Silyl Modification of Biologically Active Compounds. 14. Organosilicon Lipid-like Derivatives of Hydroxyethyl Tetrahydro(iso)quinoline and Thiazole with Antitumour, Antibacterial and Antifungal Properties

Zablotskaya, Alla; Segal, Izolda; Kazachonokh, Galina; Popelis, Yuris; Шестакова, И.; Nikolajeva, Vizma

doi:10.1007/s12633-017-9585-2

Cited by 5 publications

(9 citation statements)

References 27 publications

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“…Incorporating Si-atom through silyl moiety, tetrahydro(iso) quinoline and tetrahydro(iso)quinolinium derivatives were designed. [94] The in vitro antitumor properties revealed that Npropyltrimethylsilyl/N-methylquinolinium derivatives comparatively possessed higher anticancer properties indicating the importance of N-methyl group. Amongst these, Npropyltrimethylsilyl propyl moiety-appended tetrahydroquinolinium 67 ( Figure 6) and tetrahydroisoquinoline derivative 68 bearing ethoxydodecane chain have turned out to be eminent antitumor agents (Table 7).…”

Section: Phosphorous Silicon and Sulfur-containing Quinoline Analogsmentioning

confidence: 96%

“…[89] Compd IC 50 6. Structures of quinoline analogs containing S, Si and P. [90][91][92][93][94] Table 7. Depiction of anticancer properties of significant molecules.…”

Section: Phosphorous Silicon and Sulfur-containing Quinoline Analogsmentioning

confidence: 99%

“…Depiction of anticancer properties of significant molecules. [94] Compd Recently, a review on isatin derivatives demonstrated that quinoline and isatin analogs tethered via piperazine pharmacophore as remarkable antiproliferative agents. [95] Amongst these isatin-quinoline hybrids reported, compounds 69-71 ( Figure 7) have exerted good anticancer abilities with the IC 50 values of 10.34-15.88 μM against proliferation of MCF-7 and MDA-MB-468 cell lines.…”

Section: Phosphorous Silicon and Sulfur-containing Quinoline Analogsmentioning

confidence: 99%

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Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Dorababu¹

2020

ChemistrySelect

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Quinoline has been a most essential pharmacophore, derivatization of which led to enticing pharmacological properties. Quinoline is responsible for a wide range of biological potencies such as antibacterial, antifungal, anti-leishmanial, antimalarial, antioxidant and anticancer properties. Out of these clinical importances, the anticancer property of heterocycles is of greatest concern as cancer has become a major threat globally. Since some natural products containing quinoline moiety have displayed cancer inhibition potency, quinoline has been given highest priority in the anticancer drug design and development. In addition, quinoline has got eight positions including nitrogen for substitution which may result in some potential anticancer properties. Ever since, this extraordinary potential is being utilized in anticancer drug discovery. In this review, the various trends in drug design of quinoline moiety anticipating finest anticancer properties through cancer cell growth inhibition are collated comprehensively. The review work is classified based on type of quinoline derivatives. Besides this, with the aid of structure-activity relationship discussion, the importance of structural units that contributed to strongest activity towards cancer inhibition is emphasized. The particular activity would help to bring further advanced anticancer agents in the future.

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Section: Phosphorous Silicon and Sulfur-containing Quinoline Analogsmentioning

confidence: 96%

“…[89] Compd IC 50 6. Structures of quinoline analogs containing S, Si and P. [90][91][92][93][94] Table 7. Depiction of anticancer properties of significant molecules.…”

Section: Phosphorous Silicon and Sulfur-containing Quinoline Analogsmentioning

confidence: 99%

Section: Phosphorous Silicon and Sulfur-containing Quinoline Analogsmentioning

confidence: 99%

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Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Dorababu¹

2020

ChemistrySelect

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“…38 Similarly, organosilicon lipid-like derivatives of THIQ analogs were also reported by Zablotskaya et al Compounds 140 and 141 were found to exhibit good antibacterial activity along with DNA gyrase inhibitory action. 39 A series of 5,8-disubstituted THIQ analogs were synthesized by Lu et al The synthesized analogs were evaluated for their anti-mycobacterial property. 40 Compounds 142 and 143 (Fig.…”

Section: Anti-bacterial Activitymentioning

confidence: 99%

“…Zablotskaya and co-workers also evaluated compounds 138-141 for their antifungal property. 38,39 They exhibited potent antifungal activity as that of the standard drug uconazole.…”

Section: Anti-fungal Activitymentioning

confidence: 99%

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

et al. 2021

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Mycotoxin levels and characterization of natural anti-fungal phytochemicals in pearl millet (Pennisetum glaucum) from Nigeria’s six agroecological zones

Muhammad

Njobeh

et al. 2022

Mycotoxin Res

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Silyl Modification of Biologically Active Compounds. 14. Organosilicon Lipid-like Derivatives of Hydroxyethyl Tetrahydro(iso)quinoline and Thiazole with Antitumour, Antibacterial and Antifungal Properties

Cited by 5 publications

References 27 publications

Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

Mycotoxin levels and characterization of natural anti-fungal phytochemicals in pearl millet (Pennisetum glaucum) from Nigeria’s six agroecological zones

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