Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

Abstract

Nail lacquers represent new drug form specifically designed to treat infected nail plate. They are complex organic solutions with specific assaying problems due to the high content of the polymer and plasticizer. Furthermore, there is a lack of assaying methods of active substances from this type of formulations in scientific literature. We developed derivative UV-spectrophotometric method for determination of fluconazole content in antifungal nail lacquer formulations. The method was validated for specificity, linearity, precision (repeatability), intermediate precision and accuracy (recovery). The method is specific, linear in the range of 99.53 -497.65 μg/ml, precise and showed good recovery (98.79% -101.77% from all six developed formulations). Besides, it is inexpensive, simple and nontoxic, i.e. ecologically acceptable. This method can be used for assaying fluconazole from this type of formulations.

Therapeutic nail polishes based on ciclopirox

“…Recent advances in drug delivery technology have led to the introduction of drugcontaining varnishes [15,16], which, when applied to the nail, form a film on it after evaporation of the solvent, from which the drug is released in a sustained manner and reaches the target site -the nail matrix and nail bed. Nail polish with a therapeutic substance mainly contains an active ingredient, a film-forming polymer, a plasticizer and a volatile organic solvent [17]. The advantage of nail polish is the long contact time of the drug with the nail, so that the effective concentration can be reached at the desired site.…”

Comparative study of normal, micro- & nano-sized iron oxide effect in potentiometric determination of fluconazole in biological fluids

“…4 However, some of these methods need expensive equipment and/ or are time-consuming. Moreover, several spectroscopic methods have been developed for the determination of FLU, [5][6][7][8][9] but they need pretreatment steps before application in biological uids.…”