Silver nanoparticles in X-ray biomedical applications

Mattea, Facundo; Vedelago, José; Malano, Francisco; Gómez, Cesar Gerardo; Strumia, Miriam Cristina; Valente, M.

doi:10.1016/j.radphyschem.2016.10.008

Cited by 40 publications

(15 citation statements)

References 39 publications

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“…AgNPs possess the intrinsic capability to merge with mammalian cells and to easily penetrate them by means of energy-driven internalization pathways [ 217 ]. Another attractive property of AgNPs relies on their specific fluorescence, making them suitable candidates for detection and dose-enhancement purposes in X-ray irradiation applications [ 218 ].…”

Section: Silver Nanoparticles For Other Medical Applicationsmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

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Section: Silver Nanoparticles For Other Medical Applicationsmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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“…Adding methyl alcohol and Ag salts in the solution can partially neutralize and condense the hydrogel polymer chains to form large and continuous multilayer membranes via the salting‐out effect (Figure S2, Supporting Information). Conceptually, Ag ions are coordinated on the randomly coiled gelatin chains, which are rapidly accumulated under elevated temperature to form a multilayered structure ( Figure a) . The neutralization and condensation process occurs, and the Ag ions are trapped between the layers of the hydrogel scaffold (Figure b).…”

mentioning

confidence: 99%

Ultrafast Growth of Large 2D Silver Nanosheets by Highly Ordered Biological Template at Air/Gel Interface

Jang

Seong

Zang

et al. 2018

Adv Materials Inter

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However, dislocations, disinclinations, and symmetry-breaking instabilities can frequently prompt the formations of defects and grain boundaries in the synthesis processes [15,16] and crystal growth rate of the 2D nanostructure is very slow. [17,18] In nature system, organic-inorganic hybrid nanostructures with high-crystallinity and diverse morphologies can be constructed by biomineralization process. [19,20] This natural process can efficiently induce the molecular rearrangement for high complexity [21] and many functionalities. [22,23] Therefore, these unique biological phenomena have been applied in synthesis method to control the crystallinity and morphology of 2D nanostructures with superior material properties. Here, we show a solution-based ultrafast 2D growth method for large-scale and high-quality silver nanosheets on air/gel interface. The biological hydrogel polymer forms a multilayered structure by a solvent-induced phase separation process at air/gel interface with trapped silver (Ag) salts between the layers. [24] Furthermore, the trapped Ag salts between each biological hydrogel layers can efficiently reduce into large-scale 2D Ag nanosheets during the annealing process.The mixture of the Ag salts and hydrogel solution is a transparent, light yellow color at room temperature with reduced viscosity as compared with pure gelatin solution (Figure S1a, Supporting Information), while its nominal phase-change temperature is 154 °C based on the thermal gravimetric analysis (TGA) analysis results ( Figure S1b, Supporting Information). The viscosity of the hydrogel mixture decreases further at above 40 °C as the hydrogen bond in the triple-helix gelatin chain [25] degrades by the intercalation of Ag ions between various functional side chains (e.g., amine, carboxyl, hydroxyl, and thiolate groups). [26] Adding methyl alcohol and Ag salts in the solution can partially neutralize and condense the hydrogel polymer chains [24,27] to form large and continuous multilayer membranes via the salting-out effect ( Figure S2, Supporting Information). Conceptually, Ag ions are coordinated on the randomly coiled gelatin chains, which are rapidly accumulated under elevated temperature to form a multi layered structure (Figure 1a). [28] The neutralization and condensation process occurs, and the Ag ions are trapped between the layers of the hydrogel scaffold (Figure 1b). A reducing agent, dopamine, is used to promote the conversion of Ag ions to atoms while large, multilayered gelatin scaffolds constrain the crystallization process laterally to increase the The growth of large and high-quality 2D nanomaterials is challenging due to the formation of defects from dislocations, disinclinations, and symmetrybreaking instabilities. In this study it is demonstrated that biological template can be utilized to align the molecular orientation for large grain size in the synthesis of the high-quality 2D silver nanostructure. The solvent assisted multilayering phenomenon of hydrogel forms biological template at the air/ gel interface...

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“…A post-reaction purification process was necessary to eliminate the remaining silver ions from the products for their further use in Fricke gel dosimetry [16].…”

Section: Purification Processmentioning

confidence: 99%

“…Secondly, to study the fluorescence detection in Fricke gel dosimeters, the Ag NPs products were placed inside polymethylmethacrylate (PMMA) cuvettes within a poly(ethylene terephthalate) (PET) phantom. These samples were irradiated configuring the setup as described elsewhere [16] delivering the same total dose (12 Gy). The scattered spectrum was detected by an AMPTEK XR-100T Cd-Te γ/X-ray detector.…”

Section: X-ray Irradiationsmentioning

confidence: 99%

“…For that purpose, gel dosimetry represents a promising tool due to its three-dimensional capability and tissue equivalence [15]. Furthermore, the addition of inorganic salts and particles could turn gel dosimeters unstable [16] and the compatibilization of the nanoparticles with the dosimetric material must be considered in the material design. There are many methods for the production and desing of nanoparticles, most of them are generally costly, energy intensive or harmful to human and environment.…”

Section: Introductionmentioning

confidence: 99%

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