al, 2020a ). It was suggested as an important component of various wound-care dressings (Guarderas et al, 2016 ; Kiselioviene et al, 2016 ; Li et al, 2016 , 2019b , c ; Krishnan et al, 2020 ). ESM was also used to produce hybrid nanofibrous scaffolds for cutaneous tissue engineering (Mohammadzadeh et al, 2019 ), materials for periodontal tissues (Motoji et al, 2020 ), and for sciatic nerve regeneration (Farjah et al, 2020 ).…”

“…In many studies the ESM is used as a template or framework, forming a composite with bioactive molecules or nanoparticles embedded into its structure (Jun et al, 2014 ; Li et al, 2016 , 2019b ; Puertas-Bartolome et al, 2018 ; Augustine et al, 2019 ; Raz et al, 2019 ; Farjah et al, 2020 ; Krishnan et al, 2020 ; Selvam et al, 2020 ). Consisting of unique interwoven shell membrane fibers, the ESM provides a unique supporting platform for functional nanoparticles in catalysis and sensing (Vuong et al, 2017 ).…”

“…The Ag NPs/ESM composites had a higher surface area (159.08 m 2 /g), than the natural ESM (24.32 m 2 /g) and a suitable average pore size (10.92 nm). Hence, Ag NPs/ESM composites displayed better absorption and antibacterial abilities (Krishnan et al, 2020 ). Several techniques to produce composite materials based on ESM and Ag NPs have been reported.…”