Simple Anthropometric Indices are Useful for Predicting Non-alcoholic Fatty Liver Disease [NAFLD] in Asian Indians

Singh, Ayaskanta; Parida, Sasmita; Narayan, Jimmy; Nath, Preetam; Padhi, Pradeep Kumar; Pati, Girish Kumar; Parida, Pramod Kumar; Meher, Chudamani; Agrawal, Omprakash; Singh, Shivaram Prasad

doi:10.1016/j.jceh.2017.05.005

Cited by 19 publications

(15 citation statements)

References 25 publications

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“…Generally, BMI<25 and BMI≥25 indicate normal body weight and obesity, respectively [ 22 ]. Abdominal obesity was considered as WC≥102 cm and WHR≥0.9 in men and WC≥88 cm and WHR≥0.85 in women (WHR = WC/HC) [ 19 ]. A WHtR of ≥0.5 (WHtR = WC/height) permits identifying obesity.. WHtR≥0.5 indicates an increased risk of obesity-related diseases in both genders in all races [ 19 ].…”

Section: Study Measurementmentioning

confidence: 99%

“…Abdominal obesity was considered as WC≥102 cm and WHR≥0.9 in men and WC≥88 cm and WHR≥0.85 in women (WHR = WC/HC) [ 19 ]. A WHtR of ≥0.5 (WHtR = WC/height) permits identifying obesity.. WHtR≥0.5 indicates an increased risk of obesity-related diseases in both genders in all races [ 19 ]. The WC and WHR were measured using a tape measure with a precision of 0.1 cm at the midpoint of the lower limit of the last rib and above the lower part of the iliac crest in the maximal hip circumference position, respectively.…”

Section: Study Measurementmentioning

confidence: 99%

“…However, WC does have limits, e.g., the amount of the abdominal fat is estimated to be lower in short people compared to the tall ones [ 15 , 18 ]. WC, WHR and WHtR have been considered as alternative indices for abdominal obesity in previous studies [ 19 ]. Since NAFLD can lead to the development of liver diseases and impose huge costs, it is very important to identify people at risk.…”

Section: Introductionmentioning

confidence: 99%

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The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Mansour-Ghanaei

Naghipour

et al. 2018

JMedLife

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Introduction: Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated health problem that causes other liver diseases for the patient. Four anthropometric indices: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were analyzed as NAFLD predictors in the present study.Methods: From the total number of individuals who referred to the PERSIAN Guilan Cohort study (PGCS) located in the north of Iran during the period of study, a total of 960 people were enrolled in the present study. NAFLD was diagnosed using through an abdominal ultrasound exam. Height, weight, WC, BMI, WHR and WHtR were later calculated. Chi-square, ANOVA and logistic regression analyses were used to analyze the risk factors.Results: Out of the 960 individuals who were enrolled in the study, 597 (62.2%) were male and 363 (37.8%) were female (with an average age of 47.21 ± 7.29 years). There was a significant relationship between weight and NAFLD (P<0.001). There was also a significant relationship between BMI (OR= 8.41; 95% CI = 5.59–12.75), WC (OR= 2.67; 95% CI = 2.05–3.48), WHR (OR= 3.84; 95% CI = 2.26–6.52), WHtR (OR= 28.53; 95% CI = 6.94–117.31) and NAFLD (P<0.001). The results of the logistic regression analysis showed that WHtR, BMI and WC were effective predictors for the risk of NAFLD while WHtR played a more important role in the prediction of NAFLD.Conclusion: Anthropometric indices, especially WHtR, as a simple screening tool, seem to be an important criterion for the detection of NAFLD.

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Section: Study Measurementmentioning

confidence: 99%

Section: Study Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Mansour-Ghanaei

Naghipour

et al. 2018

JMedLife

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“…A recent study has demonstrated that the appropriate cutoffs for BMI in screening for NAFLD were 24 in Chinese [ 30 ], 24.4 in Asian Indian [ 36 ], and 23.2 in Iranian [ 37 ] patients. BMI = 25 was defined as a cutoff for obesity among people in the Asia-Oceania region [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Elevated Liver Enzymes in Japanese Women With Polycystic Ovary Syndrome

