Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor

Hope, Sigrun; Melle, Ingrid; Aukrust, Pål; Steen, Nils Eiel; Birkenaes, Astrid B.; Lorentzen, Steinar; Agartz, Ingrid; Ueland, Thor; Andreassen, Ole A.

doi:10.1111/j.1399-5618.2009.00757.x

Cited by 139 publications

(92 citation statements)

References 70 publications

(81 reference statements)

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“…Recent researches focusing on inflammation found that depressive and manic states are associated with increased peripheral levels of pro-inflammatory cytokines, such as interleukin (IL)-2, IL-6, IL-8 and tumour necrosis factor (TNF)-α [57][58][59] and of TNF receptor 1 compared to controls [60]. Moreover, a specific profile of mRNA expression for inflammatory genes was found in bipolar subjects [61].…”

Section: Sleep and Inflammationmentioning

confidence: 97%

Chronobiology of Bipolar Disorder: Therapeutic Implication

Dallaspezia

Benedetti

2015

Curr Psychiatry Rep

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Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder arise in part from a malfunction of the circadian system, linking the disease with an abnormal internal timing. Alterations in circadian rhythms and sleep are core elements in the disorders, characterizing both mania and depression and having recently been shown during euthymia. Several human genetic studies have implicated specific genes that make up the genesis of circadian rhythms in the manifestation of mood disorders with polymorphisms in molecular clock genes not only showing an association with the disorder but having also been linked to its phenotypic particularities. Many medications used to treat the disorder, such as antidepressant and mood stabilizers, affect the circadian clock. Finally, circadian rhythms and sleep researches have been the starting point of the developing of chronobiological therapies. These interventions are safe, rapid and effective and they should be considered first-line strategies for bipolar depression.

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Section: Sleep and Inflammationmentioning

confidence: 97%

Chronobiology of Bipolar Disorder: Therapeutic Implication

Dallaspezia

Benedetti

2015

Curr Psychiatry Rep

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“…Inflammation is recognised as an integral component of both metabolic syndrome and psychiatric disorders (Hope 2009;Na 2012), with high serum levels of C-reactive protein (CRP) and proinflammatory cytokines such as interleukin IL-6 and tumour necrosis factoralpha (TNF-α) in both conditions. Genetic factors such as the presence of specific genes responsible for a predisposition to metabolic problems and variations in the leptin-melanocortin pathway that contribute to heterogeneity in antipsychoticinduced weight gain are also important causes of metabolic syndrome.…”

Section: Declaration Of Interestmentioning

confidence: 99%

“…This leads to inflammation, which ultimately confers higher risks of atherosclerosis and coronary artery disease. Blood serum levels of CRP, TNF-α and homocysteine have been found to be increased in patients with schizophrenia (Hope 2009). C-reactive protein was found to have a positive association with waist circumference and diastolic blood pressure, while homocysteine has a positive association with waist circumference, systolic and diastolic blood pressure, triglycerides and glucose (Vuksan-Cusa 2012).…”

Section: Chronic Inflammationmentioning

confidence: 99%

Metabolic syndrome in psychiatry: advances in understanding and management

Ho¹,

Zhang²,

Mak³

et al. 2014

Adv. psychiatr. treat

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SummaryMetabolic syndrome comprises a number of cardiovascular risk factors that increase morbidity and mortality. The increase in incidence of the syndrome among psychiatric patients has been unanimously demonstrated in recent studies and it has become one of the greatest challenges in psychiatric practice. Besides the use of psychotropic drugs, factors such as genetic polymorphisms, inflammation, endocrinopathies and unhealthy lifestyle contribute to the association between metabolic syndrome and a number of psychiatric disorders. In this article, we review the current diagnostic criteria for metabolic syndrome and propose clinically useful guidelines for psychiatrists to identify and monitor patients who may have the syndrome. We also outline the relationship between metabolic syndrome and individual psychiatric disorders, and discuss advances in pharmacological treatment for the syndrome, such as metformin.LEARNING OBJECTIVES•Be familiar with the definition of metabolic syndrome and its parameters of measurement.•Appreciate how individual psychiatric disorders contribute to metabolic syndrome and vice versa.•Develop a framework for the prevention, screening and management of metabolic syndrome in psychiatric patients.

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“…The possible biomarkers of mood disorder and schizophrenia in the literature, including neurotrophic factors, circulating immunological parameters, thyroid hormones, neuropeptides, and oxidative stress markers, are limited by their specificity to each disorder (45). Most schizophrenic patients in this study were not classified as BD sample by the BD-A committee on the focus array.…”

Section: Discussionmentioning

confidence: 99%

Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays

Chen

Syu

Chung

et al. 2015

Molecular & Cellular Proteomics

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To profile plasma antibodies of patients with bipolar disorder (BD), an E. coli proteome microarray comprising ca. 4200 proteins was used to analyze antibody differences between BD patients and mentally healthy controls (HCs). The plasmas of HCs and patients aged 18 -45 years with bipolar I disorder (DSM-IV) in acute mania (BD-A) along with remission (BD-R) were collected. The initial samples consisting of 19 BD-A, 20 BD-R, and 20 HCs were probed with the microarrays. After selecting protein hits that recognized the antibody differences between BD and HC, the proteins were purified to construct BD focus arrays for training diagnosis committees and validation. Additional six BD-A, six BD-R, six HCs, and nine schizophrenic disorder (SZ, as another psychiatric control) samples were individually probed with the BD focus arrays. The trained diagnosis committee in BD-A versus HC combined top six proteins, including rpoA, thrA, flhB, yfcI, ycdU, and ydjL. However, the optimized committees in BD-R versus HC and BD-A versus BD-R were of low accuracy (< 0.6). In the single blind test using another four BD-A, four HC, and four SZ samples, the committee of BD-A versus HC was able to classify BD-A versus HC and SZ with 75% sensitivity and 80% specificity that both HC and SZ were regarded as negative controls. The consensus motif of the six proteins, which form the committee of BD-A versus HC, is [KE]DIL[AG]L[LV]I[NL][IC][SVKH]G[LV][VN][LV] byGapped Local Alignment of Motifs. We demonstrated that the E. coli proteome microarray is capable of screening BD plasma antibody differences and the selected proteins committee was successfully used for BD diagnosis with

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Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor

Abstract: The present results indicate specific alterations of endothelium-related inflammation processes in both bipolar disorder and schizophrenia.

Cited by 139 publications

References 70 publications

Chronobiology of Bipolar Disorder: Therapeutic Implication

Chronobiology of Bipolar Disorder: Therapeutic Implication

Metabolic syndrome in psychiatry: advances in understanding and management

Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays

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