Simple and rapid electrochemical detection of 1-benzylpiperazine on carbon screen-printed electrode

Rocha, Raquel G.; Silva, Isabella C.O.F.; Arantes, Luciano José; Stefano, Jéssica S.; Lima, Camila D.; Melo, Larissa M.A.; Muñoz, Rodrigo A.A.; Santos, Wallans Torres Pio dos; Richter, Eduardo M.

doi:10.1016/j.microc.2021.106282

Cited by 20 publications

(6 citation statements)

References 40 publications

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“…Es bien conocido el buen desempeño analítico que presentan las técnicas de separación con espectrometría de masas. Las altas sensibilidad y selectividad hacen posible la determinación, básicamente, de cualquier psicotrópico y de sus derivados con un elevado porcentaje de confiabilidad, incluso a niveles de concentración muy SWV BDD BA pH 4,0 0,04 08-2017 [114] SWV BDD BA pH 9,5 0,04 04-2018 [115] DPV BDD CH 3 CN/TEAP 0,24 01-2021 [116] DPV SP-C BBR pH 8,0 0,44 01-2021 [116] DPV SP-Pt CH 3 CN/TEAP 0,76 01-2021 [116] BZP SWV CP BBR pH 9,5 1,0 12-2016 [117] DPV BDD CH 3 CN/TEAP 0,77 01-2021 [116] DPV SP-C BBR pH 9,0 0,61 01-2021 [116] DPV SP-Pt CH 3 CN/TEAP 1,3 01-2021 [116] DPV SP-C BBR pH 5,0 0,05 04-2021 [118] mCPP POT PMBS Tris-HCl pH 7,0 0,10 09-2019 [119] DPV BDD BBR pH 10 0,22 02-2020 [120] DPV BDD CH 3 CN/TEAP 0,27 01-2021 [116] DPV SP-C BBR pH 8,0 0,15 01-2021 [116] DPV SP-Pt CH 3 CN/TEAP 1,1 01-2021 [116] SWV SP-C BBR pH 7,0 0,02…”

Section: Sensores Electroquímicos Para El Análisis De Drogas Emergent...unclassified

Drogas emergentes: detección mediante sensores electroquímicos

González-Hernández

2024

Rev. Colomb. Quim.

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La cantidad de nuevas sustancias psicoactivas, popularmente conocidas como drogas emergentes, sintéticas o recreativas, aumenta en el mercado global cada año. El uso de nuevas tecnologías para la producción y comercialización de las sustancias, aunado a una demanda exigente de nuevos efectos psicotrópicos más potentes, son algunos de los factores que contribuyen al incremento de una oferta más variada, así como a la cantidad de consumidores de algún tipo de psicoestimulante. El desarrollo de herramientas analíticas fiables con capacidad de respuesta in situ para una evaluación preliminar, contribuyen significativamente con la generación de información científica para atender casos de intoxicaciones, aplicar correctamente la legislación e inclusive aportar datos reales para una reclasificación más justa de las drogas basada en criterios objetivos. Los sensores electroquímicos han ganado terreno en áreas como la toxicología y las ciencias forenses. Esencialmente, porque son dispositivos portátiles de fácil manipulación, altamente versátiles, con mínimos requerimientos en el tratamiento de la matriz y que necesitan cantidades muy pequeñas de muestra. Asimismo, las metodologías electroquímicas presentan excelentes parámetros de desempeño como bajos límites de detección, alta sensibilidad y muy buena precisión. Esta revisión se enfoca en la aplicación de sensores electroquímicos voltamperométricos para el análisis de drogas.

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Section: Sensores Electroquímicos Para El Análisis De Drogas Emergent...unclassified

Drogas emergentes: detección mediante sensores electroquímicos

González-Hernández

2024

Rev. Colomb. Quim.

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“…2021 electrochemical method for BZP determination in beverage (vodka, whisky and white wine) and seized street samples using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) [ 16 ].…”

Section: Routine and Improved Analyses Of Abused Substancesmentioning

confidence: 99%

Interpol Review of Drug Analysis 2019-2022

Love

Jones

2023

Forensic Science International: Synergy

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“…A laboratory-based analyses of 1 could easily be conducted by using spectroscopic and chromatographic techniques [ 12 , 13 ], but reports on potential on-site detection have been limited to electrochemical methods [ 14 , 15 ] and presumptive colour tests [ 12 , 16 ]. While presumptive colour tests are rapid and cheap, these are prone to false positives, some tests are pH dependent and reagents have limited stability even with low temperature storage.…”

Section: Introductionmentioning

confidence: 99%

Molecular Imprinting of Benzylpiperazine: A Comparison of the Self-Assembly and Semi-Covalent Approaches

Wright

Bowyer

McCluskey

et al. 2023

IJMS

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Molecularly imprinted polymers (MIPs) for benzylpiperazine (BZP, 1), an illicit designer drug, were developed by using both self-assembly and semi-covalent approaches. From an array of potential functional monomers (FMs) and using a combination of pre-synthetic interaction studies (by molecular modelling and NMR analysis) and binding assays, the highest performing self-assembly 1-MIPs were confirmed to result from methacrylic acid (7) as FM, ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) as crosslinkers and chloroform as the porogen and rebinding solvent at template (T): FM ratios of 1:1 and 1:2, giving imprinting factors (IF) 3 to 7. The semi-covalent 1-MIPs were designed using benzylpiperazine (4-vinylphenyl) carbamate (16) as the template–monomer adduct in combination with either EDGMA or TRIM. Our comparative analysis showed the semi-covalent polymers to have a stronger affinity for 1 (significantly lower Kd values and higher IFs) and faster uptake than the self-assembly systems. Both approaches have comparable cross-reactivity: marginal to low against cocaine (17) and morphine (18) and high against ephedrine (19) and phenylpiperazine (20). They also have comparable selectivity: highly selective towards 1 against 17, moderate against 18 and non-selective against 19. EGDMA-based self-assembly MIPs displayed a greater imprinting effect (higher IFs and NIP-to-MIP Kd ratios) than TRIM-based MIPs, while the TRIM-based semi-covalent MIP outperformed its EGDMA-based equivalent. By virtue of its modest selectivity against the test illicit drugs, 1-MIPs could potentially be used as a dummy MIP for the broad-based capture and enrichment of illicit drug blends for subsequent laboratory analysis.

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Simple and rapid electrochemical detection of 1-benzylpiperazine on carbon screen-printed electrode

Cited by 20 publications

References 40 publications

Drogas emergentes: detección mediante sensores electroquímicos

Drogas emergentes: detección mediante sensores electroquímicos

Interpol Review of Drug Analysis 2019-2022

Molecular Imprinting of Benzylpiperazine: A Comparison of the Self-Assembly and Semi-Covalent Approaches

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