Silver nanoparticle uptake in the human lung assessed through in-vitro and in-silico methods

Jalink, Kathryn; Cheng, Sammi Sham Yin; Ireland, Samantha; Meunier, M.A.F. Louise

doi:10.1016/j.envpol.2019.113880

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…The Trojan horse mechanism is the process by which AgNPs are internalized to exert cytotoxicity within the cell. More precisely, AgNPs are internalized by lung cells and undergo dissolution, liberating high loads of toxic ions [154]. Once the AgNPs are internalized, released silver ions or AgNPs which are translocated directly to the mitochondria or the nucleus, promoting oxidative damage that could lead to cell death.…”

Section: Trojan Horse Mechanism Exerting Lung Cell Death Mainly By P5...mentioning

confidence: 99%

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

et al. 2022

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Nanomaterials (NMs) solve specific problems with remarkable results in several industrial and scientific areas. Among NMs, silver nanoparticles (AgNPs) have been extensively employed as drug carriers, medical diagnostics, energy harvesting devices, sensors, lubricants, and bioremediation. Notably, they have shown excellent antimicrobial, anticancer, and antiviral properties in the biomedical field. The literature analysis shows a selective cytotoxic effect on cancer cells compared to healthy cells, making its potential application in cancer treatment evident, increasing the need to study the potential risk of their use to environmental and human health. A large battery of toxicity models, both in vitro and in vivo, have been established to predict the harmful effects of incorporating AgNPs in these numerous areas or those produced due to involuntary exposure. However, these models often report contradictory results due to their lack of standardization, generating controversy and slowing the advances in nanotoxicology research, fundamentally by generalizing the biological response produced by the AgNP formulations. This review summarizes the last ten years’ reports concerning AgNPs’ toxicity in cellular respiratory system models (e.g., mono-culture models, co-cultures, 3D cultures, ex vivo and in vivo). In turn, more complex cellular models represent in a better way the physical and chemical barriers of the body; however, results should be used carefully so as not to be misleading. The main objective of this work is to highlight current models with the highest physiological relevance, identifying the opportunity areas of lung nanotoxicology and contributing to the establishment and strengthening of specific regulations regarding health and the environment.

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Section: Trojan Horse Mechanism Exerting Lung Cell Death Mainly By P5...mentioning

confidence: 99%

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

et al. 2022

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“…Although the average short-term exposure concentrations were 3 orders of magnitude smaller than the reported threshold for mammalian cytotoxicity effects (observed at 5000 ppb), cumulative impacts resulting from constant exposure to AgNP may pose risks to human health in the long term, with predicted bioaccumulation reaching potential toxic effects after only five months of exposure, based on maximum flux. 298 Chang, X. et al also investigated the biological effects of silver NPs mediated cytotoxicity using the mouse hippocampal neuronal cell line (HT22 cells). The excessive production of reactive oxygen species due to the dose of 25−100 μg mL −1 for 24 h led to oxidative stress in the cell line.…”

Section: Toxicity Of Inhaled Nanoparticlesmentioning

confidence: 99%

“…Results from in-silico simulations were consistent with values estimated in vitro (within an order of magnitude), which suggested that CFD models may be used effectively to predict silver exposure from inhaled AgNP. Although the average short-term exposure concentrations were 3 orders of magnitude smaller than the reported threshold for mammalian cytotoxicity effects (observed at 5000 ppb), cumulative impacts resulting from constant exposure to AgNP may pose risks to human health in the long term, with predicted bioaccumulation reaching potential toxic effects after only five months of exposure, based on maximum flux . Chang, X. et al also investigated the biological effects of silver NPs mediated cytotoxicity using the mouse hippocampal neuronal cell line (HT22 cells).…”

Section: Toxicity Of Inhaled Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary Diseases

Pramanik

Mohanto

Manne³

et al. 2021

Mol. Pharmaceutics

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Chronic pulmonary diseases encompass different persistent and lethal diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), asthma, and lung cancers that affect millions of people globally. Traditional pharmacotherapeutic treatment approaches (i.e., bronchodilators, corticosteroids, chemotherapeutics, peptide-based agents, etc.) are not satisfactory to cure or impede diseases. With the advent of nanotechnology, drug delivery to an intended site is still difficult, but the nanoparticle’s physicochemical properties can accomplish targeted therapeutic delivery. Based on their surface, size, density, and physical-chemical properties, nanoparticles have demonstrated enhanced pharmacokinetics of actives, achieving the spotlight in the drug delivery research field. In this review, the authors have highlighted different nanoparticle-based therapeutic delivery approaches to treat chronic pulmonary diseases along with the preparation techniques. The authors have remarked the nanosuspension delivery via nebulization and dry powder carrier is further effective in the lung delivery system since the particles released from these systems are innumerable to composite nanoparticles. The authors have also outlined the inhaled particle’s toxicity, patented nanoparticle-based pulmonary formulations, and commercial pulmonary drug delivery devices (PDD) in other sections. Recently advanced formulations employing nanoparticles as therapeutic carriers for the efficient treatment of chronic pulmonary diseases are also canvassed.

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“…In addition to environmental exposure, NMs and their composite systems can directly contact tissue or a damaged wound, as they are inhaled, taken orally, or even injected directly into the biological system in a medical situation [6][7][8][9]. For these considerations, a large number of studies have investigated the biological hazard of NMs through varying exposure pathways [10][11][12][13]. In view that NMs are more chemically active than their bulk counterparts, NMs distributed in different organs can cause distinct toxic effects through interacting with cells, proteins, or DNA after entering the body [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Silver nanoparticle uptake in the human lung assessed through in-vitro and in-silico methods

Cited by 9 publications

References 45 publications

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary Diseases

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

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