Silver nanoparticles (AgNPs) as a metal nano-therapy: possible mechanisms of antiviral action against COVID-19

Al‐Radadi, Najlaa S.; Abu‐Dief, Ahmed M.

doi:10.1080/24701556.2022.2068585

Cited by 28 publications

(15 citation statements)

References 160 publications

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“…In addition, Pd (0) exhibited high e cacy as a therapeutic agent for human ovarian cancer [10]. Ag-NPs exhibited great success in several biological applications due to the large surface area of their particles [11]. Ag-NPs displayed antimicrobial, cytotoxic, and antiproliferative properties e ects as previously reported [12][13][14].…”

Section: Introductionsupporting

confidence: 56%

Green Synthesis of Trimetallic Nanocomposite (Ru/Ag/Pd)-Np and Its In Vitro Antimicrobial and Anticancer Activities

Hussein

Mahmoud

Elgebaly

et al. 2022

Journal of Chemistry

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In this study, we used the aqueous extract of garlic tunicate leaf to reduce a mixture of equal amounts of ruthenium chloride, silver nitrate, and palladium acetate for the biosynthesis of ruthenium/silver/palladium trimetallic nanocomposite (Ru/Ag/Pd)-Np. Some physicochemical tools were used for nanocomposite characterization, including Fourier-transform infrared spectroscopy (FT-IR), X-ray di raction (XRD), thermal gravimetric analysis (TGA), UV-Vis spectroscopy (UV-Vis), scanning electron microscope (SEM), and transmittance electron microscope (TEM). XRD revealed that the crystal size of the nanocomposite is 15.67 nm. e TEM images showed that the particle size ranged 50-90 nm. e antimicrobial e cacy of the nanocomposite was examined against Aspergillus avus, Aspergillus niger, Candida albicans, Candida glabrata, Escherichia coli, and Bacillus cereus.e results showed a potent antimicrobial activity toward all tested microorganisms. (Ru/Ag/Pd)-Np showed antiproliferative activity against Caco-2, HepG2, and K562 cell lines. e antiproliferative potential of (Ru/Ag/Pd)-Np was signi cantly improved following UV irradiation.

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Section: Introductionsupporting

confidence: 56%

Green Synthesis of Trimetallic Nanocomposite (Ru/Ag/Pd)-Np and Its In Vitro Antimicrobial and Anticancer Activities

Hussein

Mahmoud

Elgebaly

et al. 2022

Journal of Chemistry

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“…Even the successful mRNA-based vaccine has drawbacks, requiring deep freeze storage and distribution, which is not easily amenable for low-resource settings [ 3 ]. Metal complexes have been proposed as anti-SARS-CoV-2 antibody modifiers, but this technique needs further studies [ 4 , 5 ]. Thus, exploring alternative vaccine modalities is important, as they may overcome some of the disadvantages of current ones.…”

Section: Introductionmentioning

confidence: 99%

An Escherichia coli Expressed Multi-Disulfide Bonded SARS-CoV-2 RBD Shows Native-like Biophysical Properties and Elicits Neutralizing Antisera in a Mouse Model

Brindha

Yoshizue

Wongnak

et al. 2022

IJMS

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A large-scale Escherichia coli (E. coli) production of the receptor-binding domain (RBD) of the SARS-CoV-2 could yield a versatile and low-cost antigen for a subunit vaccine. Appropriately folded antigens can potentially elicit the production of neutralizing antisera providing immune protection against the virus. However, E. coli expression using a standard protocol produces RBDs with aberrant disulfide bonds among the RBD’s eight cysteines resulting in the expression of insoluble and non-native RBDs. Here, we evaluate whether E. coli expressing RBD can be used as an antigen candidate for a subunit vaccine. The expressed RBD exhibited native-like structural and biophysical properties as demonstrated by analytical RP-HPLC, circular dichroism, fluorescence, and light scattering. In addition, our E. coli expressed RBD binds to hACE2, the host cell’s receptor, with a binding constant of 7.9 × 10−9 M, as indicated by biolayer interferometry analysis. Our E. coli-produced RBD elicited a high IgG titer in Jcl:ICR mice, and the RBD antisera inhibited viral growth, as demonstrated by a pseudovirus-based neutralization assay. Moreover, the increased antibody level was sustained for over 15 weeks after immunization, and a high percentage of effector and central memory T cells were generated. Overall, these results show that E. coli-expressed RBDs can elicit the production of neutralizing antisera and could potentially serve as an antigen for developing an anti-SARS-CoV-2 subunit vaccine.

