Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis

Enhancing Healing of Infected Wounds with Glycerin‐Modified Sodium Alginate/Silk Sericin Composite Film Functionalized with Polygonatum sibiricum Polysaccharide‐Capped Silver Nanoparticles

“…We propose that the increased cell viability values represent the promotion of cell proliferation by SS leaching from the films [56] . The viability promotion effect of the SA/SS/GI/PSP@AgNP composite film was slightly lower than that of the other films, which may be attributed to an inhibitory effect of PSP@AgNP released from the film [20] …”

“…[56] The viability promotion effect of the SA/SS/GI/PSP@AgNP composite film was slightly lower than that of the other films, which may be attributed to an inhibitory effect of PSP@AgNP released from the film. [20] The hemolytic activities of leaching solutions from the SA/ SS, SA/SS/GI, and SA/SS/GI/PSP@AgNP composite films are shown in Figure 11B. In this assay, the positive control, pure water, led to the development of red color, indicating the expected hemolysis; the negative control sample (PBS) remained transparent and colorless, indicating the lack of hemolysis.…”

“…The PSP@AgNP nanoparticles were prepared as previously described. [20][21] Briefly, solutions of PSP Solutions of PSP (1.0 mg/ mL) and AgNO 3 (10.0 mM) were mixed in a 1 : 1 ratio (v/v) and stirred on a magnetic stirrer (400 rpm) at 35 °C under nitrogen. NaBH 4 was quickly added in an equimolar amount relative to AgNO 3 , and the mixture was continuously stirred for 70 min under nitrogen to allow for reaction.…”

“…These PSP@AgNPs showed a strong bactericidal ability against E. coli and S. aureus. [20] In the present work, SA/SS films were prepared by utilizing the active hydroxyl groups of SA and SS to form biomaterials with specific mechanical properties under the cross-linking action of Ca 2 + , and GI was added to these films to modify their properties. We also optimized the amount of PSP@AgNPs to create a functional composite film of sodium alginate/silk sericin/glycerin/Polygonatum polysaccharide@silver nanoparticles (SA/SS/GI/PSP@AgNP).…”

“…Previously, we used Polygonatum polysaccharide as a template to create Polygonatum sibiricum polysaccharide@silver nanoparticles (PSP@AgNPs). These PSP@AgNPs showed a strong bactericidal ability against E. coli and S. aureus [20] …”