2024
DOI: 10.1101/2024.01.26.577516
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Silver nanoparticles can be sampled by ultrafiltration probe but elution into & recovery from plasma and DPBS differsin vitro

Marije Risselada,
Robyn R McCain,
Miriam G Bates
et al.

Abstract: We compared 1) the influence of elution fluid on rate, pattern, and completeness of silver nanoparticle (AgNP) elution, and 2) ultrafiltration (UF) probe and direct sampling in vitro. Six specimens (2.5ml of 0.02mg/ml 10nm AgNP and 5.0ml of 30% poloxamer 407) contained in a dialysis tube (12-14kDa pores) were placed in 100ml Dulbecco’s Phosphate Buffered Saline (DPBS) (n=3) or canine plasma (n=3) for 96h on a stirred hot plate (37°C and 600rpm) and sampled 20 times. Six pipette and UF probe samples were taken … Show more

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