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“…However, the main problem is the lack of disease treatment, with the vector control being the main protection strategy [ 1 , 2 ]. The use of metallic nanoparticles (MeNPs) is widely applied in medicine due to their antimicrobial, virucidal, and anticancer activities, among others [ 3 , 4 , 5 ]. This has generated a great interest in the application of nanoparticles to agriculture, especially as antiviral agents.…”

Section: Introductionmentioning

confidence: 99%

“…The objectives of this work have been: (1) to compare the micropropagation of two apricot cultivars in liquid and in semisolid media, (2) to optimize Argovit ® concentration in the culture medium to introduce the maximum possible silver within apricot shoots, (3) to study silver and other ion content in apricot shoot leaves, as affected by Argovit ® -7 concentration and the different culture systems, and (4) to study the effect of Argovit ® -7 on apricot micropropagation.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Silver Nanoparticle Addition on Micropropagation of Apricot Cultivars (Prunus armeniaca L.) in Semisolid and Liquid Media

Pérez-Caselles

Burgos

Sánchez-Balibrea

et al. 2023

Plants

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Silver nanoparticles (AgNPs) are novel compounds used as antimicrobial and antiviral agents. In addition, AgNPs have been used to improve the growth of different plants, as well as the in vitro multiplication of plant material. In this work the effect of AgNPs on in vitro growth of ‘Canino’ and ‘Mirlo Rojo’ cultivars, as well as the leaf ion composition, are studied. Different concentrations of AgNPs (0, 25, 50, 75 and 100 mg L−1) were added to two culture systems: semisolid medium with agar (SSM) in jars and liquid medium in temporary immersion system (TIS). Proliferation (number of shoots), shoot length, productivity (number of shoot × average length), leaf surface, fresh and dry weight were measured. Additionally, the silver and other ion accumulation in the leaves were evaluated by inductively coupled plasma optical emission spectroscopy (ICP-OES) analysis. The productivity of ‘Canino’ and ‘Mirlo Rojo’ decreased when increasing the concentration of AgNPs in the semisolid medium. However, the use of AgNPs in the TIS improved the proliferation and productivity of ‘Canino’ and Mirlo Rojo’, increasing biomass production, and the concentration of nutrients in the plants, although these effects are genotype-dependent. TISs are the best system for introducing silver into shoots, the optimum concentration being 50 mg L−1 for ‘Canino’ and 75 mg L−1 for ‘Mirlo Rojo’. Principal component analysis, considering all the analyzed ions along the treatments, separates samples in two clear groups related to the culture system used. The use of bioreactors with a liquid medium has improved the productivity of ‘Canino’ and ‘Mirlo Rojo’ in the proliferation stage, avoiding hyperhydration and other disorders. The amount of metallic silver that penetrates apricot plant tissues depends on the culture system, cultivar and concentration of AgNPs added to the culture medium. Silver ion accumulation measured in the shoots grown in the TIS was higher than in shoots micropropagated in a semisolid medium, where it is barely detectable. Furthermore, AgNPs had a beneficial effect on plants grown in TIS. However, AgNPs had a detrimental effect when added to a semisolid medium.

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Silver nanoparticles (AgNPs) as a metal nano-therapy: possible mechanisms of antiviral action against COVID-19

Cited by 28 publications

References 160 publications

Green Synthesis of Trimetallic Nanocomposite (Ru/Ag/Pd)-Np and Its In Vitro Antimicrobial and Anticancer Activities

Green Synthesis of Trimetallic Nanocomposite (Ru/Ag/Pd)-Np and Its In Vitro Antimicrobial and Anticancer Activities

An Escherichia coli Expressed Multi-Disulfide Bonded SARS-CoV-2 RBD Shows Native-like Biophysical Properties and Elicits Neutralizing Antisera in a Mouse Model

The Effect of Silver Nanoparticle Addition on Micropropagation of Apricot Cultivars (Prunus armeniaca L.) in Semisolid and Liquid Media

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