Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

“…4,17,18 A large number of previous studies have shown that, compared with the silver ions, the cytotoxicity of AgNPs has been greatly decreased; however, AgNPs still induce cell damage through induction of apoptosis. [19][20][21] The cytotoxicity of AgNPs could be influenced by particle size, surface-stabilizing agents, pH, and some other factors. 1,5,7,[22][23][24] The surface-stabilizing coating is one of the most important factors for protecting cell viability from AgNPs.…”

Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis

“…38,39 Many reports have demonstrated the relationship of AgNPsmediated cytotoxic and oxidative stress, but the anticancer mechanisms of AgNPs have remained poorly understood. 40,41 Thus, Ag@PEI@PTX was synthesized as a novel chemotherapeutic agent to achieve HepG2 apoptosis.…”

Silver_ nanoparticles inhibited erythrogenesis during zebrafish embryogenesis

“…Numerous reports discussed the cytotoxicity, genotoxicity and developmental toxicity of AgNPs (Soares et al, 2016;Sun et al, 2016;Wang et al, 2013), but which sources of AgNPs mediating toxicity, particles, ions, or both, remained controversial till today. Some studies reported that toxicokinetic profiles of AgNPs were totally different from those of ions silver (Ag + ), and AgNPs produced toxicity mostly by their particles (Osborne et al, 2015;Qian et al, 2015;Wang et al, 2013).…”

“…(Bar-Ilan et al, 2009;Choi et al, 2010). Moreover, AgNPs induced behavioral abnormality and affected neural development during rodents development (Ema et al, 2015;Sun et al, 2016), induced neurotoxicity through oxidative stress in rat cerebral astrocytes (Ema et al, 2015;Sun et al, 2016). It was also reported that AgNPs induced cardiac malformation, yolk sac edema, head edema and eye abnormality during fish embryogenesis Lee et al, 2013;Lee et al, 2007).…”