Simple coupled ultrahigh performance liquid chromatography and ion chromatography technique for simultaneous determination of folic acid and inorganic anions in folic acid tablets

Wang, Fenglian; Cao, Meng; Wang, Nani; Nadeem, Muhammad; Wu, Shuchao; Zhu, Yan

doi:10.1016/j.foodchem.2017.06.016

Cited by 34 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different methods have been reported in the literature for the quantification of FA, including spectrophotometric methods [9,10], electrochemical techniques [11,12], high-performance liquid chromatography (HPLC) [13,14,15] and ultrahigh HPLC, and ion chromatography [16]. In general, these methods are based on time-consuming reactions that involve laborious and slow procedures.…”

Section: Introductionmentioning

confidence: 99%

CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid

Ramírez‐Herrera

Reyes-Cruzaley

Dominguez

et al. 2019

Sensors

View full text Add to dashboard Cite

In this paper, we report the synthesis, characterization, and application of a new fluorescent nanosensor based on water-soluble CdTe quantum dots (QDs) coated with cysteamine (CA) for the determination of folic acid (FA). CdTe/CA QDs were characterized by high-resolution transmission electron microscopy, the zeta potential, and Fourier-transform infrared (FT-IR), UV-visible, and fluorescence spectroscopy. CdTe QDs coated with mercaptopropionic acid (MPA) and glutathione (GSH) were prepared for comparison purposes. The effect of FA on the photoluminescence intensity of the three thiol-capped QDs at pH 8 was studied. Only CdTe/CA QDs showed a notable fluorescence quenching in the presence of FA. Then, a nanosensor based on the fluorescence quenching of the CdTe QDs at pH 8 was explored. Under optimum conditions, the calibration curve showed a linear fluorescence quenching response in a concentration range of FA from 0.16 to 16.4 μM (R2 = 0.9944), with a detection limit of 0.048 μM. A probable mechanism of fluorescence quenching was proposed. The nanosensor showed good selectivity over other possible interferences. This method has been applied for FA quantification in orange beverage samples with excellent results (recoveries from 98.3 to 103.9%). The good selectivity, sensitivity, low cost, and rapidity make CdTe /CA QDs a suitable nanosensor for FA determination.

show abstract

Section: Introductionmentioning

confidence: 99%

CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid

Ramírez‐Herrera

Reyes-Cruzaley

Dominguez

et al. 2019

Sensors

View full text Add to dashboard Cite

show abstract

“…Various expensive instruments have been applied for the analytical determination of NTP and other NNIs such as GC‐MS , liquid chromatography coupled with mass spectrometry , tandem mass spectrometry and diode‐array detection . However, the need of complex derivatization for their GC‐MS analysis, expensive LC‐MS/GC‐MS instrumentation and a complicated sample pretreatment make their use limited to developing countries laboratories .…”

Section: Introductionmentioning

confidence: 99%

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

Nadeem

Zhang

et al. 2018

J of Separation Science

Self Cite

View full text Add to dashboard Cite

A simple, cost-effective, sensitive, and quick method for the determination of nitenpyram and its metabolite 6-chloronicotinic acid in environmental samples was developed by coupling an ion chromatograph with a fluorescence detector and a post-column photochemical reactor. This developed analytical method involved a rapid sample extraction by modified and miniaturized quick, easy, cheap, effective, rugged, and safe method followed by isocratic ion chromatographic separation of nitenpyram and 6-chloronicotinic acid into an IonPac AS11-HC column protected by IonPac AG11A guard column by running 30 mM NaOH + 10% acetonitrile mobile phase. A homemade post-column photochemical reactor was also integrated with the ion chromatographic system for online transformation of both analytes into their respective highly fluorescent photoproduct in basic media without using an extra pump. The developed method was validated by following SANTE/11945/2015 guidelines on analytical quality control and validation procedures. The method showed a good linear response (r > 0.999), improved limit of detection (0.101-0.132 μg/L), minimum or no matrix effect, excellent recoveries (90.2-100.10%) and relative standard deviations were found to be ≤6.50%.

show abstract

“…So far, various methods have been proposed for quantitative detection of folic acid, such as microbiological assay, [ 8 ] surface‐enhanced Raman scattering, [ 9 ] high‐performance liquid chromatography (HPLC), [ 10 ] electrochemical assays, [ 11 ] and so on. However, there are still many disadvantages, such as time‐consuming, expensive equipment, complicated pretreatment, and so on, which limit their applications.…”

Section: Introductionmentioning

confidence: 99%

Glycidol‐modified polyethylenimine‐capped carbon dots with ultrastable fluorescence for sensitive and selective detection of folic acid in food samples

Zhan

Wang

2022

J Chinese Chemical Soc

View full text Add to dashboard Cite

Glycidol‐modified polyethylenimine (PEI‐OH)‐capped carbon dots (PEI‐OH‐CDs) were prepared and applied for selectively and sensitively detecting folic acid in food samples. PEI‐OH‐CDs were firstly synthesized by a one‐pot hydrothermal method using PEI‐OH and citric acid as precursors, and the transmission electron microscopy characterization reveals that the PEI‐OH‐CDs were of spherical shape with diameters of 2–3 nm and well dispersed in solution. The PEI‐OH‐CDs have high fluorescence and exhibit ultrastrong stability against pH, ion strength, and UV light irradiation. In a wide pH range higher than pH 6, the fluorescence of PEI‐OH‐CDs can be effectively quenched by folic acid through static quenching process and inner filter effect but is not affected by many typical chemicals including cations, anions, amino acids, and vitamins. A good linear relationship was found between the F0/F and the concentration of folic acid in the range from 0.1 to 100 μM, and the detection limit of folic acid is 0.07 μM. The PEI‐OH‐CDs were successfully applied for sensitive determination of folic acid in orange juice, fresh pear, grape spinach, and celery samples at pH 7.2, which is helpful to the stability of folic acid and provides a new strategy for accuracy detection of folic acid in food samples.

show abstract

Simple coupled ultrahigh performance liquid chromatography and ion chromatography technique for simultaneous determination of folic acid and inorganic anions in folic acid tablets

Cited by 34 publications

References 14 publications

CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid

CdTe Quantum Dots Modified with Cysteamine: A New Efficient Nanosensor for the Determination of Folic Acid

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

Glycidol‐modified polyethylenimine‐capped carbon dots with ultrastable fluorescence for sensitive and selective detection of folic acid in food samples

Contact Info

Product

Resources

About