Similar White Matter Aberrations in Children With Autism and Their Unaffected Siblings

Barnea-Goraly, Naama; Lotspeich, Linda; Reiss, Allan L.

doi:10.1001/archgenpsychiatry.2010.123

Cited by 153 publications

(147 citation statements)

References 98 publications

(113 reference statements)

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“…10 Moreover, several DTI studies also have revealed abnormalities of the left superior longitudinal fasciculus in ASD. 17,20,23,41,44 Although the important role the left superior longitudinal fasciculus has in language processing has been known since the 19th century, the importance of this structure in the right hemisphere is emerging. Abnormalities of the right superior longitudinal fasciculus also have important implications for ASD due to its connection to the superior temporal sulcus, 42 a region well known for its role in processing biologic motion, which is abnormal in ASD.…”

Section: Discussionmentioning

confidence: 99%

“…45 Moreover, several DTI studies have revealed abnormalities of the right superior longitudinal fasciculus. 17,[20][21][22]46 Finally, similar to the inferior fronto-oc- cipital fasciculus, the superior longitudinal fasciculus also has a broad neuroanatomic extent, connecting the frontal, parietal, and temporal lobes. 42 As evident in Fig 1, this tract also may potentially serve an important role in linking all the components of brain structures involved in social cognition.…”

Section: Discussionmentioning

confidence: 99%

“…19 With the use of an optimized nonlinear registration followed by projection onto an alignment-invariant tract representation, TBSS allows for valid conclusions to be drawn from analysis of multisubject diffusion imaging studies. The procedure as implemented in the current study consists of the following steps: 1) conversion of FA data into appropriate format, 2) application of nonlinear registration so all FA images are in MNI space, 3) creation of mean FA image, 4) skeletonization of mean FA image by using an FA threshold of 0.3, 20 5) projection of all subjects' FA data onto the mean FA skeleton, and 6) submission of the 4D-projected FA data for statistical testing. Voxel-wise analysis was performed on multisubject diffusion data.…”

Section: Image Processing and Analysismentioning

confidence: 99%

“…19 At the time of this writing, it has been used in at least 4 DTI studies identifying white matter abnormalities in ASD. 17,[20][21][22] Although an encouraging trend, generalization of abnormalities cannot yet be established with such few studies; therefore, more studies sharing these procedures are needed. The current investigation responds to this need by implementing FSL with its recommended processing and analysis pipeline while also implementing a voxelwise, atlas-based tract-labeling approach not used in previously published studies.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Structural Neural Phenotype of Autism: Preliminary Evidence from a Diffusion Tensor Imaging Study Using Tract-Based Spatial Statistics

Jou

Mateljevic

Kaiser³

et al. 2011

AJNR Am J Neuroradiol

110

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Image Processing and Analysismentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Structural Neural Phenotype of Autism: Preliminary Evidence from a Diffusion Tensor Imaging Study Using Tract-Based Spatial Statistics

Jou

Mateljevic

Kaiser³

et al. 2011

AJNR Am J Neuroradiol

110

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“…While multiple white matter structures have been found to be affected in ASD (for a review, see Aoki et al, 2013;Barnea-Golary et al, 2004;Barnea-Golary et al, 2010;Olson et al, 2015), the left uncinate may be particularly important in processing socio-affective information (Pehrs et al, 2015;Olson et al, 2015). There seems to be a relatively left dominant abnormality in the uncinate fasciculus in ASD.…”

Section: Potential Neural Correlates Of Socio-affective Deficits In Amentioning

confidence: 99%

White matter structure in the uncinate fasciculus: Implications for socio-affective deficits in Autism Spectrum Disorder

