Simple, fast, and low-cost synthesis of MIL-100 and MIL-88B in a modified domestic microwave oven

Aguiar, Laís Weber; Otto, Guilherme Piovezan; Kupfer, Vicente L.; Fávaro, Sílvia Luciana; Silva, Cleiser Thiago P.; Moisés, Murilo Pereira; Almeida, Leandro de; Guilherme, Marcos R.; Radovanovic, Eduardo; Girotto, Emerson M.; Rinaldi, Andrelson W.

doi:10.1016/j.matlet.2020.128127

Cited by 19 publications

(6 citation statements)

References 28 publications

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“…The P-XRD patterns of 2-PAM@MIL-88B(Fe), MIL-88B(Fe), and 2-PAM@MIL-88B(Fe) after drug release were obtained. As shown in Figure , the P-XRD peaks of the as-prepared MIL-88B(Fe) at 2θ = 9.1, 11.3, 18.5, and 19.6° were highly consistent with those in the simulated spectrum of MIL-88B(Fe), ,, indicating that the as-prepared MIL-88B(Fe) was pure. For 2-PAM@MIL-88B(Fe), P-XRD diffraction peaks appeared at 2θ = 9.1, 11.3, 18.5, and 19.6°, which were attributed to MIL-88B(Fe).…”

Section: Resultssupporting

confidence: 56%

“…The IR spectrum of MIL-88B(Fe) was consistent with previous studies. , Specifically, the broad absorption band near 3200 cm –1 corresponds to the stretching vibration of the O–H bond in H 2 O, while the bands at 1573 and 1382 cm –1 correspond to symmetrical and antisymmetric stretching vibrations of −COO– in terephthalic acid, respectively. The bands at 810 and 745 cm –1 correspond to the bending vibration of the benzene ring . In the IR spectrum of 2-PAM, the bands at 3030, 1480, and 1180 cm –1 correspond to the stretching vibrations of the C–H bond, the stretching vibrations of the CN bond, and the bending vibrations of the C–H bonds on the pyridine ring, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents

et al. 2021

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Maintaining a long-term continuous and stable reactivator blood concentration to treat organophosphorus nerve agent poisoning using acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) is very important yet difficult. Because the flexible framework of MIL-88B(Fe) nanoparticles (NPs) can swell in polar solvents, pralidoxime chloride (2-PAM) was loaded in MIL-88B(Fe) NPs (size: ca. 500 nm) by stirring and incubation in deionized water to obtain 2-PAM@MIL-88B(Fe), which had a maximum drug loading capacity of 12.6 wt %. The asprepared composite was characterized by IR, powder X-ray diffraction (P-XRD), scanning electron microscopy (SEM), ζpotential, Brunauer−Emmett−Teller (BET), and thermogravimetry/differential thermal analysis (TG/DTA). The results showed that under constant conditions, the maximum drug release rates of 2-PAM@MIL-88B(Fe) in absolute ethanol, phosphate-buffered saline (PBS) solution (pH = 7.4), and PBS solution (pH = 4) at 150 h were 51.7, 80.6, and 67.1%, respectively. This was because the composite showed different swelling behaviors in different solvents.

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Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents

et al. 2021

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“…By optimizing the reaction temperature, time, and solvent ratios, both micro- and nanometer-sized crystals were prepared. In addition, it was found to be a method of choice for fast crystallization of HKUST-1 145 , MIL-53 (Fe) 73 , MIL-101-NH2 (Fe) 136 , ZIF-8 146 and MIL-100 147 .…”

Section: Synthesis Of Mofsmentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.

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“… 17 ) and MIL-100 (ref. 18 ) samples prepared at room temperature, as shown in Table 1 . When MIL-100 was added to the ZIF-MIL series, the specific surface area of the samples was decrease compared to ZIF-8, but in ZIF-MIL-4, the specific surface area was slightly higher than that of MIL-100.…”

Section: Resultsmentioning

confidence: 99%

High-performance and selective adsorption of ZIF-8/MIL-100 hybrids towards organic pollutants

Zhong

Cheang

2022

Nanoscale Adv.

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Simple, fast, and low-cost synthesis of MIL-100 and MIL-88B in a modified domestic microwave oven

Cited by 19 publications

References 28 publications

Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents

Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents

Metal-organic frameworks for advanced drug delivery

High-performance and selective adsorption of ZIF-8/MIL-100 hybrids towards organic pollutants

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