et al. 2018

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BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS is associated with an increased risk of obesity and insulin resistance, little is known regarding the prevalence of and risk factors for nonalcoholic fatty liver disease (NAFLD) among Japanese women with PCOS. We estimated the prevalence of and risk factors for elevated liver enzymes, as the index of NAFLD, in Japanese women with PCOS.MethodsWe retrospectively reviewed 102 reproductive-aged women who visited the Department of Gynecology, Kyoto Medical Center in Japan from January 2000 to September 2016. Inclusion criterion was confirmed diagnosis of PCOS using International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10) codes. Exclusion criteria were women with a history of liver diseases, missing body mass index (BMI) and serum alanine aminotransferase (ALT) data, and pregnancy. Data regarding age; BMI; and levels of blood glucose, serum lipid, liver enzymes, and sex hormones were obtained from medical records. Elevated liver enzymes was defined as ALT > 19 IU/L. Optimal cutoffs for risk factors for elevated liver enzymes were calculated to determine predictors of elevated liver enzymes using area under the curve (AUC) by receiver-operating characteristics (ROC).ResultsThe prevalence of elevated liver enzymes was 33.3%. BMI was significantly higher in PCOS patients than in those without elevated liver enzymes (25.3 vs. 20.7 kg/m2, P < 0.05). ROC analyses were performed using BMI and blood glucose and testosterone levels because BMI and blood glucose showed differences between the groups and testosterone is related to fatty liver. AUC of the model including BMI and blood glucose and testosterone levels was 0.861 (sensitivity, 66.7%; specificity, 100%).ConclusionsThese findings suggest that elevated liver enzymes are common in women with PCOS. An algorism using BMI and blood glucose and testosterone levels might be useful to determine elevated liver enzymes in women with PCOS. Our finding may be useful for the study of NAFLD among Japanese women with PCOS since several previous studies have indicated elevated liver enzymes to be related to the potential presence of NAFLD. Further examination, including abdominal ultrasonography and/or liver biopsy data, is required to confirm these results.

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“…The study protocol had gained approval from The Ethics Committee of Widya Mandala Catholic University Surabaya Faculty of Medicine. The ideal waist-to-hip ratio is < 0.9 for males and < 0.85 for females.The high ratio is  0.9 for males and  0.85 for females(17).…”

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confidence: 93%

The Association Between Risk Factors And Ultrasound-Based Grades Of Non-Alcoholic Fatty Liver Disease In Type-2 Diabetes Patients

Jong

Mellow

2019

J.Widya Medika

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Background: Non-alcoholic fatty liver disease (NAFLD) has become more common as the cause of cirrhosis and liver cancer. The liver disease is highly prevalent in people with type-2 diabetes. Indonesia is not spared from the global epidemic of type-2 diabetes. The ultrasound examination is clinically easy-to-use, economical and non-invasive as a tool to detect NAFLD, compared to the gold standard, liver biopsy. To date, there has been no study in Indonesia to link risk factors and ultrasound-based severity grading of NAFLD. Aim: To understand the association between risk factors and ultrasound-based grades of NAFLD in patients with type-2 diabetes. Method: The present study was an observational study with a cross-sectional design (May-October 2018) that involved 82 type-2 diabetes outpatients of the internal medicine clinic in the Gotong Royong Hospital (Surabaya, Indonesia). The risk factors assessed were gender, age, diabetes duration, obesity (anthropometric measurement: body mass index/ BMI, waist circumference and waist-to-hip ratio), glycemic control (hemoglobin A1c/ HbA1c level) and dyslipidemia (lipid profile: total cholesterol, low-density lipoprotein/ LDL, high-density lipoprotein/ HDL and triglyceride). The ultrasound-based grades of NAFLD consisted of grade 0 (no NAFLD), grade 1 (increased liver echogenicity with normal images of intrahepatic vessel lines and diaphragm), grade 2 (blurred image of intrahepatic vessel lines) and grade 3 (blurred images of intrahepatic vessel lines and diaphragm). Statistical p-value was significant at ≤ 0.05. Results: Seventy-eight subjects (95,1%) had NAFLD. The ultrasound-based NAFLD grades were significantly different across age groups (Kruskal-Wallis) but the Spearman’s rank correlation test result was not significant. Body mass index and total cholesterol were positively correlated (r = 0.390 and 0.237, respectively) with the NAFLD grades. Conclusion: Higher BMI and total cholesterol are associated with increased ultrasound-based NAFLD grades.

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Simple Anthropometric Indices are Useful for Predicting Non-alcoholic Fatty Liver Disease [NAFLD] in Asian Indians

Cited by 19 publications

References 25 publications

The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)

Prevalence and Risk Factors of Elevated Liver Enzymes in Japanese Women With Polycystic Ovary Syndrome

The Association Between Risk Factors And Ultrasound-Based Grades Of Non-Alcoholic Fatty Liver Disease In Type-2 Diabetes Patients

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