Simple, rapid, and sensitive liquid chromatography-fluorescence method for the quantification of tranexamic acid in blood

Huertas-Pérez, José F.; Heger, Michal; Dekker, Henk; Krabbe, Hans; Lankelma, J.; Ariese, Freek

doi:10.1016/j.chroma.2007.04.067

Cited by 36 publications

(35 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These low recovery levels may be caused by coprecipitation of these metabolites together with proteins during the centrifugation step of the acid extraction preparation of the samples or with the perchlorate precipitate after neutralization [25,26]. In whole blood, precipitate volumes are large, and the 20% adjustment of concentration to correct for this volume change may have been an overcorrection for more apolar metabolites, such as uric acid, adenine and hypoxanthine, resulting in lower recoveries.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection

Coolen

Arts

Swennen

et al. 2008

Journal of Chromatography B

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection

Coolen

Arts

Swennen

et al. 2008

Journal of Chromatography B

View full text Add to dashboard Cite

“…Compared with the products formed by derivatization with OPA, the NDA/CN derivatives exhibit improved chemical stability, excitation maxima (420 and 440 nm) in the visible region, efficient chemiluminescence by the peroxyoxalate method and enhanced fluorescence quantum efficiency [41]. NDA has been used for the derivatization of amino acids and peptides [41][42][43][44][45], catecholamines [46][47][48][49], aliphatic amines [50], heterocyclic amines [51,52], aliphatic diamines [53], drugs [54][55][56] and lipids [57]. The main features of these methods are summarized in Electronic supplementary material (ESM) Table S1.…”

Section: Introductionmentioning

confidence: 99%

Study of the naphthalene-2,3-dicarboxaldehyde pre-column derivatization of biogenic mono- and diamines in mixture and fluorescence−HPLC determination

Zotou

Notou

2011

Anal Bioanal Chem

View full text Add to dashboard Cite

A new fluorescence-HPLC method was developed for the simultaneous determination of eight biogenic monoamines (histamine, methylamine, tyramine, ethylamine, propylamine, tryptamine, 2-phenylethylamine, isoamylamine) and two biogenic diamines (putrescine, cadaverine) in the presence of heptylamine as the internal standard. The amines were pre-column derivatized with naphthalene-2,3-dicarboxaldehyde in the presence of cyanide ion as the nucleophile. The effect of the derivatization reaction conditions on the reaction yield was investigated. The derivatives were separated on an Inertsil ODS-3 column (250 × 4mm i.d., 5 μm) using gradient elution and detected fluorimetrically at excitation and emission wavelengths of 424 and 494 nm, respectively. Limits of detection between 0.002 and 0.4 ng, injected on-column (10-μL loop), were achieved. The within- and between-day relative standard deviations ranged between 0.2-3.4% and 0.3-4.8%, respectively. The utility of the method in assaying biogenic mono- and diamine mixtures in Greek cheeses is demonstrated. Ultrasound-assisted liquid-liquid extraction was applied prior to derivatization.

show abstract

“…In the present study, there were improvements not only in surface spot, wrinkles, texture and pores facial skin status, but also in self-perceived pigmented spots, rough complexion, red complexion, wrinkle and obvious pores facial skin problems after using whitening cosmetic products. It has recently been proposed that tranexamic acid is not only a synthetic antifibrinolytic agent but also a whitening ingredient in cosmetics [10] [20]. In addition, antioxidants are becoming increasingly important in whitening cosmetics according to their anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

Objective and Self-Perceived Facial Skin Status Using Whitening Efficacy of Cosmetic Products on Taiwanese Women

Lin¹,

Chen²,

Yen³

et al. 2016

JCDSA

View full text Add to dashboard Cite

Background: Tranexamic acid and vitamin C derivatives are important reagent used in cosmetic skin-whitening products. Recently, self-perceptions regarding improvement in facial skin status have been increasingly recognized as an important outcome of whitening cosmetic products intervention. Aims: The purpose of the study was to determine the receptiveness of objective and self-perceived facial skin status using whitening cosmetic products. Methods: A total of 40 volunteers were photographed using the Visia ® machine and completed questionnaires at pre-and post-operation (8 weeks after receiving whitening cosmetic products). Visia ® digital image analysis and questionnaires were used for assessment of facial skin status. The receptiveness of objective and self-perceived measures was assessed by paired t test and Effect Size (ES) .

show abstract

Simple, rapid, and sensitive liquid chromatography-fluorescence method for the quantification of tranexamic acid in blood

Cited by 36 publications

References 46 publications

Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection

Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection

Study of the naphthalene-2,3-dicarboxaldehyde pre-column derivatization of biogenic mono- and diamines in mixture and fluorescence−HPLC determination

Objective and Self-Perceived Facial Skin Status Using Whitening Efficacy of Cosmetic Products on Taiwanese Women

Contact Info

Product

Resources

About