Silver nanoparticles synthesis from Bacillus sp KFU36 and its anticancer effect in breast cancer MCF-7 cells via induction of apoptotic mechanism

Almalki, Mohammed A.; Khalifa, Ashraf

doi:10.1016/j.jphotobiol.2020.111786

Cited by 59 publications

(22 citation statements)

References 33 publications

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“…Silver forms the most essential nanoparticles due to its physicochemical properties (Maddinedi et al, 2017). Synthesis of silver nanoparticles by biological or green methods has attracted the attention of researchers due to their low-cost, eco-friendly approach, high thermal stability and various biological applications in medicinal and pharmaceuticals (Almalki & Khalifa, 2020;Bindhu et al, 2020;Jiang et al, 2020;Marimuthu et al, 2020;Rahisuddin et al, 2017). Nowadays, researchers are using microorganisms like bacteria, fungi, yeasts and plant extracts for the synthesis of silver nanoparticles with significant biological properties.…”

Section: Introductionmentioning

confidence: 99%

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Arif

Uddin

2020

Med Devices & Sens

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Green chemistry is the significant field of research as it offers simple, cost-effective, easy, biocompatible and eco-friendly methods for the synthesis of nanomaterials. With the development of nanotechnology, the synthesis of silver nanoparticles (AgNPs) has become important areas of research due to their various applications in industrial, pharmacological and medicinal fields as they exhibited good antibacterial, antifungal, antioxidant, anti-inflammatory, antiviral, anticoagulant, thrombolytic, cytotoxic and photocatalytic properties due to their chemical stability and good biocompatibility.How to cite this article: Arif R, Uddin R. A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications.

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Section: Introductionmentioning

confidence: 99%

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Arif

Uddin

2020

Med Devices & Sens

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“…Therefore, it found that these nanoparticles induced the inhibition of the proliferation rate of intramacrophage amastigotes and also can be effective in reducing infected macrophages. As reported in previous studies, silver nanoparticles are able to induce programmed cell death in different cells [ 34 – 36 ]. Also, our findings showed that regarding to control group (promastigotes without treatment), induction of apoptosis was increased in promastigotes of L .…”

Section: Discussionmentioning

confidence: 59%

Efficacy of green synthesized silver nanoparticles via ginger rhizome extract against Leishmania major in vitro

et al. 2021

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Introduction Leishmaniasis is a major public health problem that causes by parasite of the genus Leishmania. The pentavalent antimonial compounds that used for treatment are not safe or effective enough. The aim of the present study was preparation and evaluation of the efficacy of green synthesized silver nanoparticles against Leishmania major (L. major) in vitro. Methods To synthesis silver (Ag) nanoparticles (NPs), ginger extract was added to the 0.2mM AgNO3 aqueous solution (1:20). Effects of different concentrations of Ag-NPs on the number of L. major promastigotes were investigated using counting assay. The MTT test was applied to determine the toxicity of Ag-NPs on promastigotes of L. major, as well as, macrophage cells. Then, to evaluate the anti-amastigotes effects of Ag-NPs, parasites within the macrophages were counted by light microscope. Furthermore, to determine the induced apoptosis and necrotic effects of Ag-NPs on promastigotes, flow cytometry method was employed using annexin staining. Results The effect of Ag-NPs on promastigotes and amastigotes of L. major was effective and has a reverse relationship with its concentration. According to the results of anti-amastigote assay, the IC50 value of this nanoparticle was estimated 2.35 ppm after 72h. Also, Ag-NPs caused Programmed Cell Death (PCD) in promastigotes of L. major and showed 60.18% of apoptosis. Discussion Based on the mentioned results, it can be concluded that Ag NPs has a beneficial effect on promastigote and amastigote forms of L. major in vitro. Hence, these nanoparticles could be applied as promising antileishmanial agents for treatment of Leishmania infections.

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“…A dose-dependent anticancer effect was reported, as the local increase of ROS led to mitochondrial impairment and DNA damage [250]. The same cytotoxic effects were evidenced after cellular treatment with AgNPs biosynthesized with extract from Ochradenus arabicus medicinal shrub [251] and marine bacilli [252]. Synergistic toxicity against breast cancer cells were reported by using Capecitabine-loaded citrate-capped AgNPs [253] and Gemcitabine-loaded PVP-stabilized nanosilver [235].…”

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 91%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Silver nanoparticles synthesis from Bacillus sp KFU36 and its anticancer effect in breast cancer MCF-7 cells via induction of apoptotic mechanism

Cited by 59 publications

References 33 publications

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications

Efficacy of green synthesized silver nanoparticles via ginger rhizome extract against Leishmania major in vitro

An Updated Review on Silver Nanoparticles in Biomedicine

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