Silver Nanoparticles Synthesis Using <i>Coccinia grandis</i> (L.) Voigt and <i>Momordica charantia</i> L., Its Characterization and Biological Screening

Mala, M.; Hepsibah, A. Hannah; Jothi, G.

doi:10.1166/jbns.2017.1480

Cited by 8 publications

(3 citation statements)

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“…M. charantia contains triterpenoids 11,39,47 , saponins 48 , polypeptides 49 , flavonoids 14,50,51 , alkaloids 40,52,53 and sterols 13,[54][55][56] , which are distributed throughout the entire plant. The seed is not edible, it contains extractable oils, mostly a conjugated triene cis-9, trans-11, trans-13 (c9, t11, t13) conjugated isomer of linolenic acid, known as α-elestearic acid (α-ESA).…”

Section: Chemical Compositionmentioning

confidence: 99%

“…5 M. Charantia is a plant belonging to the Cucurbitaceae family and is widely distributed in tropical and subtropical areas around the world. [5][6][7] Studies have determined that this plant contains a great diversity of primary and secondary metabolites 8,9 with therapeutic potential as antiulcer properties 6,10 , antioxidant [11][12][13][14] , antimicrobial 6,8,12,[15][16][17] , anthelmintic 18,19 , antidiabetic 6,11,20,21 , antiinflammatory 21,22 , antihyperglycemic 6,21,23 and anticancer 4,19,21,24 , and nutritional as antilipolytic. 11,25 Bacterial resistance is one of the main problems around the world, it is thought that by 2050 bacterial resistance will be one of the leading causes of death in the world.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity and Chemical Composition of Momordica Charantia: A Review

Torre¹,

Sagástegui-Guarniz²,

Silva-Correa³

et al. 2020

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Bitter melon, bitter cucumber or bitter gourd are some of the names given to M. charantia. It belongs to the Cucurbitaceae family. 44 M. charantia is a vegetable with many culinary uses, especially in Asia and Africa, and is commonly cultivated in Africa, India, Malaysia, China and South America. 44,45 M.ABSTRACT Momordica charantia L. (bitter melon) is a plant belonging to the Cucurbitaceae family and is widely distributed in tropical and subtropical areas around the world, mainly in Asia, India, China and Brazil, where it is traditionally used as a medicinal plant, and the fruits of some varieties of M. charantia are consumed as food. Studies have determined that this plant contains a great diversity of bioactive compounds with therapeutic potential like charantin, α-momorcharin and MAP30, and highlighting its properties as antidiabetic, antiulcer, antioxidant, antimicrobial, anthelmintic, antihyperglycemic and anticancer. Review shows the complete botanical description of the plant (fruits, leaves, stem, etc.), the bioactive chemical compounds reported in the plant species, the antimicrobial activity of the extracts or fractions of M. charantia, emphasizing the antibacterial and antifungal activities, with respective values of MIC (Minimum Inhibitory Concentration) reported according to the methodology used in each study. The review seeks to update the phytochemical and pharmacological knowledge of M. charantia, which would be useful for researchers in their search for new chemical compounds of the plant, studies of its safety and efficacy, as well as the evaluation of its possible synergistic action in combination with other antimicrobials, in order to find new therapeutic alternatives against bacterial resistance.

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Section: Chemical Compositionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity and Chemical Composition of Momordica Charantia: A Review

Torre¹,

Sagástegui-Guarniz²,

Silva-Correa³

et al. 2020

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“…There are around more than 600 commercially used herbal formulations available in the market globally, which claim to possess hepatoprotective activity 5 Coccinia grandis (L.) voigt (Ivy gourd), a member of Cucurbitaceae, is a dioecious, perennial and herbaceous climber Coccinia grandis (L.) voigt (Ivy gourd), member of Cucurbitaceae, is a dioecious, perennial and herbaceous climber Coccinia grandis (L.) voigt (Ivy gourd), member of Cucurbitaceae is a dioecious, perennial and herbaceous climber Coccinia grandis (L.) voigt (Ivy gourd), belonging to family Cucurbitaceae, is a dioecious, perennial and herbaceous climber plant 6 . The fruit, when ripped, becomes red, ovoid to elliptical, having a length 25-60 mm long, 15-35 mm in diameter, and hairless on stalks 10-40 mm long 7 .…”

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confidence: 99%

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2023

IJPSR

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To investigate the hepatoprotective activity of Coccinia grandis fruit extract against anti-tubercular drugs induced hepatotoxicity in rats. 50% ethanolic extract of Coccinia grandis (CGE 200 and 400 mg/kg body weight) was administered daily for 9 days in experimental animals. To develop hepatotoxicity, animals were administered orally with Isoniazid (50 mg/kg, p.o.) and Rifampicin (100 mg/kg, p.o.) at 2 h after the doses of CGE every day for nine consecutive days except for rats in the normal group. The hepatoprotective activity was determined using different biochemical parameters such asalanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin (ALB), Bilirubin (BIL), Cholesterol (CHL) and lactate dehydrogenase (LDH). Histopathological examinations further accomplished the hepatoprotective effect of the CDE. The results obtained demonstrated that the treatment with Coccinia grandis significantly (P<0.05-P<0.001) and dose-dependently prevented the druginduced increase in serum levels of hepatic enzymes. Histopathology of liver tissue showed that Coccinia grandis attenuated the hepatocellular necrosis, regeneration, and repair of cells toward normal. The results of this study strongly indicate the protective effect of Coccinia grandis against liver injury, which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. INTRODUCTION:The development of druginduced hepatotoxicity (DIH) during chemotherapy for TB is the most common reason leading to interruption of therapy. Wide variations have been found in the incidence of hepatotoxic reactions during short-course chemotherapy from different countries with the reported incidence being 3% in the USA, 4% in UK,

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