Simple and low-cost tabletop NMR system for chemical-shift-resolution spectra measurements

Hibino, Yoshihiko; Sugahara, K.; Muro, Yuji; Tanaka, Hiroshi; Sato, Toshio; Kondo, Yasushi

doi:10.1016/j.jmr.2018.07.003

Cited by 16 publications

(4 citation statements)

References 26 publications

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“…Having determined the characteristics of the constructed gradient coils, and the current requirements to acquire specific spatial resolutions given the overall homogeneity of the magnet, our next step will be to design a custom 3-channel gradient amplifier capable of delivering up to 30 amps for a cost on the order of $1000-2000. The second aim is to design a new console based on low-cost hardware such as software defined radios (SDR) or similar architecture [39][40][41][42][43] and open source software. Essentially such a system would simply be required to send out a series of pulses (RF pulses, gradient pulses, TTL pulses for amplifier blanking/ unblanking) and time-synchronized data acquisition.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

O’Reilly

Teeuwisse

Webb

2019

Journal of Magnetic Resonance

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Section: Discussionmentioning

confidence: 99%

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

O’Reilly

Teeuwisse

Webb

2019

Journal of Magnetic Resonance

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“…The cost of modern equipment used for identification also tends to decrease with the development and research of new machines with low-cost materials, such as low-resolution NMR (Hibino et al 2018). UPLC-MS equipment decreases the cost of analysis by consuming less time of equipment usage, and therefore reducing solvent consumption, besides having the advantage of an increase in resolution (Kumar et al 2012; Nováková et al 2006).…”

Section: Resultsmentioning

confidence: 99%

A chemistry overview of the beautiful miniature forest known as mosses

2023

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The bryophytes are the second largest group of land plants and are represented by three lineages: Marchantyophyta (liverworts), Anthocerotophyta (hornworts), and Bryophyta (mosses). They occupy a wide variety of habitats, from deserts to Antarctica, and exercise great ecological importance. These facts and their wide use in traditional medicine raise the question of what is known about moss chemistry. This paper gathered studies from the last 52 years about the compounds identified in mosses, aiming to address the following questions: Are mosses chemically under-studied? How many families, genera, and species of mosses have been chemically studied? Which continent and countries have been responsible for the majority of these studies? A literature search was performed in major scientific databases, using a combination of keywords. A total of 199 papers were compiled, of which 45% were published during the last decade. Only a small percentage of moss species has been studied, mostly from Europe and Asia. Dicranales and Hypnales are the most studied orders. In general, fatty acids and flavonoids are the most commonly reported classes of compounds. Biflavonoids and triflavonoids are detected mainly in derived clades of mosses, while coumarins are most reported for basal groups. Akthough only a small percentage of moss species has been chemically studied, most of these studies were published in the last decade—there has been a 135% increase in the number of reported compounds in the last 13 years. The emergence of new equipment, which can produce high-resolution spectra with small amounts of sample, combined with bioinformatics tools, has undoubtedly contributed to the increase of chemical investigation of mosses. Also, advances in the identification and phylogenetics of moss groups are contributing to a better understanding of them generally, which should lead also to increased study of moss chemistry.

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“…Recent studies have demonstrated spectral resolution without the need for added shim coils [8], as well as examples that implement a practicable shim stack [15]. More broadly, recent advances have been made toward making the NMR spectrometer simple, portable, and more closely based on off-the-shelf test and measurement equipment [16,17]. Importantly, thus far, all such advances detail an engineering of the spectrometer device itself, rather than addressing a strategy to provide a finer level of control, applicable to all instruments, when visualizing and processing the data.…”

Section: Introductionmentioning

confidence: 99%

A Modernized View of Coherence Pathways Applied to Magnetic Resonance Experiments in Unstable, Inhomogeneous Fields

Beaton,

Guinness,

Franck

2022

Preprint

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Over recent decades, motivated either by practicality or the need to tap into new types of measurements, the science of Magnetic Resonance has expanded into more adverse conditions: deliberately chosen lower frequencies, inhomogeneous fields, and/or time-variable fields. The extensive body of research involving NMR at higher and more homogeneous fields -i.e., highly optimized static magnetic fields, encourages the assumption that previous research has precluded the discovery of new techniques and perspectives relevant to the acquisition of one dimensional NMR data. However, Overhauser Dynamic Nuclear Polarization (ODNP) presents a case study that challenges this expectation and offers an interesting test-bed for further developments. For example, an interest in the nanoscale heterogeneities of hydration dynamics demand increasingly sophisticated and automated measurements deploying ODNP on a modular, open source instrument operating at 15 MHz. As part of this effort, ODNP requires the acquisition and automated processing of large quantities of one dimensional NMR spectra. The acquisition of this data can present various problems: in particular, unambiguous identification of signal in newly configured instruments presents a practical challenge, while field drift tends to remain an issue even in fully configured instruments, among other issues.Recent advances in the capabilities of open-source libraries opened up the opportunity to address these issues at the fundamental level, by developing a specific schema that treats the phase cycle of a pulse as an explicit "phase domain" dimension that Fourier transforms into the "coherence domain." In particular, a standardized protocol for organizing and visualizing the resulting data clearly presents all the information available from all coherence transfer pathways of a phase-cycled experiment, with intelligible results that don't rely on preliminary phase corrections. It thus organizes and visualizes data in ways that more accurately reflect the rich physics of the underlying NMR experiments, and that more fully bear out the original fundamental concepts of coherence transfer pathways. It also enables development of a collection of algorithms that provide robust phasing, avoidance of baseline distortion, and the ability to lift relatively weak signals out of a noisy background through a signal-averaged mean-field correlation alignment algorithm. Both the schema for processing and visualizing the raw data, and the algorithms whose developments it guides are expected to be either directly applicable or easily extensible to other techniques facing similar challenges, particularly to other emerging forms of coherent spectroscopy that support pulse phase cycling.

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Simple and low-cost tabletop NMR system for chemical-shift-resolution spectra measurements

Cited by 16 publications

References 26 publications

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

A chemistry overview of the beautiful miniature forest known as mosses

A Modernized View of Coherence Pathways Applied to Magnetic Resonance Experiments in Unstable, Inhomogeneous Fields

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Simple and low-cost tabletop NMR system for chemical-shift-resolution spectra measurements

Cited by 16 publications

References 26 publications

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

A chemistry overview of the beautiful miniature forest known as mosses

A Modernized View of Coherence Pathways Applied to Magnetic Resonance Experiments in Unstable, Inhomogeneous Fields

Contact Info

Product

Resources

About

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet

Three-dimensional MRI in a homogenous 27 cm diameter bore Halbach array magnet