Silymarin in experiment. Liver lesions

Barterino, F.; Neuman, Eduard; Deaciuc, Ion V.; N, Ghelberg

doi:10.1016/0168-8278(90)91622-4

Cited by 1 publication

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“…[35] Barbarino et al, showed the protective effect of silymarin in acute hepatitis in rats. [36] Inhibition of galactosamine-induced lipid peroxidation was also observed in perfused rat hepatocytes. [37] When experimental hepatitis in rats was used as the model, inhibition of the toxic effects on protein synthesis was also observed.…”

Section: Hepatoprotective Activitiesmentioning

confidence: 91%

Silymarin: A review of pharmacological aspects and bioavailability enhancement approaches

et al. 2007

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Silymarin, a flavonolignan from the seeds of 'milk thistle' (Silybum marianum), has been widely used from ancient times because of its excellent hepatoprotective action. It is a mixture of mainly three flavonolignans, viz, silybin, silidianin, and silychristine, with silybin being the most active. Silymarin has been used medicinally to treat liver disorders, including acute and chronic viral hepatitis, toxin/drug-induced hepatitis, and cirrhosis and alcoholic liver diseases. It has also been reported to be effective in certain cancers. Its mechanism of action includes inhibition of hepatotoxin binding to receptor sites on the hepatocyte membrane; reduction of glutathione oxidation to enhance its level in the liver and intestine; antioxidant activity; and stimulation of ribosomal RNA polymerase and subsequent protein synthesis, leading to enhanced hepatocyte regeneration. It is orally absorbed but has very poor bioavailability due to its poor water solubility. This review focuses on the various pharmacological activities of silymarin including the clinical trials. For the first time, the review also looks at the formulation work that has been done to enhance its solubility, so as to increase its bioavailability and thus, its hepatoprotective action.

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Section: Hepatoprotective Activitiesmentioning

confidence: 91%