Samson

Dougherty

Lee

et al. 2016

Psychiatry Research: Neuroimaging

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a b s t r a c tIndividuals with Autism Spectrum Disorder (ASD) have social and communication deficits and difficulties regulating emotions. The brain bases of these socio-affective deficits are not yet clear, but one candidate is structural connectivity in the left uncinate fasciculus, which connects limbic temporal and frontal areas thought to be involved in socio-affective processing. In this study, we assessed white matter structure in the left and right uncinate fasciculus in 18 high-functioning individuals with ASD and 18 group-matched typically developing (TD) controls using Diffusion Tensor Imaging. To test specificity of the associations, we also examined the association between both uncinate fasciculi and restricted and repetitive behaviors. Compared to TD individuals, individuals with ASD had significantly lower fractional anisotropy (FA) in the left and right uncinate. Group status significantly moderated the association between left uncinate and socio-affective deficits, indicating that within the ASD group, FA was associated with socio-affective deficits: Individuals with ASD with lower FA in the left uncinate had significantly more social and emotion regulation deficits. There was no association with restricted and repetitive behaviors. This study provides evidence that the left uncinate may play a critical role in socio-affective skills in individuals with ASD.

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Differences in White Matter Microstructure Among Children With Developmental Coordination Disorder

et al. 2020

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IMPORTANCE Developmental coordination disorder (DCD) is a motor impairment that significantly interferes with activities of daily living. Little is known about the cause of DCD and how it develops, making it difficult to understand why children with DCD struggle in learning motor skills and to determine the best intervention to optimize function.OBJECTIVE To characterize white matter differences using diffusion tensor imaging in children with and without DCD. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study collected diffusion tensorimaging data at BC Children' MAIN OUTCOMES AND MEASURESThe main outcome measures were diffusion parameters, including fractional anisotropy and mean, axial, and radial diffusivity, which are thought to provide an indirect measure of white matter microstructure. Tract-based spatial statistics, a voxelwise statistical analysis of diffusion parameters, were conducted using a 2-group comparison design matrix with age and attention as covariates. RESULTSThirty children without DCD (mean [SD] age, 9.9 [1.4] years; 21 [70%] boys) and 31 children with DCD (mean [SD] age, 10.1 [1.2] years; 26 [84%] boys) were included in the study. Compared with children without DCD, children with DCD were characterized by significantly lower fractional anisotropy and axial diffusivity in regions of white matter pathways associated with motor and sensorimotor processing, including the corticospinal tract (fractional anisotropy: mean [SD], 0.54 [0.03] vs 0.51 [0.03]; P < .001; axial diffusivity: mean [SD], 0.13 [0.98] vs 0.12 [0.46]; P = .01), posterior thalamic radiation at the retrolenticular part of the internal capsule (axial diffusivity: mean [SD], 0.14 [0.57] vs 0.14 [0.44]; P = .01), and cerebellar pathways (eg, superior cerebellar peduncle, fractional anisotropy: mean [SD], 0.49 [0.05] vs 0.46 [0.03]; P = .03; axial diffusivity: mean [SD], 0.14 [0.66] vs 0.14 [0.63]; P = .009). There were no significant differences in mean diffusivity and radial diffusivity between children with and without DCD. CONCLUSIONS AND RELEVANCE These findings suggest that children with DCD show significant brain differences in motor and sensorimotor white matter pathways compared with children without DCD. The pattern of diffusion parameters in children with DCD suggests that axonal development may be disrupted in this neurodevelopmental disorder. Question What white matter microstructural differences are associated with children with developmental coordination disorder (DCD) compared with children without DCD? Findings In this cross-sectional study of 31 children with DCD and 30 children without DCD, widespread differences in indices of white matter microstructure, including fractional anisotropy and axial diffusivity, were observed in children with DCD compared with children without DCD. Meaning These findings suggest that DCD does not simply represent the low end of typical motor skill ability; these children display altered brain development in sensorimotor pathways.Vancouver, British Columbia, Canada; caseload...

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Similar White Matter Aberrations in Children With Autism and Their Unaffected Siblings

Abstract: Our findings suggest that white matter structure may represent a marker of genetic risk for autism or vulnerability to development of this disorder.

Cited by 153 publications

References 98 publications

Structural Neural Phenotype of Autism: Preliminary Evidence from a Diffusion Tensor Imaging Study Using Tract-Based Spatial Statistics

Structural Neural Phenotype of Autism: Preliminary Evidence from a Diffusion Tensor Imaging Study Using Tract-Based Spatial Statistics

White matter structure in the uncinate fasciculus: Implications for socio-affective deficits in Autism Spectrum Disorder

Differences in White Matter Microstructure Among Children With Developmental Coordination Disorder

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