Silver nanoparticles testicular toxicity in rat

Elsharkawy, Eman E.; El-Nasser, Mahmoud Abd; Kamaly, Heba F.

doi:10.1016/j.etap.2019.103194

Cited by 32 publications

(20 citation statements)

References 52 publications

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“…For the detection of oxidative stress and lipid peroxidation in testicular tissue, we have measured the levels of CAT and GSH and it was found that exposure to Ag-NPs decreases the levels of testicular antioxidants and increases MDA content. These results are in agreement with the results demonstrated by Arisha et al 58 and Elsharkawy et al 59 The endocrine control of reproduction in male starts with the secretion of GnRH from the hypothalamus, which stimulates the pituitary gland to synthesize and secrete gonadotropins (LH and FSH). Under the stimulation of LH, Leydig cells secrete testosterone which acts with FSH to regulate the function of Sertoli cells.…”

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confidence: 93%

“…In line with these results, several studies reported a change in FSH, LH, and testosterone following exposure to Ag-NPs. 41,58,59,62 The decreased levels of LH and FSH may result from Ag-NPs-induced damage of the hypothalamus or the pituitary gland. According to Trickler et al, 63 Ag-NPs increase the permeability of the blood-brain barrier and can easily cross it and cause damage to these glands.…”

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confidence: 99%

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Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Shehata

Salem

El-Saied

et al. 2021

IJN

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Introduction: Silver nanoparticles (Ag-NPs) are among the most commonly used nanoparticles in different fields. Zinc nanoparticles (Zn-NPs) are known for their antioxidant effect. This study was designed to investigate the adverse effects of Ag-NPs (50 nm) on the male reproductive system and also the ameliorative effect of Zn-NPs (100 nm) against these harmful effects. Methods: Forty adult male rats were used in this study; they were randomly divided into four equal groups: control group, Ag-NPs group, Zn-NPs group, Ag-NPs + Zn-NPs group. Ag-NPs (50 mg/kg) and/or Zn-NPs (30 mg/kg) were administered orally for 90 days. Results:The results revealed that exposure to Ag-NPs adversely affected sperm motility, morphology, viability, and concentration. Ag-NPs also induced oxidative stress and lipid peroxidation in testicular tissue. The exposure to Ag-NPs decreased serum FSH, LH, and testosterone hormones. Additionally, comet assay revealed DNA degeneration in the testicular tissue of rats exposed to Ag-NPs. Histopathological examination showed various histological alterations in the testes of rats intoxicated with Ag-NPs. Furthermore, coadministration of Zn-NPs ameliorated most of the toxic effects of Ag-NPs via their antioxidative capacity.

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confidence: 93%

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confidence: 99%

Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Shehata

Salem

El-Saied

et al. 2021

IJN

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“…Sprague Dawley rats were orally exposed to silver nanoparticles (8.94-33.4 nm) for 6 months at doses of 5.36 and 13.4 mg/kg. A significant decrease in testosterone levels, an increase in luteinizing hormone levels, a decrease in superoxide dismutase activity, an increase in malondialdehyde levels, and a decrease in sperm viability were found [33]. Intraperitoneal administration of silver nanoparticles (less than 100 nm) led to dose-and time-dependent damage to the tissues of the testes of rats [34].…”

Section: Resultsmentioning

confidence: 95%

Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles

et al. 2021

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Since ancient times, silver has been known for its pronounced bactericidal, antiviral and fungicidal properties. Currently, nanoparticles of this metal are widely used in the food, light and pharmaceutical industries, as well as in medicine. Silver in any form can have a toxic effect not only on pathogens, but also on healthy cells. The biological activity and bioavailability of silver preparations depend on the degree of their solubility in water. In addition, the maximum permissible concentration of soluble forms of silver is an order of magnitude lower than that of insoluble forms. This makes nanoparticles of silver with a hydrophilic coating that form stable colloidal solutions in aqueous media potentially unsafe objects. In this work, we studied the kinetics of the accumulation of silver nanoparticles with an average size of 34 ± 5 nm stabilized with polyvinylpyrrolidone in the organs of laboratory C57Bl/6 mice. The administration of nanoparticles was carried out orally for 30, 60, 120 and 180 days at the dose of 50 µg/day/animal. All the mice developed and gained weight normally during the experiment. No adverse effects were observed. Determination of the silver content in biological tissues of mammals was accomplished by neutron activation analysis. The masses and concentrations of silver in the brain and its different sections (hippocampus, cerebellum, cortex and remnants), as well as in the lungs, testes, liver, blood, kidneys, spleen and heart, were determined. The injection times at which the accumulation curves reached saturation were established. An extremely high accumulation of silver in the testes was shown at 120 days of administration, and a significant accumulation of silver in the lungs and brain was observed. The accumulation of silver in all parts of the brain except the cortex was significant, and its trend was similar to that in the whole brain.

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“…As regards human beings, prolonged exposures to AgNPs can cause argyria (Richter et al, 2015), whose symptoms include blue gray skin color changes and multiple alterations of bodily functions such as gastrointestinal disorders, spasms, and even death (Rice, 2009). Importantly, AgNPs have produced genotoxicity in the testicles of Sprague Dawley rats (Elsharkawy et al, 2019) and in the embryos of Zebrafish (Chakraborty et al, 2016). As regards human beings, AgNPs have showed genotoxicity in human liver HepG2 and colon Caco2 cells (Sahu et al, 2016).…”

Section: Biosafety Concerns Of Npsmentioning

confidence: 99%

Targeting Tunable Physical Properties of Materials for Chronic Wound Care

Wang

Armato

2020

Front. Bioeng. Biotechnol.

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Chronic wounds caused by infections, diabetes, and radiation exposures are becoming a worldwide growing medical burden. Recent progress highlighted the physical signals determining stem cell fates and bacterial resistance, which holds potential to achieve a better wound regeneration in situ. Nanoparticles (NPs) would benefit chronic wound healing. However, the cytotoxicity of the silver NPs (AgNPs) has aroused many concerns. This review targets the tunable physical properties (i.e., mechanical-, structural-, and size-related properties) of either dermal matrixes or wound dressings for chronic wound care. Firstly, we discuss the recent discoveries about the mechanical-and structural-related regulation of stem cells. Specially, we point out the currently undocumented influence of tunable mechanical and structural properties on either the fate of each cell type or the whole wound healing process. Secondly, we highlight novel dermal matrixes based on either natural tropoelastin or synthetic elastin-like recombinamers (ELRs) for providing elastic recoil and resilience to the wounded dermis. Thirdly, we discuss the application of wound dressings in terms of size-related properties (i.e., metal NPs, lipid NPs, polymeric NPs). Moreover, we highlight the cytotoxicity of AgNPs and propose the size-, dose-, and time-dependent solutions for reducing their cytotoxicity in wound care. This review will hopefully inspire the advanced design strategies of either dermal matrixes or wound dressings and their potential therapeutic benefits for chronic wounds.

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Silver nanoparticles testicular toxicity in rat

Cited by 32 publications

References 52 publications

Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles

Targeting Tunable Physical Properties of Materials for Chronic Wound Care

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