Similarity and difference of pathogenesis among lung cancer subtypes suggested by expression profile data

Dong, Ao; Wang, Ziwen; Ni, N.; Li, Lu; Kong, Xiangyang

doi:10.1016/j.prp.2021.153365

Cited by 5 publications

(2 citation statements)

References 34 publications

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“… 39 Another protector of LUSC prognosis risk, POLR2H , is also associated with unclassified lung cancer survival. 40 These findings partly explain the positive role of gene signatures in LUSC prognosis, which does not contradict their high expression in LUSC samples because our findings also propose a significant negative correlation between their expression and infiltration of major immune cells. Evidence has shown that the malignant phenotype of LUSC is often accompanied by the recruitment of infiltrated immune cells in the tumor immune microenvironment.…”

Section: Discussionsupporting

confidence: 65%

The Evaluation of Prognostic Value and Immune Characteristics of Ferroptosis-Related Genes in Lung Squamous Cell Carcinoma

Su,

Tan,

Gong

et al. 2023

Glob Med Genet

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Background The purpose of our study was to construct a prognostic model based on ferroptosis-related gene signature to improve the prognosis prediction of lung squamous carcinoma (LUSC). Methods The mRNA expression profiles and clinical data of LUSC patients were downloaded. LUSC-related essential differentially expressed genes were integrated for further analysis. Prognostic gene signatures were identified through random forest regression and univariate Cox regression analyses for constructing a prognostic model. Finally, in a preliminary experiment, we used the reverse transcription-quantitative polymerase chain reaction assay to verify the relationship between the expression of three prognostic gene features and ferroptosis. Results Fifty-six ferroptosis-related essential genes were identified by using integrated analysis. Among these, three prognostic gene signatures (HELLS, POLR2H, and POLE2) were identified, which were positively affected by LUSC prognosis but negatively affected by immune cell infiltration. Significant overexpression of immune checkpoint genes occurred in the high-risk group. In preliminary experiments, we confirmed that the occurrence of ferroptosis can reduce three prognostic gene signature expression. Conclusions The three ferroptosis-related genes could predict the LUSC prognostic risk of antitumor immunity.

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Section: Discussionsupporting

confidence: 65%

The Evaluation of Prognostic Value and Immune Characteristics of Ferroptosis-Related Genes in Lung Squamous Cell Carcinoma

Su,

Tan,

Gong

et al. 2023

Glob Med Genet

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“…Several groups have similarly shown how POLR2H is upregulated in prostate cancer and overexpressed in prostate cancer cells compared to the normal tissue, indicating the potential role of POLR2H as a biomarker for prostate cancer prognosis and diagnosis, as well as a potential drug target [123][124][125]. Furthermore, POLR2H mRNA levels are significantly higher in lung cancer tissue samples compared to normal samples [126], and its high expression significantly correlates with patients' survival in lung squamous cell carcinoma [127,128]. Interestingly, more recent data showed that POLR2H is upregulated in a subset of breast cancer patients resistant to radiotherapy, potentially implicating its role in the acquisition of radio-resistance [129,130].…”

Section: Polr2h/rpb8mentioning

confidence: 95%

Deregulations of RNA Pol II Subunits in Cancer

Muste Sadurni,

Saponaro

2023

Applied Biosciences

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Deregulated transcription is a well-known characteristic of cancer cells, with differentially expressed genes being a common feature of several cancers. Often, deregulated transcription is a consequence of alterations in transcription factors (TFs), which play a crucial role in gene expression and can act as tumour suppressors or proto-oncogenes. In eukaryotic organisms, transcription is carried out by three distinct RNA polymerase complexes: Pol I, Pol II, and Pol III. Pol II, specifically, is responsible for transcribing messenger RNA (mRNA), the protein coding part of the genome, as well as long non-coding RNAs (lncRNAs). While there is considerable research on the impact of specific deregulated transcription factors in cancer development, there is a lack of studies focusing on defects within the RNA polymerase complexes and their subunits. This review aims to shed light in particular on the Pol II complex and highlight the deregulation of its subunits that have a significant impact on tumour development, prognosis, and survival. By providing a comprehensive overview of our current understanding of Pol II subunits in cancer, this review emphasizes the importance of further research in this area. It suggests that exploring these subunits’ deregulations could lead to the identification of valuable biomarkers and potential therapeutic targets, making it a topic of collective interest.

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Causal role of immune cells in lung cancer subtypes: Mendelian randomization study

Li,

Xuan,

Wang

et al. 2024

Human Immunology

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Similarity and difference of pathogenesis among lung cancer subtypes suggested by expression profile data

Cited by 5 publications

References 34 publications

The Evaluation of Prognostic Value and Immune Characteristics of Ferroptosis-Related Genes in Lung Squamous Cell Carcinoma

The Evaluation of Prognostic Value and Immune Characteristics of Ferroptosis-Related Genes in Lung Squamous Cell Carcinoma

Deregulations of RNA Pol II Subunits in Cancer

Causal role of immune cells in lung cancer subtypes: Mendelian randomization study

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