Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria

Rai, Mahendra; Deshmukh, Shivaji; Ingle, Avinash P.; Gade, Aniket

doi:10.1111/j.1365-2672.2012.05253.x

Cited by 1,280 publications

(905 citation statements)

References 68 publications

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“…Silver-containing systems, and notably silver nanoparticles (Ag NPs) are to these days one of the most promising system to fill this role [6][7][8]. Silver as a disinfectant has (empirically) been used for several millennia metallic nanoparticles), as referenced in several very complete reviews [9,13,14].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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Summary Silver nanoparticles constitute a very promising approach for the development of new antimicrobial systems. Nanoparticulate objects can bring significant improvements in the antibacterial activity of this element, through specific effect such as an adsorption at bacterial surfaces. However, the mechanism of action is essentially driven by the oxidative dissolution of the nanoparticles, as indicated by recent direct observations. The role of Ag + release in the action mechanism was also indirectly observed in numerous studies, and explains the sensitivity of the antimicrobial activity to the presence of some chemical species, notably halides and sulfides which form insoluble salts with Ag + . As such, surface properties of Ag nanoparticles have a crucial impact on their potency, as they influence both physical (aggregation, affinity for bacterial membrane, etc.) and chemical (dissolution, passivation, etc.) phenomena. Here, we review the main parameters that will affect the surface state of Ag NPs and their influence on antimicrobial efficacy. We also provide an analysis of several works on Ag NPs activity, observed through the scope of an oxidative Ag + release.

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Section: Introductionmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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“…A variety of strategies, such as the replacement of contaminated catheters, novel materials for catheter production and surface functionalization with antibacterial agents have been suggested [4,15], including rifampicin, sparfloxacin and triclosan have been proposed for impregnation of urinary catheters [4]. Currently, the use of silver in biomedical field is increasing because of its broadspectrum antimicrobial activity demonstrated against multi-drug resistant bacteria, fungi and viruses [19,20]. At nanometric size, silver is extremely active against microorganisms due to the high surface to volume ratio [21].…”

Section: Introductionmentioning

confidence: 99%

The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

Cooper

Pollini

Paladini

2016

Materials Science and Engineering: C

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Catheter-associated urinary tract infection (CAUTI) represents one of the most common causes of morbidity and mortality. The resistance demonstrated by many microorganisms to conventional antibiotic therapies and the in-creasing health-care costs have recently encouraged the definition of alternative preventive strategies, which can have a positive effect in the management of infections.Antimicrobial urinary catheters have been developed through the photo-chemical deposition of silver coatings on the external and luminal surfaces. The substrates are exposed to ultraviolet radiation after impregnation into a silver-based solution, thus inducing the in situ synthesis of silver particles. The effect of the surface treatment on the material was investigated through scanning electron microscopy (SEM) and silver ion release measurements. The ability of microorganisms commonly associated with urinary tract infections was investigated in terms of bacterial viability, proliferation and biofilm development, using Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis as target organisms. The silver coatings demonstrated good distribution of silver particles to the substrate, and proved an effective antibacterial capability in simulated biological conditions.The low values of silver ion release demonstrated the optimum adhesion of the coating. The results indicated a good potential of silver-based antimicrobial materials for prevention of catheterassociated urinary tract infection.

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“…This molecule is relatively stable under physiological conditions and can oxidize lipids, proteins, DNA and other organic molecules (Bienert et al 2007). It is known that silver ions are highly reactive and can interfere with numerous biological processes in microorganisms, including structural and functional alterations of cell membrane and cell wall (Jo et al 2009, Rai et al 2012. Silver ions can inhibit replication by binding to DNA molecule (Landsdown 2002, Castellano et al 2007).…”

Section: Morpho-physiological Changesmentioning

confidence: 99%

Comparison of anti-Aspergillus activity of Origanum vulgare L. essential oil and commercial biocide based on silver ions and hydrogen peroxide

Savković¹,

Stupar²,

Grbić³

et al. 2016

Acta Botanica Croatica

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-The antifungal activities of Origanum vulgare essential oil (EO) and of a biocide based on silver and hydrogen peroxide (Sanosil S003) against seven Aspergillus species isolated from different substrata (stone, brick, silk and paper) of cultural heritage objects in Serbia were evaluated. Microdilution, agar dilution and microatmosphere methods were used to determine minimal fungistatic and minimal fungicidal concentrations (MIC and MFC), and light microscopy to determine structural abnormalities. MIC and MFC values for O. vulgare EO ranged from 0.2 to 5 mg mL −1 and for Sanosil S003 from 5 to 250 mg mL −1 . Aspergillus sp. sect. fumigati was the most susceptible isolate, where MIC and MFC values were achieved at 0.5 mg mL −1 for O. vulgare EO, while MIC and MFC values for Sanosil S003 were achieved at 5 and 10 mg mL −1 , respectively. Morpho-physiological changes were documented in all isolates, including lack of sporulation, depigmentation of conidiogenous apparatus and conidia, and presence of aberrant fungal structures. O. vulgare EO exhibited stronger anti-Aspergillus activity than Sanosil S003, as demonstrated by the higher MIC and MFC values and fewer morpho-physiological changes observed in the tested Sanosil S003 concentrations. O. vulgare EO could be an excellent alternative to commercial biocides, with high potential in the fi eld of cultural heritage conservation.

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Silver nanoparticles: the powerful nanoweapon against multidrug-resistant bacteria

Cited by 1,280 publications

References 68 publications

Antibacterial activity of silver nanoparticles: A surface science insight

Antibacterial activity of silver nanoparticles: A surface science insight

The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

Comparison of anti-Aspergillus activity of Origanum vulgare L. essential oil and commercial biocide based on silver ions and hydrogen peroxide

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